The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Role of the medial prefrontal cortex in coping and resilience
Open accessAbstract
The degree of behavioral control that an organism has over an aversive event is well known to modulate the behavioral and neurochemical consequences of exposure to the event. Here we review recent research that suggests that the experience of control over a potent stressor alters how the organism responds to future aversive events as well as to the stressor being controlled. More specifically, subjects that have experienced control show blunted behavioral and neurochemical responses to subsequent stressors occurring days to months later. Indeed, these subjects respond as if a later uncontrollable stressor is actually controllable. Further, we review research indicating that the stress resistance induced by control depends on control-induced activation of ventral medial prefrontal cortical (vmPFC) inhibitory control over brainstem and limbic structures. Furthermore, there appears to be plasticity in these circuits such that the experience of control alters the vmPFC in such a way that later uncontrollable stressors now activate the vmPFC circuitry, leading to inhibition of stress-responsive limbic and brainstem structures, i.e., stressor resistance. This controllability-induced proactive stressor resistance generalizes across very different stressors and may be involved in determining individual difference in reactions to traumatic events.
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“vmPFC inactivation abolishes all these benefits of control without affecting the learning of escape responses per se.”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [42]
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“Control speeds subsequent escape learning [40] and slows subsequent fear conditioning [41], reduces threat-related serotonin responses in the dorsal raphe to novel contexts [40], and buffers the animals against later adverse effects of inescapable shock [42].”
From Ventromedial prefrontal–subcortical systems and the generation of affective meaning (2012) · cites this paper as [42]
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Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
Coping styles in animals: current status in behavior and stress-physiology
Koolhaas, J. M., Korte, S. M., De Boer, S. F., Van Der Vegt, B. J., Van Reenen, C. G., Hopster, H., De Jong, I. C., Ruis, M. A. W., & Blokhuis, H. J. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00026-3 · Cited by 2,875 · cited 1×
“At the animal level investigators have generally distinguished between active and passive coping styles (Koolhaas et al., 1999).”
Learned helplessness: Theory and evidence
Maier, S. F., & Seligman, M. E. (1976) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.105.1.3 · Cited by 2,494
Self-citationFailure to escape traumatic shock.
Seligman, M. E., & Maier, S. F. (1967) · Journal of Experimental Psychology · doi:10.1037/h0024514 · Cited by 1,981 · cited 1×
“…our laboratory directed at these questions derives from older reports indicating that a session of ES prevented a later exposure to IS from producing shuttle box escape deficits (Seligman and Maier, 1967), even if the two experiences occurred in different environments (Williams and Maier, 1977).”
Self-citationDifferential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550
Goal-directed instrumental action: contingency and incentive learning and their cortical substrates
Balleine, B. W., & Dickinson, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00033-1 · Cited by 1,541
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The Psychobiology of Depression and Resilience to Stress: Implications for Prevention and Treatment
Southwick, S. M., Vythilingam, M., & Charney, D. S. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143948 · Cited by 1,160
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Shin, L. M., Wright, C. I., Cannistraro, P. A., Wedig, M. M., McMullin, K., Martis, B., Macklin, M. L., Lasko, N. B., Cavanagh, S. R., Krangel, T. S., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.3.273 · Cited by 960
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Sense of agency in the human brain
Haggard, P. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.14 · Cited by 1,107
Ventromedial prefrontal–subcortical systems and the generation of affective meaning
Roy, M., Shohamy, D., & Wager, T. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.01.005 · Cited by 856
A unified framework for inhibitory control
Munakata, Y., Herd, S. A., Chatham, C. H., Depue, B. E., Banich, M. T., & O’Reilly, R. C. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.011 · Cited by 699
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519
Emotion and Decision Making: Multiple Modulatory Neural Circuits
Phelps, E. A., Lempert, K. M., & Sokol‐Hessner, P. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014119 · Cited by 479
Metadata
- Authors
- Maier, S. F., & Watkins, L. R.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Maier, Steven F.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 1355
- Pages
- 52-60
- ISSN
- 0006-8993 (ISSN-L)
- PMC
- PMC2967290
- OpenAlex
- W1999655743
- Cited by
- 292
- References
- 49
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 15 · 2023: 20 · 2022: 21 · 2021: 15 · 2020: 23 · 2019: 20 · 2018: 7 · 2017: 19 · 2016: 23 · 2015: 22 · 2014: 23 · 2013: 24 · 2012: 22
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (MH50479)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- medial prefrontal cortex, stress resilience, perceived control, coping, ventromedial prefrontal cortex, inhibitory control, brainstem, limbic system, neuroplasticity, individual differences, trauma, aversive events
- MeSH terms
- Adaptation, Psychological, Animals, Brain Stem, Humans, Limbic System, Neural Inhibition, Neural Pathways, Neuronal Plasticity, Stress, Psychological, Prefrontal Cortex, Resilience, Psychological
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