Cited by 71Dementia and Cognitive Impairment ResearchEEG and Brain-Computer InterfacesAlzheimer's disease research and treatments

Cognitive MMN and P300 in mild cognitive impairment and Alzheimer’s disease: a high density EEG-3D vector field tomography approach

Papadaniil, Chrysa D., Kosmidou, Vasiliki E., Tsolaki, Anthoula, Tsolaki, Magda, Kompatsiaris, Ioannis (Yiannis), Hadjileontiadis, Leontios J.·2016·Brain Research

Abstract

Precise preclinical detection of dementia for effective treatment and stage monitoring is of great importance. Miscellaneous types of biomarkers, e.g., biochemical, genetic, neuroimaging, and physiological, have been proposed to diagnose Alzheimer's disease (AD), the usual suspect behind manifested cognitive decline, and mild cognitive impairment (MCI), a neuropathology prior to AD that does not affect cognitive functions. Event related potential (ERP) methods constitute a non-invasive, inexpensive means of analysis and have been proposed as sensitive biomarkers of cognitive impairment; besides, various ERP components are strongly linked with working memory, attention, sensory processing and motor responses. In this study, an auditory oddball task is employed, to acquire high density electroencephalograhy recordings from healthy elderly controls, MCI and AD patients. The mismatch negativity (MMN) and P300 ERP components are then extracted and their relationship with neurodegeneration is examined. Then, the neural activation at these components is reconstructed using the 3D vector field tomography (3D-VFT) inverse solution. The results reveal a decline of both ERPs amplitude, and a statistically significant prolongation of their latency as cognitive impairment advances. For the MMN, higher brain activation is usually localized in the inferior frontal and superior temporal gyri in the controls. However, in AD, parietal sites exhibit strong activity. Stronger P300 generators are mostly found in the frontal lobe for the controls, but in AD they often shift to the temporal lobe. Reduction in inferior frontal source strength and the switch of the maximum intensity area to parietal and superior temporal sites suggest that these areas, especially the former, are of particular significance when neurodegenerative disorders are investigated. The modulation of MMN and P300 can serve to produce biomarkers of dementia and its progression, and brain imaging can further contribute to the diagnostic efficiency of ERPs.

Integrity signals

Registry

Crossref · 10.1016/j.brainres.2016.07.043

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

2 of the 60 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Papadaniil, C. D., Kosmidou, V. E., Tsolaki, A., Tsolaki, M., Kompatsiaris, I. (., & Hadjileontiadis, L. J.
Affiliations
  • Aristotle University of Thessaloniki (GR)
  • Information Technologies Institute (GR)
Corresponding author
  • Papadaniil, Chrysa D.
  • Hadjileontiadis, Leontios J.
Venue
Brain Research
Publisher
Elsevier BV
Published
2016-10
Volume
1648
Issue
Pt A
Pages
425-433
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2496393055
Cited by
71
References
60
Citations by year
2026: 4 · 2025: 13 · 2024: 12 · 2023: 7 · 2022: 8 · 2021: 12 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 2
FWCI
2.97
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
ARISTEIA (440)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
mismatch negativity, P300, mild cognitive impairment, Alzheimer's disease, auditory oddball paradigm, event-related potentials, EEG source localization, dementia biomarkers, inferior frontal gyrus, superior temporal gyrus, parietal activation, neurodegeneration
MeSH terms
Acoustic Stimulation, Aged, Alzheimer Disease, Auditory Perception, Cerebral Cortex, Electroencephalography, Evoked Potentials, Auditory, Female, Frontal Lobe, Humans, Male, Middle Aged, Parietal Lobe, Temporal Lobe, Biomarkers, Disease Progression, Event-Related Potentials, P300, Cognitive Dysfunction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review