Primary Hippocampal Neurons, Which Lack Four Crucial Extracellular Matrix Molecules, Display Abnormalities of Synaptic Structure and Function and Severe Deficits in Perineuronal Net Formation
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The extracellular matrix (ECM) of the brain plays crucial roles during the development, maturation, and regeneration of the CNS. In a subpopulation of neurons, the ECM condenses to superstructures called perineuronal nets (PNNs) that surround synapses. Camillo Golgi described PNNs a century ago, yet their biological functions remain elusive. Here, we studied a mouse mutant that lacks four ECM components highly enriched in the developing brain: the glycoproteins tenascin-C and tenascin-R and the chondroitin sulfate proteoglycans brevican and neurocan. Primary embryonic hippocampal neurons and astrocytes were cultivated using a cell insert system that allows for co-culture of distinct cell populations in the absence of direct membrane contacts. The wild-type and knock-out cells were combined in the four possible permutations. Using this approach, neurons cultivated in the presence of mutant astrocytes displayed a transient increase of synapses after 2 weeks. However, after a period of 3 weeks or longer, synapse formation and stabilization were compromised when either neuron or astrocyte cell populations or both were of mutant origin. The development of PNN structures was observed, but their size was substantially reduced on knock-out neurons. The synaptic activity of both wild-type and knock-out neurons was monitored using whole-cell patch clamping. The salient observation was a reduced frequency of IPSCs and EPSCs, whereas the amplitudes were not modified. Remarkably, the knock-out neuron phenotypes could not be rescued by wild-type astrocytes. We conclude that the elimination of four ECM genes compromises neuronal function.
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Genetic ablation of PNN structural components and consequent loss of neuronal PNN integrity can induce loss of synapses and impaired synaptic colocalization/expression of neurotransmitter receptor subunits, potentially manifesting as deficits in synaptic plasticity.
“This may be due in part to the degradation of the PNNs in which synapses are embedded, as the genetic ablation of one or more PNN structural components and consequent loss of neuronal PNN integrity can induce the loss of synapses [28, 80] and impaired synaptic colocalization/expression of neurotransmitter receptor subunits [29], potentially manifesting as deficits in synaptic plasticity (e.g. LTP)”
From Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain (2020) · cites this paper as [80]
PNNs are constructed autonomously by neurons.
“PNNs are autonomously constructed by neurons (Miyata et al. , 2005; Geissler et al. , 2013; Fowke et al. , 2017)”
From Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease (2020) · cites this paper as Geissler et al. , 2013
A previous study from the authors' laboratory found diminished PNNs and altered expression of synaptic proteins accompanied by decreased frequency of mEPSCs and mIPSCs after 14 and 21 DIV in hippocampal neurons of the quadruple knockout mouse in vitro.
“In a previous study our laboratory investigated hippocampal neurons of the quadruple knockout mouse in vitro and found diminished PNNs and an altered expression of synaptic proteins that were accompanied by a decreased frequency of mEPSCs and mIPSCs after 14 and 21 DIV29.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [29]
The in vivo PNN formation results fit with the in vitro findings, both demonstrating a diminished PNN formation in the postnatal quadruple knockout mouse.
“The results found for the in vivo PNN formation fit perfectly with the in vitro findings29, both demonstrating a diminished PNN formation in the postnatal quadruple knockout mouse.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [29]
Loss of TnC, TnR, brevican and neurocan in hippocampal quadruple knockout neurons in an in vitro co-culture system resulted in a significant increase of synaptic density within 14 DIV that transited to a decremented synapse number after 21 DIV.
“The loss of TnC, TnR, brevican and neurocan resulted in a significant increase of synaptic density within 14 DIV that transited to a decremented synapse number after 21 DIV.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [29]
Neurons coated with PNNs were characterized by an attenuated synapse number after both 14 and 21 DIV.
“Neurons coated with PNNs were characterized by an attenuated synapse number after both 14 and 21 DIV29.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [29]
Hippocampal neurons lacking neurocan, brevican, tenascin-R, and tenascin-C display rudimentary perineuronal nets and reduced synapse number, suggesting that PNNs are important for synapse formation or stabilization.
“In this model hippocampal neurons lacking neurocan, brevican, TN-R and TN-C display rudimentary PNNs and reduced synapse number, suggesting that PNNs are important for synapse formation/stabilization (Geissler et al., 2013).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Geissler et al., 2013
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Cites
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129 · see citing works
Tripartite synapses: astrocytes process and control synaptic information
Perea, G., Navarrete, M., & Araque, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.001 · Cited by 1,820 · see citing works
CNS synaptogenesis promoted by glia-derived cholesterol
Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711 · see citing works
Kaech, S., & Banker, G. A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.356 · Cited by 1,705 · see citing works
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688 · see citing works
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679 · see citing works
Glia: listening and talking to the synapse
Haydon, P. G. (2001) · Nature reviews. Neuroscience · doi:10.1038/35058528 · Cited by 1,410 · see citing works
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344 · see citing works
Culturing hippocampal neurons.
