Cited by 292Stress Responses and CortisolMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

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Role of the medial prefrontal cortex in coping and resilience

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Maier, Steven F., Watkins, Linda R.·2010·Brain Research

DOI 10.1016/j.brainres.2010.08.039PMC PMC2967290

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Abstract

The degree of behavioral control that an organism has over an aversive event is well known to modulate the behavioral and neurochemical consequences of exposure to the event. Here we review recent research that suggests that the experience of control over a potent stressor alters how the organism responds to future aversive events as well as to the stressor being controlled. More specifically, subjects that have experienced control show blunted behavioral and neurochemical responses to subsequent stressors occurring days to months later. Indeed, these subjects respond as if a later uncontrollable stressor is actually controllable. Further, we review research indicating that the stress resistance induced by control depends on control-induced activation of ventral medial prefrontal cortical (vmPFC) inhibitory control over brainstem and limbic structures. Furthermore, there appears to be plasticity in these circuits such that the experience of control alters the vmPFC in such a way that later uncontrollable stressors now activate the vmPFC circuitry, leading to inhibition of stress-responsive limbic and brainstem structures, i.e., stressor resistance. This controllability-induced proactive stressor resistance generalizes across very different stressors and may be involved in determining individual difference in reactions to traumatic events.

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Authors: Maier, S. F., & Watkins, L. R.
Affiliations: University of Colorado Boulder (US)
Corresponding author: Maier, Steven F.
ORCID: Maier, Steven F.
Watkins, Linda R.
Venue: Brain Research
Publisher: Elsevier BV
Published: 2010-10
Volume: 1355
Pages: 52-60
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2010.08.039
PMC: PMC2967290
OpenAlex: W1999655743
Cited by: 292
References: 49
Citations by year: 2026: 12 · 2025: 14 · 2024: 15 · 2023: 20 · 2022: 21 · 2021: 15 · 2020: 23 · 2019: 20 · 2018: 7 · 2017: 19 · 2016: 23 · 2015: 22 · 2014: 23 · 2013: 24 · 2012: 22
FWCI: 7.79
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (MH50479)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: medial prefrontal cortex, stress resilience, perceived control, coping, ventromedial prefrontal cortex, inhibitory control, brainstem, limbic system, neuroplasticity, individual differences, trauma, aversive events
MeSH terms: Adaptation, Psychological, Animals, Brain Stem, Humans, Limbic System, Neural Inhibition, Neural Pathways, Neuronal Plasticity, Stress, Psychological, Prefrontal Cortex, Resilience, Psychological

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Role of the medial prefrontal cortex in coping and resilience

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