Cited by 164Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersAction Observation and Synchronization

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von Economo neurons in autism: A stereologic study of the frontoinsular cortex in children

Santos, Micaela, Uppal, Neha, Butti, Camilla, Wicinski, Bridget, Schmeidler, James, Giannakopoulos, Panteleimon, Heinsen, Helmut, Schmitz, Christoph, Hof, Patrick R.·2011·Brain Research

DOI 10.1016/j.brainres.2010.08.067

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Abstract

The presence of von Economo neurons (VENs) in the frontoinsular cortex (FI) has been linked to a possible role in the integration of bodily feelings, emotional regulation, and goal-directed behaviors. They have also been implicated in fast intuitive evaluation of complex social situations. Several studies reported a decreased number of VENs in neuropsychiatric diseases in which the "embodied" dimension of social cognition is markedly affected. Neuropathological analyses of VENs in patients with autism are few and did not report alterations in VEN numbers. In this study we re-evaluated the possible presence of changes in VEN numbers and their relationship with the diagnosis of autism. Using a stereologic approach we quantified VENs and pyramidal neurons in layer V of FI in postmortem brains of four young patients with autism and three comparably aged controls. We also investigated possible autism-related differences in FI layer V volume. Patients with autism consistently had a significantly higher ratio of VENs to pyramidal neurons (p=0.020) than control subjects. This result may reflect the presence of neuronal overgrowth in young patients with autism and may also be related to alterations in migration, cortical lamination, and apoptosis. Higher numbers of VENs in the FI of patients with autism may also underlie a heightened interoception, described in some clinical observations.

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Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065
Untitled work
(1943) · The Nervous child · Cited by 8,870
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657
Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994
A unifying view of the basis of social cognition
GALLESE, V, KEYSERS, C., & RIZZOLATTI, G. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.07.002 · Cited by 2,236
Greenfield's Neuropathology
(1964) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1964.tb115841.x · Cited by 1,411
Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen
Economo, C. V., & Koskinas, G. N. (1925) · Springer eBooks · Cited by 1,234
On Human Symbiosis and the Vicissitudes of Individuation
Mahler, M. S. (1967) · Journal of the American Psychoanalytic Association · doi:10.1177/000306516701500401 · Cited by 1,170
Evidence of Brain Overgrowth in the First Year of Life in Autism
Courchesne, E. (2003) · JAMA · doi:10.1001/jama.290.3.337 · Cited by 1,120
A clinicopathological study of autism
Bailey, A. (1998) · Brain · doi:10.1093/brain/121.5.889 · Cited by 1,083

Show all 74 references

Research works printed but not linked: 3

Mahler, 1968, Vol. 1
Meltzer, 1980, Sulla imaginazione [On imagination], Q. Psychother. Infant., 3, 134
Rose, 1928, Die Inselrinde des Menschen und der Tiere, J. Psychol. Neurol., 37, 467

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Authors: Santos, M., Uppal, N., Butti, C., Wicinski, B., Schmeidler, J., Giannakopoulos, P., Heinsen, H., Schmitz, C., & Hof, P. R.
Affiliations: University Hospital of Geneva (CH)
Icahn School of Medicine at Mount Sinai (US)
University of Würzburg (DE)
Anatomische Anstalt (DE)
Corresponding author: Hof, Patrick R.
ORCID: Wicinski, Bridget
Schmeidler, James
Heinsen, Helmut
Schmitz, Christoph
Hof, Patrick R.
Venue: Brain Research
Publisher: Elsevier BV
Published: 2011-03
Volume: 1380
Pages: 206-217
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2010.08.067
OpenAlex: W2066612174
Cited by: 164
References: 74
Citations by year: 2026: 6 · 2025: 6 · 2024: 3 · 2023: 6 · 2022: 9 · 2021: 7 · 2020: 8 · 2019: 13 · 2018: 10 · 2017: 11 · 2016: 9 · 2015: 10 · 2014: 17 · 2013: 18 · 2012: 17
FWCI: 9.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: Autism Speaks (AS6288)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
Keywords: von Economo neurons, autism spectrum disorder, frontoinsular cortex, pyramidal neurons, layer V, interoception, social cognition, cortical lamination, neuronal migration, apoptosis, postmortem brain
MeSH terms: Adolescent, Autistic Disorder, Cell Count, Cerebral Cortex, Child, Child, Preschool, Female, Frontal Lobe, Humans, Male, Neurons, Pyramidal Cells, Cell Shape

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von Economo neurons in autism: A stereologic study of the frontoinsular cortex in children

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