Tanaka, H. (2002) · Folia Pharmacologica Japonica · doi:10.1254/fpj.119.163 · Cited by 1,141 · see citing works
Sommer, I., & Schachner, M. (1981) · Developmental Biology · doi:10.1016/0012-1606(81)90477-2 · Cited by 1,136 · see citing works
Perineuronal Nets Protect Fear Memories from Erasure
Gogolla, N., Caroni, P., Lüthi, A., & Herry, C. (2009) · Science · doi:10.1126/science.1174146 · Cited by 760 · see citing works
Galtrey, C. M., & Fawcett, J. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.006 · Cited by 575 · see citing works
The dual role of the extracellular matrix in synaptic plasticity and homeostasis
Dityatev, A., Schachner, M., & Sonderegger, P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2898 · Cited by 559 · see citing works
Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity
Frischknecht, R., Heine, M., Perrais, D., Seidenbecher, C. I., Choquet, D., & Gundelfinger, E. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2338 · Cited by 554 · see citing works
Activity-dependent structural and functional plasticity of astrocyte-neuron interactions
Theodosis, D. T., Poulain, D. A., & Oliet, S. H. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00036.2007 · Cited by 531 · see citing works
Local Ca2+ detection and modulation of synaptic release by astrocytes
Di Castro, M. A., Chuquet, J., Liaudet, N., Bhaukaurally, K., Santello, M., Bouvier, D., Tiret, P., & Volterra, A. (2011) · Nature Neuroscience · doi:10.1038/nn.2929 · Cited by 529 · see citing works
Perineuronal nets: past and present
Celio, M. R., Spreafico, R., De Biasi, S., & Vitellaro-Zuccarello, L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01298-3 · Cited by 497 · see citing works
Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
Carulli, D., Pizzorusso, T., Kwok, J. C. F., Putignano, E., Poli, A., Forostyak, S., Andrews, M. R., Deepa, S. S., Glant, T. T., & Fawcett, J. W. (2010) · Brain · doi:10.1093/brain/awq145 · Cited by 495 · see citing works
Neurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes
Asher, R. A., Morgenstern, D. A., Fidler, P. S., Adcock, K. H., Oohira, A., Braistead, J. E., Levine, J. M., Margolis, R. U., ROGERS, J. H., & Fawcett, J. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02427.2000 · Cited by 482 · see citing works
Dieck, S., Sanmartí-Vila, L., Langnaese, K., Richter, K., Kindler, S., Soyke, A., Wex, H., Smalla, K.-H., Kämpf, U., Fränzer, J.-T., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.2.499 · Cited by 482 · see citing works
Experimental observations on the development of polarity by hippocampal neurons in culture.
Goslin, K., & Banker, G. A. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.4.1507 · Cited by 416 · see citing works
Extracellular matrix and perineuronal nets in CNS repair
Kwok, J. C. F., Dick, G., Wang, D., & Fawcett, J. W. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20974 · Cited by 395 · see citing works
J1/tenascin is a repulsive substrate for central nervous system neurons
Faissner, A., & Kruse, J. (1990) · Neuron · doi:10.1016/0896-6273(90)90217-4 · Cited by 378 · see citing works
Self-citationRole for glia in synaptogenesis
Ullian, E. M., Christopherson, K. S., & Barres, B. A. (2004) · Glia · doi:10.1002/glia.20082 · Cited by 370 · see citing works
Composition of Perineuronal Net Extracellular Matrix in Rat Brain
Deepa, S. S., Carulli, D., Galtrey, C., Rhodes, K., Fukuda, J., Mikami, T., Sugahara, K., & Fawcett, J. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600544200 · Cited by 367 · see citing works
Dityatev, A., Brückner, G., Dityateva, G., Grosche, J., Kleene, R., & Schachner, M. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20361 · Cited by 365 · see citing works
Carulli, D., Rhodes, K. E., Brown, D. J., Bonnert, T. P., Pollack, S. J., Oliver, K., Strata, P., & Fawcett, J. W. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20822 · Cited by 341 · see citing works
Development of Excitatory Circuitry in the Hippocampus
Hsia, A. Y., Malenka, R. C., & Nicoll, R. A. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.4.2013 · Cited by 279 · see citing works
Expression of tenascin in the developing and adult cerebellar cortex
Bartsch, S., Bartsch, U., Dörries, U., Faissner, A., Weller, A., Ekblom, P., & Schachner, M. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00736.1992 · Cited by 271 · see citing works
Self-citationNeurofascin assembles a specialized extracellular matrix at the axon initial segment
Hedstrom, K. L., Xu, X., Ogawa, Y., Frischknecht, R., Seidenbecher, C. I., Shrager, P., & Rasband, M. N. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705119 · Cited by 268 · see citing works
Brakebusch, C., Seidenbecher, C. I., Asztely, F., Rauch, U., Matthies, H., Meyer, H., Krug, M., Böckers, T. M., Zhou, X., Kreutz, M. R., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7417-7427.2002 · Cited by 264 · see citing works
Self-citation[Chondroitin sulfate proteoglycans in neural development and regeneration].
