Use of clonidine in children with autism spectrum disorders

Ming, Xue; Gordon, Emily; Kang, Ning; Wagner, George C.

doi:10.1016/j.braindev.2007.12.007

Cited by 183Autism Spectrum Disorder ResearchSleep and related disordersChild Nutrition and Feeding Issues

Use of clonidine in children with autism spectrum disorders

Ming, Xue, Gordon, Emily, Kang, Ning, Wagner, George C.·2008·Brain and Development

DOI 10.1016/j.braindev.2007.12.007

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Abstract

Children with autism spectrum disorders (ASD) often exhibit sleep and behavioral disorders. Treatment of sleep disorders can be difficult in these children. Clonidine, an alpha2-adrenergic receptor agonist, has been shown to be effective in reducing impulsivity, inattention, and hyperactivity, as well as in serving as a sedative for medial procedures. An open labeled retrospective study of clonidine in treatment of insomnia, and/or hyperactivity, inattention, mood disorder, and aggressive behaviors was conducted using parent reports of sleep initiation and maintenance, as well as behaviors prior and during clonidine treatment. Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD. The side effects were largely tolerable. Further evaluation with placebo-controlled double-blind clinical trial of clonidine use in ASD will provide more insight into the clinical efficacy and safety of the medicine in ASD.

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Clonidine has been studied for sleep onset.
“Clonidine, an α2-adrenergic agonist, has been studied for sleep onset, and the long-acting preparation can be used for sleep maintenance [66].”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [66]
The long-acting clonidine formulation has not been adequately studied.
“The long-acting formulation however, has not been adequately studied and requires swallowing a pill whole [66].”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [66]
Short-acting clonidine is effective in improving sleep onset.
“Short-acting clonidine is effective in improving sleep onset.”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [66]
Long-acting clonidine preparation can be used for sleep maintenance.
“Clonidine, an α2-adrenergic agonist, has been studied for sleep onset, and the long-acting preparation can be used for sleep maintenance [66].”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [66]
The long-acting clonidine formulation requires swallowing a pill whole.
“The long-acting formulation however, has not been adequately studied and requires swallowing a pill whole [66].”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [66]

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Authors: Ming, X., Gordon, E., Kang, N., & Wagner, G. C.
Affiliations: Rutgers New Jersey Medical School (US)
University of California, Los Angeles (US)
Rutgers, The State University of New Jersey (US)
Corresponding author: Ming, Xue
ORCID: Ming, Xue
Wagner, George C.
Venue: Brain and Development
Publisher: Elsevier BV
Published: 2008-08
Volume: 30
Issue: 7
Pages: 454-460
ISSN: 0387-7604 (ISSN-L)
DOI: 10.1016/j.braindev.2007.12.007
OpenAlex: W1970038529
Cited by: 183
References: 50
Citations by year: 2026: 4 · 2025: 14 · 2024: 14 · 2023: 13 · 2022: 12 · 2021: 11 · 2020: 18 · 2019: 7 · 2018: 12 · 2017: 13 · 2016: 7 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 10
FWCI: 3.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain and Development (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords: clonidine, autism spectrum disorder, insomnia, sleep disorders, hyperactivity, inattention, mood disorders, aggression, alpha-2 adrenergic agonists, children, sedation, adverse effects
MeSH terms: Adolescent, Adrenergic alpha-Agonists, Aggression, Attention Deficit Disorder with Hyperactivity, Attitude to Health, Autistic Disorder, Child, Child, Preschool, Clonidine, Female, Humans, Hyperkinesis, Impulsive Behavior, Sleep Initiation and Maintenance Disorders, Male, Psychiatric Status Rating Scales, Retrospective Studies, Sleep Wake Disorders, Treatment Outcome, Mood Disorders

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Use of clonidine in children with autism spectrum disorders

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