New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities
Abstract
The phytochemical investigation of a Tunisian plant Atriplex portulacoides (Chenopodiaceae) led to the isolation of two new compounds designated as portulasoid (2) and septanoecdysone (3) along with the known 20-hydroxyecdysone (20HE) (1). Their chemical structures were elucidated on the basis of extensive spectroscopic methods including ES-HRMS, 1D and 2D-NMR. The isolated compounds were finally tested for their antioxidant activity by using DPPH, ABTS(+), Fe(3+) and catalase assays and also for their antibacterial and anticholinesterase activities.
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Septanoecdysone exhibited significant antioxidant, antibacterial, and anticholinesterase activities in vitro.
“Evaluated antioxidant activity by using DPPH, ABTS+, Fe3+ and catalase assays. Also evaluated antibacterial and anticholinesterase activities and shown significant activities.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [55]
The molecular formula of the isolated 20-HE is C27H44O7.
“A molecular formula of C27H44O7 related to 20-HE was then deduced and confirmed according to the literature [36,37,38,39].”
From Phytoecdysteroids and Anabolic Effect of Atriplex dimorphostegia: UPLC-PDA-MS/MS Profiling, In Silico and In Vivo Models (2023) · cites this paper as [36]
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The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review
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- Authors
- Ben Nejma, A., Nguir, A., Ben Jannet, H., Hamza, M. A., Daïch, A., Othman, M., & Lawson, A. M.
- Affiliations
- University of Monastir (TN)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Lawson, Ata Martin
- Venue
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 25
- Issue
- 8
- Pages
- 1665-1670
- ISSN
- 0960-894X (ISSN-L)
- OpenAlex
- W2951710799
- Cited by
- 38
- References
- 28
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 1 · 2015: 2
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioorganic & Medicinal Chemistry Letters (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Ministry of Higher Education and Scientific Research of Tunisia
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- Atriplex portulacoides, 20-hydroxyecdysone, natural product isolation, structure elucidation, antioxidant activity, antibacterial activity, anticholinesterase activity, roots, Chenopodiaceae
- MeSH terms
- Antioxidants, Cholinesterases, Ecdysterone, Gram-Negative Bacteria, Gram-Positive Bacteria, Molecular Conformation, Magnetic Resonance Spectroscopy, Plant Extracts, Protein Binding, Plant Roots, Atriplex
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