Auditory Memory Decay as Reflected by a New Mismatch Negativity Score Is Associated with Episodic Memory in Older Adults at Risk of Dementia
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The mismatch negativity (MMN) is an event-related potential peaking about 100-250 ms after a deviant onset in a sequence of identical (standard) tones. Depending on the interstimulus interval (ISI) between standard and deviant tones, the MMN is suitable to investigate pre-attentiveautomatic auditory discrimination ability (short ISIs, ≤ 2 s) as well as pre-attentive auditory memory trace (long ISIs, > 2 s). However, current results regarding the MMN as a biomarker for mild cognitive impairment and dementia are mixed, especially after short ISIs: while the majority of studies report positive associations between MMN and cognition, others fail to find such relationships. To elucidate these so far inconsistent results, we investigated the validity of the MMN as a biomarker for cognitive impairment exploring the associations between different MMN indices and cognitive performance, especially episodic memory as a core symptom of Alzheimer’s dementia, at baseline and at a 5-year follow-up. We assessed the amplitude of the MMN for short ISIs (stimulus onset asynchrony, SOA = 0.05 s) and for long ISIs (3 s) in a neuropsychologically well-characterized cohort of older adults at risk of dementia (subjective memory impairment, amnestic and non-amnestic mild cognitive impairment; n = 57). Furthermore, we created a novel difference score (ΔMMN), defined as the difference between MMNs to short and to long ISIs, as a measure to assess the decay of the auditory memory trace. ΔMMN and MMN amplitude after long ISIs, but not the MMN amplitude after short ISIs, was positively associated with episodic memory at baseline (β = 0.38, p = 0.003; β = -0.27, p = 0.47, respectively). ΔMMN, but not the MMN for long ISIs, was also positively associated with episodic memory performance at the 5-year follow-up (β = 0.57, p = 0.013). The results suggest that the MMN after long ISIs might be suitable as an indicator for the decline in episodic memory and indicate ΔMMN as a potential biomarker for memory impairment in older adults at risk of dementia.
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The mismatch response is correlated with episodic memory in people at risk of AD.
“it is correlated with episodic memory in people at risk of AD 36 , 37”
From Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity (2025) · cites this paper as [36]
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Mismatch negativity as a marker of auditory pattern separation
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An Empirical Study on Challenges Faced by the Elderly in Care Centres
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“34,35 Although the mismatch response does not directly probe episodic memory, it is correlated with episodic memory in people at risk of AD 36,37 and is reduced by fibrillary A β in preclinical models.”
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- Authors
- Laptinskaya, D., Thurm, F., Küster, O. C., Fissler, P., Schlee, W., Kolassa, S., von Arnim, C. A. F., & Kolassa, I.-T.
- Affiliations
- University of Konstanz (DE)
- Universität Ulm (DE)
- University Hospital Regensburg (DE)
- Systems, Applications & Products in Data Processing (Switzerland) (CH)
- Corresponding author
- Laptinskaya, Daria
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-02-02
- Volume
- 10
- Pages
- 5-5
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC5801314
- OpenAlex
- W2788313932
- Cited by
- 31
- References
- 82
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 4 · 2019: 2
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- KOPS (University of Konstanz) (submittedVersion, cc-by)
- OPen Access Repositorium der Universität Ulm (OPARU) (Ulm University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Lancaster EPrints (Lancaster University) (submittedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- Universität Ulm, Kommunikations- und Informationszentrum (kiz) (cc-by)
- Funders
- Helsingin Yliopisto
- Heidelberger Akademie der Wissenschaften
- Universität Konstanz
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- mismatch negativity, episodic memory, dementia risk, mild cognitive impairment, Alzheimer's disease, biomarkers, interstimulus interval, subjective memory impairment, older adults, memory decline, event-related potentials
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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