Seizure susceptibility in the APP/PS1 mouse model of Alzheimer’s disease and relationship with amyloid β plaques
Abstract
Alzheimer's disease is a common age associated neurodegenerative disorder associated with an elevated risk of seizures that may be fundamentally connected to cognitive dysfunction. We used 4-9month-old mice of the APP/PS1 mouse model of Alzheimer's disease to study the presence of epileptiform-like discharges and to establish if the amyloid-β plaques affect their generation. The EEG of the APP/PS1 transgenic mice revealed a higher incidence of epileptiform-like discharges i.e. seizure events (interictal spikes, sharp waves, or polyspikes) than in the controls. Also, APP/PS1 mice showed a lower latency to evoke seizure events than in the control animals when pentylenetetrazole (60mg/kg; i.p.) was injected. Moreover, physostigmine injection (1mg/kg; i.p.) also increased the frequency of spontaneous epileptiform-like discharges in the APP/PS1 mice. We also found a correlation between the frequency of epileptiform-like discharges and the number of amyloid-β plaques. Application of N-(2-chloroethyl)-N-ethyl-bromobenzylamine (50mg/kg) generated amyloid-β plaques in the cortex and seizure activity appeared. Taken together, these data indicate that deposits of amyloid-β plaques may be responsible for the epileptiform-like discharges recorded in the APP/PS1 mice and could be responsible for the elevated risk for seizures of Alzheimer's patients.
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Hyperexcitability and seizures were observed as early as 4.5 months of age in APP/PS1 mice.
“Hyperexcitability and seizures were observed as early as 4.5 months of age in APP/PS1 mice [37].”
From Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures (2023) · cites this paper as [37]
APP/PS1 mice have a lower seizure threshold when challenged with chemoconvulsants and higher susceptibility to spontaneous seizures compared to age-matched wild-type mice.
“Moreover, APP/PS1 mice present with a lower seizure threshold when challenged with chemoconvulsants along with a higher susceptibility to spontaneous seizures compared to age-matched wild-type mice [66].”
From Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures (2023) · cites this paper as [66]
In APP/PS1 mice, plaque number strongly correlates with increased seizure severity.
“Specifically, there is a strong correlation between plaque number and the increase of seizure severity in mice overexpressing human APP (APP/PS1) [66].”
From Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures (2023) · cites this paper as [66]
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A bibliometric analysis of synaptic plasticity and epilepsy from 2003 to 2023
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40 Hz-rTMS modulates spike-LFP coupling and improves cognitive function in 5xFAD mice
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The Aging Brain and Epilepsy: Current Knowledge and Novel Therapeutic Targets
Löscher, W., & Forcelli, P. A. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100168
- Authors
- Reyes-Marin, K. E., & Nuñez, A.
- Affiliations
- Universidad Autónoma de Madrid (ES)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 1677
- Pages
- 93-100
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2760503366
- Cited by
- 84
- References
- 50
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 16 · 2023: 6 · 2022: 8 · 2021: 25 · 2020: 4 · 2019: 8 · 2018: 1
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Economia y Competitividad
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, seizure susceptibility, APP/PS1 mice, amyloid plaques, epileptiform discharges, EEG, pentylenetetrazole, physostigmine, amyloid-beta deposition
- MeSH terms
- Electrocorticography, Alzheimer Disease, Animals, Benzylamines, Cerebral Cortex, Disease Models, Animal, Disease Susceptibility, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Pentylenetetrazole, Physostigmine, Seizures, Plaque, Amyloid
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