Cited by 70Dementia and Cognitive Impairment ResearchEEG and Brain-Computer InterfacesAlzheimer's disease research and treatments

Brain source localization of MMN and P300 ERPs in mild cognitive impairment and Alzheimer’s disease: a high-density EEG approach

Tsolaki, Anthoula C., Kosmidou, Vasiliki, Kompatsiaris, Ioannis (Yiannis), Papadaniil, Chrysa, Hadjileontiadis, Leontios, Adam, Aikaterini, Tsolaki, Magda·2017·Neurobiology of Aging

Abstract

Alzheimer's disease is the most common neurodegenerative disease of Western societies, suggesting the need for early diagnosis, even in preclinical stages. In this vein, the localization of neuronal generators of event-related potential (ERP) components, that is, the mismatch negativity and the P300, based on high-density electroencephalogram data, was explored as a means to enhance their sensitivity as markers of preclinical Alzheimer's disease (AD). A 2-tone oddball experiment was conducted, involving 21 healthy elderly, 21 mild cognitive impairment, and 21 mild AD patients, while high-density electroencephalogram data were recorded. The results revealed longer latencies of both mismatch negativity and P300 and slower and far less accurate responses as neurodegeneration progressed. Standardized low-resolution electromagnetic tomography revealed that source differences between healthy and mild cognitive impairment and healthy and AD patients for both ERP components were present in the same Brodmann area independently of the ERP and the stage of cognitive decline. This finding indicates an early change of source activation related to cognitive performance and may be used to improve the diagnostic and prognostic value of ERPs.

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Crossref · 10.1016/j.neurobiolaging.2017.03.025

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  • Previous literature supports that individuals with Alzheimer's disease have impaired predictive processes.

    “previous literature supporting the fact that individuals with Alzheimer ' s disease have impaired pre­ dictive processes (Papadaniil et al., 2016; Tsolaki et al., 2017).”

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Authors
Tsolaki, A. C., Kosmidou, V., Kompatsiaris, I. (., Papadaniil, C., Hadjileontiadis, L., Adam, A., & Tsolaki, M.
Affiliations
  • Aristotle University of Thessaloniki (GR)
  • Information Technologies Institute (GR)
  • Khalifa University of Science and Technology (AE)
Corresponding author
Tsolaki, Anthoula C.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2017-07
Volume
55
Pages
190-201
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2601027128
Cited by
70
References
124
Citations by year
2026: 6 · 2025: 9 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 14 · 2020: 8 · 2019: 7 · 2018: 9
FWCI
5.39
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
mismatch negativity, P300, event-related potentials, mild cognitive impairment, Alzheimer's disease, preclinical Alzheimer's disease, brain source localization, high-density EEG, oddball paradigm, ERP latency, early diagnosis, cognitive decline
MeSH terms
Aged, Alzheimer Disease, Cognition, Electroencephalography, Female, Humans, Male, Middle Aged, Event-Related Potentials, P300, Cognitive Dysfunction

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