Distinct roles of the hippocampus and perirhinal cortex in GABAA receptor blockade-induced enhancement of object recognition memory
Abstract
It is well known that the hippocampus plays a role in spatial and contextual memory, and that spatial information is tightly regulated by the hippocampus. However, it is still highly controversial whether the hippocampus plays a role in object recognition memory. In a pilot study, the administration of bicuculline, a GABAA receptor antagonist, enhanced memory in the passive avoidance task, but not in the novel object recognition task. In the present study, we hypothesized that these different results are related to the characteristics of each task and the different roles of hippocampus and perirhinal cortex. A region-specific drug-treatment model was employed to clarify the role of the hippocampus and perirhinal cortex in object recognition memory. After a single habituation in the novel object recognition task, intra-perirhinal cortical injection of bicuculline increased and intra-hippocampal injection decreased the exploration time ratio to novel object. In addition, when animals were repeatedly habituated to the context, intra-perirhinal cortical administration of bicuculline still increased exploration time ratio to novel object, but the effect of intra-hippocampal administration disappeared. Concurrent increases of c-Fos expression and ERK phosphorylation were observed in the perirhinal cortex of the object with context-exposed group either after single or repeated habituation to the context, but no changes were noted in the hippocampus. Altogether, these results suggest that object recognition memory formation requires the perirhinal cortex but not the hippocampus, and that hippocampal activation interferes with object recognition memory by the information encoding of unfamiliar environment.
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The hippocampus is undoubtedly important for NOP memory when the retention is over 10 minutes, while its involvement likely depends on contextual novelty, features of context, and probably allocentric signals.
“Thus, the hippocampus is undoubtedly important for NOP memory when the retention is over 10 minutes (Cohen and Stackman, 2015), while its involvement likely depends on contextual novelty (Kim et al., 2014; Oliveira et al., 2010; Yi et al., 2016), features of context (Piterkin et al., 2008), and probably allocentric signals (Langston and Wood, 2010) (see below).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Kim et al., 2014
Post-sample infusions of muscimol and the GABAa-R antagonist bicuculline into the dorsal hippocampus respectively facilitated and disrupted long-term NOP memory in a less-habituated environment, but not after sufficient habituation.
“Interestingly, post-sample infusions of muscimol and the GABAa-R antagonist bicuculline into the dorsal hippocampus respectively facilitated and disrupted long-term NOP memory in a less-habituated environment, but not after sufficient habituation (Kim et al., 2014; Oliveira et al., 2010).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Kim et al., 2014
A non-effect of pharmacological inactivation on the dorsal hippocampus was reported in the NOP test if animals were well-habituated to the testing environment.
“However, a non-effect of pharmacological inactivation on the dorsal hippocampus was reported in the NOP test if animals were well-habituated to the testing environment (Kim et al., 2014; Oliveira et al., 2010).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Kim et al., 2014
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- Authors
- Kim, J. M., Kim, D. H., Lee, Y., Park, S. J., & Ryu, J. H.
- Affiliations
- Kyung Hee University (KR)
- Corresponding author
- Ryu, Jong Hoon
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 1552
- Pages
- 17-25
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2078414300
- Cited by
- 35
- References
- 39
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 8 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 2
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Science and Technology (2012R1A2A2A02012332)
- National Research Foundation of Korea
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- object recognition memory, hippocampus, perirhinal cortex, GABAA inhibition, bicuculline, novel object recognition, contextual memory, Fos expression, ERK1/2 phosphorylation, hippocampal activation, memory interference, spatial memory
- MeSH terms
- Animals, Bicuculline, Exploratory Behavior, Habituation, Psychophysiologic, Hippocampus, Male, Nerve Tissue Proteins, Organ Specificity, Phosphorylation, Protein Processing, Post-Translational, Receptors, GABA-A, Proto-Oncogene Proteins c-fos, Genes, fos, Rats, Sprague-Dawley, Parahippocampal Gyrus, Recognition, Psychology, Extracellular Signal-Regulated MAP Kinases, Rats, GABA-A Receptor Antagonists
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