The DOI matches its Crossref record; 143 of the 144 references it cites were found in a registry or an index.
Contributions of astrocytes to synapse formation and maturation — Potential functions of the perisynaptic extracellular matrix
Abstract
The concept of the tripartite synapse proposes that in addition to the presynapse and the postsynaptic membrane closely apposed processes of astrocytes constitute an integral part of the synapse. Accordingly, astrocytes may influence synaptic activity by various ways. Thus glia- and neuron-derived neurotrophins, cytokines and metabolites influence neuronal survival, synaptic activity and plasticity. Beyond these facts, the past years have shown that astrocytes are required for synaptogenesis, the structural maintenance and proper functioning of synapses. In particular, astrocytes seem to play a key role in the organization of the brain's extracellular matrix (ECM) - most prominently the so-called perineuronal nets (PNNs), complex macromolecular assemblies of ECM components. Due to progress in cellular and molecular neurosciences, it has been possible to decipher the composition of ECM structures and to obtain insight into their function(s) and underlying mechanisms. It appears that PNN-related structures are involved in regulating the sprouting and pruning of synapses, which represents an important morphological correlate of synaptic plasticity in the adult nervous system. Perturbation assays and gene elimination by recombinant techniques have provided clear indications that astrocyte-derived ECM components, e.g. the tenascins and chondroitinsulfate proteoglycans (CSPGs) of the lectican family participate in these biological functions. The present review will discuss the glia-derived glycoproteins and CSPGs of the perisynaptic ECM, their neuronal and glial receptors, and in vitro assays to test their physiological functions in the framework of the synapse, the pivotal element of communication in the central nervous system.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This process is critically dependent on glial cells, which secrete and organize CSPGs and other ECM molecules.35, 36, 37”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [35]
In the citing paper
“Furthermore, aggrecan and CS-6 expression in glial cells are involved in the regulation of astrocyte maturation, which, in turn, has a key role in PNN formation and maintenance.35, 49”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [35]
In the citing paper
“These findings are not easily reconciled with sharp reductions of WFA-positive PNNs, because glial cells represent a main source of CSPGs and other PNN components.35, 37, 99”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [35]
In the citing paper
“A juvenile form of ECM, supportive of neurogenesis, cell migration, axonal outgrowth and synaptogenesis, is substituted by an adult form, which predominantly restricts plasticity (Bandtlow and Zimmermann, 2000; Faissner et al., 2010; Fawcett, 2009; Galtrey and Fawcett, 2007).”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Faissner et al., 2010
In the citing paper
“Glial cells are a main source of chondroitin sulfate proteoglycans (abbreviated here as CSPGs), and have been shown to critically contribute to the formation and maintenance of PNNs (Faissner et al., 2010; John et al., 2006; Klausmeyer et al., 2011; Wiese et al., 2012).”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Faissner et al., 2010
Citations
Cites
The Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,311
Tripartite synapses: glia, the unacknowledged partner
Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01349-6 · Cited by 2,529
CNS synaptogenesis promoted by glia-derived cholesterol
Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679
DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION
Sanes, J. R., & Lichtman, J. W. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.389 · Cited by 1,532
Glia: listening and talking to the synapse
Haydon, P. G. (2001) · Nature reviews. Neuroscience · doi:10.1038/35058528 · Cited by 1,454
Astroglia induce neurogenesis from adult neural stem cells
Song, H., Stevens, C. F., & Gage, F. H. (2002) · Nature · doi:10.1038/417039a · Cited by 1,452
Control of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380
Flagged first, then by citations
1 of the 144 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–207 of 207
A study of neurodegeneration and neuroprotection in Nothobranchius guentheri
Genade, T. (2012) · Open University of Cape Town (University of Cape Town)
Presynaptic mechanisms of short-term plasticity at hippocampal mossy fibersynapses
Llinares, B. G. I. (2014) · theses.fr (ABES) · doi:10.70675/260d23d6z0385z420bz9500z71856e7257bd
Devienne, G. F. (2019) · theses.fr (ABES) · doi:10.70675/453418efzc908z49e0zba6fz71fefaa50691
Neurovascular unit changes after juvenile traumatic brain injury
Ichkova, A. (2019) · theses.fr (ABES) · doi:10.70675/7dacb9e2z3b14z4c14zbdafzbdcfad78c341
Fujita, K., Zhu, H., Tsuji, C., Kawamura, A., Nishiyama, M., Higashida, H., & Yokoyama, S. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03952-4
Wang, Y., Liang, C., Fu, J., Liu, H., Lei, Y., Liu, Z., He, S., Jiang, X., Ren, D., Dong, E., et al. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1995597
Metadata
- Authors
- Faissner, A., Pyka, M., Geissler, M., Sobik, T., Frischknecht, R., Gundelfinger, E. D., & Seidenbecher, C.
- Affiliations
- Ruhr University Bochum (DE)
- Leibniz Institute for Neurobiology (DE)
- Venue
- Brain Research Reviews
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 63
- Issue
- 1-2
- Pages
- 26-38
- ISSN
- 0165-0173 (ISSN-L)
- OpenAlex
- W2085339091
- Cited by
- 207
- References
- 144
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 12 · 2021: 13 · 2020: 11 · 2019: 14 · 2018: 18 · 2017: 13 · 2016: 15 · 2015: 15 · 2014: 21 · 2013: 9 · 2012: 20
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Brain Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- astrocytes, synaptogenesis, synapse maturation, perineuronal nets, tripartite synapse, synaptic plasticity, synaptic pruning, tenascin, chondroitin sulfate proteoglycans, lecticans, glycoproteins, neuron-glia interactions
- MeSH terms
- Animals, Astrocytes, Extracellular Matrix, Neurons, Synapses
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
