The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Reduced GABAA receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism
Open accessAbstract
Individuals with autism display deficits in the social domain including the proper recognition of faces and interpretations of facial expressions. There is an extensive network of brain regions involved in face processing including the fusiform gyrus (FFG) and posterior cingulate cortex (PCC). Functional imaging studies have found that controls have increased activity in the PCC and FFG during face recognition tasks, and the FFG has differential responsiveness in autism when viewing faces. Multiple lines of evidence have suggested that the GABAergic system is disrupted in the brains of individuals with autism and it is likely that altered inhibition within the network influences the ability to perceive emotional expressions. On-the-slide ligand binding autoradiography was used to determine if there were alterations in GABAA and/or benzodiazepine binding sites in the brain in autism. Using 3H-muscimol and 3H-flunitrazepam we could determine whether the number (Bmax), binding affinity (Kd), and/or distribution of GABAA receptors and its benzodiazepine binding sites (BZD) differed from controls in the FFG and PCC. Significant reductions in the number of GABAA receptors and BZD binding sites in the superficial layers of the PCC and FFG, and in the number of BZD binding sites were found in the deep layers of the FFG. In addition, the autism group had a higher binding affinity in the superficial layers of the GABAA study. Taken together, these findings suggest that the disruption in inhibitory control in the cortex may contribute to the core disturbances of socio-emotional behaviors in autism.
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Cites
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Background
Cited by
Interneuron dysfunction in psychiatric disorders
Marín, O. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3155 · Cited by 1,190
GABAergic Interneurons Shape the Functional Maturation of the Cortex
Le Magueresse, C., & Monyer, H. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.011 · Cited by 425
The Default Mode Network in Autism
Padmanabhan, A., Lynch, C. J., Schaer, M., & Menon, V. (2017) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.04.004 · Cited by 375
Altered neural connectivity in excitatory and inhibitory cortical circuits in autism
Zikopoulos, B., & Barbas, H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00609 · Cited by 313
Reduced GABAergic Action in the Autistic Brain
Robertson, C. E., Ratai, E.-M., & Kanwisher, N. (2016) · Current Biology · doi:10.1016/j.cub.2015.11.019 · Cited by 327
Metadata
- Authors
- Oblak, A. L., Gibbs, T. T., & Blatt, G. J.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 1380
- Pages
- 218-228
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2091038318
- Cited by
- 175
- References
- 20
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- green
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