Cited by 122Nerve injury and regenerationNeuroprotection in Cerebral IschemiaNuclear Receptors and Signaling

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Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: Recent developments

Zhao, Hailin, Alam, Azeem, San, Chun-Yin, Eguchi, Shiori, Chen, Qian, Lian, Qingquan, Ma, Daqing·2017·Brain Research

DOI 10.1016/j.brainres.2017.03.029

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Abstract

Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a significant cause of mortality around the world. On a molecular level, the condition is characterized by widespread cell death and poor regeneration, which can result in severe morbidity in survivors. Potential therapeutics are of major interest, with a promising candidate being brain-derived neurotrophic factor (BDNF), a ubiquitous agent in the brain which has been associated with neural development and may facilitate protective and regenerative effects following injury. This review summarizes the available information on the potential benefits of BDNF and the molecular mechanisms involved in several pathological conditions, including hypoxic brain injury, stroke, Alzheimer's disease and Parkinson's disease. It further explores the methods in which BDNF can be applied in clinical and therapeutic settings, and the potential challenges to overcome.

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BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
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Authors: Zhao, H., Alam, A., San, C.-Y., Eguchi, S., Chen, Q., Lian, Q., & Ma, D.
Affiliations: Chelsea and Westminster Hospital (GB)
Army Medical University (CN)
Wenzhou Medical University (CN)
Corresponding author: Lian, Qingquan
Ma, Daqing
ORCID: Zhao, Hailin
Alam, Azeem
Eguchi, Shiori
Chen, Qian
Ma, Daqing
Venue: Brain Research
Publisher: Elsevier BV
Published: 2017-06
Volume: 1665
Pages: 1-21
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2017.03.029
OpenAlex: W2604803509
Cited by: 122
References: 340
Citations by year: 2026: 5 · 2025: 12 · 2024: 9 · 2023: 7 · 2022: 16 · 2021: 11 · 2020: 14 · 2019: 22 · 2018: 17 · 2017: 9
FWCI: 2.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: Sparks
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: brain-derived neurotrophic factor, neuroprotection, neuronal cell death, neurological trauma, hypoxic brain injury, stroke, Alzheimer's disease, Parkinson's disease, nerve regeneration, therapeutic target
MeSH terms: Alzheimer Disease, Animals, Brain, Hypoxia, Brain, Humans, Neurons, Parkinson Disease, Brain-Derived Neurotrophic Factor

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Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: Recent developments

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