Striatal dopamine transporter binding correlates with serum BDNF levels in patients with striatal dopaminergic neurodegeneration
Abstract
Compelling evidence has shown, that neurotrophins responsible for the regulation of neuronal growth, survival, and differentiation are involved in neurodegenerative diseases. Whereas lower serum levels of brain derived neurotrophic factor (BDNF) have been observed in patients with Parkinson's disease, no studies have directly related the degree of striatal neurodegeneration of dopaminergic neurons (DA) with serum BDNF levels. In this study we examined the relationship between striatal neurodegeneration as determined with (123)I-PE2I-single photon emission computer tomography (SPECT) and serum BDNF levels in patients with parkinsonism. Twenty-one patients with abnormal in vivo striatal dopamine transporter (DAT) binding as evidenced with [(123)I]PE2I SPECT brain scanning were included. Samples for serum BDNF levels were collected at the time of the SPECT scanning, and BDNF was measured with enzyme-linked immunosorbent assay (ELISA). The striatal binding potential of non-displaceable [(123)I]PE2I was calculated. We found a positive correlation between serum BDNF levels and striatal DAT availability (p < 0.01, R(2) = 0.36). We find that in patients with striatal dopaminergic neurodegeneration serum BDNF levels decrease along with loss in striatal DAT binding.
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In patients with striatal dopaminergic neurodegeneration, serum BDNF levels decrease along with loss of the striatal dopamine transporter.
“In addition, Ziebell et al. [74] have found that in patients with striatal dopaminergic neurodegeneration, serum BDNF levels decrease along with loss of the striatal dopamine transporter (DAT).”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [74]
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- Authors
- Ziebell, M., Khalid, U., Klein, A. B., Aznar, S., Thomsen, G., Jensen, P., & Knudsen, G. M.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Knudsen, Gitte M.
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 33
- Issue
- 2
- Pages
- 428.e1-428.e5
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2005965990
- Cited by
- 62
- References
- 38
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 3 · 2014: 3 · 2013: 4
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Funders
- Lundbeckfonden (R62-2010-5364, R90-2011-7722)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- brain-derived neurotrophic factor, serum BDNF, striatal dopamine transporter, dopaminergic neuron loss, Parkinson's disease, parkinsonism, striatal dopamine transporter binding, neurotrophins, neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Corpus Striatum, Dopamine, Female, Humans, Male, Metabolic Clearance Rate, Middle Aged, Parkinson Disease, Protein Binding, Statistics as Topic, Tissue Distribution, Brain-Derived Neurotrophic Factor, Dopamine Plasma Membrane Transport Proteins, Dopaminergic Neurons
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