Cited by 266Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesGenetics and Neurodevelopmental Disorders

Autism spectrum disorders: Concurrent clinical disorders

Xue Ming, Brimacombe, Michael, Chaaban, Janti, Zimmerman-Bier, Barbie, Wagner, George C.·2008·Journal of Child Neurology

Abstract

Individuals with autism spectrum disorder are heterogeneous in clinical presentation, concurrent disorders, and developmental outcomes. This study characterized the clinical co-occurrences and potential subgroups in 160 children with autism spectrum disorders who presented to The Autism Center between 1999 and 2003. Medical and psychiatric co-occurrences included sleep disorders, epilepsy, food intolerance, gastrointestinal dysfunction, mood disorder, and aggressive and self-injurious behaviors. Sleep disorders were associated with gastrointestinal dysfunction (P < .05) and mood disorders (P < .01). Food intolerance was associated with gastrointestinal dysfunction (P = .001). Subjects with mood disorder tended to develop aggressive or self-injurious behaviors (P < .05). Developmental regression was not associated with increased co-occurrence of medical or psychiatric disorders. Medical co-occurrence did not present as a risk factor for psychiatric co-occurrence, and vice versa. These results showed a high prevalence of multiple medical and psychiatric co-occurrences. There may be common pathophysiologic mechanisms resulting in clinical subgroups of autism spectrum disorders. Recognition of the co-occurrence of concurrent disorders may provide insight into the therapeutic strategy.

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Crossref · 10.1177/0883073807307102

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54 of 54 references verified0 citation errors · 0 not checkable

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Authors
Ming, X., Brimacombe, M., Chaaban, J., Zimmerman-Bier, B., & Wagner, G. C.
Affiliations
  • Rutgers New Jersey Medical School (US)
  • Rutgers, The State University of New Jersey (US)
Venue
Journal of Child Neurology
Published
2007-12-03
Volume
23
Issue
1
Pages
6-13
ISSN
  • 0883-0738 (ISSN-L)
  • 1708-8283
OpenAlex
W2014966922
Cited by
266
References
54
Citations by year
2026: 6 · 2025: 7 · 2024: 13 · 2023: 11 · 2022: 15 · 2021: 13 · 2020: 19 · 2019: 18 · 2018: 12 · 2017: 16 · 2016: 15 · 2015: 13 · 2014: 17 · 2013: 17 · 2012: 21
FWCI
6.49
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Child Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, sleep disorders, epilepsy, food intolerance, gastrointestinal dysfunction, mood disorders, aggression, self-harm, developmental regression, clinical subgroups, children
MeSH terms
Adolescent, Aggression, Autistic Disorder, Mental Disorders, Child, Child Behavior Disorders, Developmental Disabilities, Child, Preschool, Epilepsy, Female, Gastrointestinal Diseases, Humans, Male, Regression, Psychology, Retrospective Studies, Self Mutilation, Sleep Wake Disorders, Comorbidity, Prevalence, Mood Disorders

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