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Cited by 136Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Diminished perisomatic GABAergic terminals on cortical neurons adjacent to amyloid plaques

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Garcia-Marin, Virginia·2009·Frontiers in Neuroanatomy
DOI 10.3389/neuro.05.028.2009PMC PMC2784678
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Abstract

One of the main pathological hallmarks of Alzheimer's disease (AD) is the accumulation of plaques in the cerebral cortex, which may appear either in the neuropil or in direct association with neuronal somata. Since different axonal systems innervate the dendritic (mostly glutamatergic) and perisomatic (mostly GABAergic) regions of neurons, the accumulation of plaques in the neuropil or associated with the soma might produce different alterations to synaptic circuits. We have used a variety of conventional light, confocal and electron microscopy techniques to study their relationship with neuronal somata in the cerebral cortex from AD patients and APP/PS1 transgenic mice. The main finding was that the membrane surfaces of neurons (mainly pyramidal cells) in contact with plaques lack GABAergic perisomatic synapses. Since these perisomatic synapses are thought to exert a strong influence on the output of pyramidal cells, their loss may lead to the hyperactivity of the neurons in contact with plaques. These results suggest that plaques modify circuits in a more selective manner than previously thought.

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  • The course such diseases take is highly variable as the neuropathological changes are not homogenous, neither among patients nor in different regions of the brain of the same patient, giving rise to variation in the alterations to cortical circuits.

    “In addition, the course such diseases take is highly variable as the neuropathological changes are not homogenous, neither among patients nor in different regions of the brain of the same patient, giving rise to variation in the alterations to cortical circuits (Garcia-Marin et al., 2009; Blazquez-Llorca et al., 2010).”

    From The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease (2013) · cites this paper as Garcia-Marin et al., 2009

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Authors
Garcia-Marin, V.
Venue
Frontiers in Neuroanatomy
Publisher
Frontiers Media SA
Published
2009
Volume
3
Pages
28-28
ISSN
1662-5129 (ISSN-L)
DOI
10.3389/neuro.05.028.2009
PMC
PMC2784678
OpenAlex
W2153628730
Cited by
136
References
11
Citations by year
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FWCI
1.68
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Frontiers in Neuroanatomy (publishedVersion, other-oa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
Funders
  • “la Caixa” Foundation
  • Ministerio de Ciencia y Tecnología
  • Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CB06/05/0066)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, amyloid plaques, GABAergic synapses, cortical pyramidal neurons, APP/PS1 mice, neuronal hyperactivity, cerebral cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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