Gu, W.-L., & Lu, P. (2007) · PubMed · Cited by 255 · see citing works
Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
Ippolito, D. M., & Eroğlu, Ç. (2010) · Journal of Visualized Experiments · doi:10.3791/2270 · Cited by 254 · see citing works
Bukalo, O., Schachner, M., & Dityatev, A. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00082-3 · Cited by 236 · see citing works
Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain
Saghatelyan, A., de Chevigny, A., Schachner, M., & Lledo, P. (2004) · Nature Neuroscience · doi:10.1038/nn1211 · Cited by 229 · see citing works
Dityatev, A. E., Seidenbecher, C. I., & Schachner, M. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.08.003 · Cited by 229 · see citing works
New roles for astrocytes: Regulation of CNS synaptogenesis
Ślęzak, M., & Pfrieger, F. W. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.005 · Cited by 224 · see citing works
Kochlamazashvili, G., Henneberger, C., Bukalo, O., Dvoretskova, E., Senkov, O., Lievens, P. M.-J., Westenbroek, R., Engel, A. K., Catterall, W. A., Rusakov, D. A., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.030 · Cited by 215 · see citing works
Chondroitin sulfate proteoglycans in neural development and regeneration
Laabs, T. L., Carulli, D., Geller, H. M., & Fawcett, J. W. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.01.014 · Cited by 211 · see citing works
Perineuronal net formation and structure in aggrecan knockout mice
Giamanco, K. A., Morawski, M., & Matthews, R. T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.032 · Cited by 207 · see citing works
Wang, D., Ichiyama, R. M., Zhao, R., Andrews, M. R., & Fawcett, J. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0983-11.2011 · Cited by 207 · see citing works
Faissner, A., Pyka, M., Geissler, M., Sobik, T., Frischknecht, R., Gundelfinger, E. D., & Seidenbecher, C. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.01.001 · Cited by 207 · see citing works
Self-citationSaghatelyan, A. K., Dityatev, A., Schmidt, S., Schuster, T., Bartsch, U., & Schachner, M. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0922 · Cited by 207 · see citing works
Modulation of Perineuronal Nets and Parvalbumin with Developmental Song Learning
Balmer, T. S., Carels, V. M., Frisch, J. L., & Nick, T. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2974-09.2009 · Cited by 181 · see citing works
Fuss, B., Wintergerst, E. S., Bartsch, U., & Schachner, M. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.5.1237 · Cited by 177 · see citing works
Evers, M. R., Salmen, B., Bukalo, O., Rollenhagen, A., Bösl, M. R., Morellini, F., Bartsch, U., Dityatev, A., & Schachner, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07177.2002 · Cited by 172 · see citing works
Kwok, J. C. F., Carulli, D., & Fawcett, J. W. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06878.x · Cited by 170 · see citing works
Haas, C. A., Rauch, U., Thon, N., Merten, T., & Deller, T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09953.1999 · Cited by 151 · see citing works
Self-citationSeidenbecher, C. I., Richter, K., Rauch, U., Fässler, R., Garner, C. C., & Gundelfinger, E. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27206 · Cited by 149 · see citing works
Self-citationProteomic Analysis of Astrocytic Secretion in the Mouse
Lafon‐Cazal, M., Adjali, O., Galéotti, N., Poncet, J., Jouin, P., Homburger, V., Bockaert, J., & Marin, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211980200 · Cited by 143 · see citing works
Rathjen, F. G., Wolff, M., & Chiquet‐Ehrismann, R. (1991) · Development · doi:10.1242/dev.113.1.151 · Cited by 140 · see citing works
Giamanco, K. A., & Matthews, R. T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.055 · Cited by 138 · see citing works
Structural and Functional Aberrations in the Cerebral Cortex of Tenascin-C Deficient Mice
Irintchev, A., Rollenhagen, A., Troncoso, E., Kiss, J. Z., & Schachner, M. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhh195 · Cited by 137 · see citing works
Aggrecan: Beyond cartilage and into the brain
Morawski, M., Brückner, G., Arendt, T., & Matthews, R. T. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.01.010 · Cited by 136 · see citing works
Converting juvenile into adult plasticity: a role for the brain's extracellular matrix
Gundelfinger, E. D., Frischknecht, R., Choquet, D., & Heine, M. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07253.x · Cited by 136 · see citing works
Weston, M. C., Nehring, R. B., Wojcik, S. M., & Rosenmund, C. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.002 · Cited by 134 · see citing works
Pyka, M., Wetzel, C., Aguado, A., Geissler, M., Hatt, H., & Faissner, A. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07690.x · Cited by 131 · see citing works
Self-citationJohn, N., Krügel, H., Frischknecht, R., Smalla, K.-H., Schultz, C., Kreutz, M. R., Gundelfinger, E. D., & Seidenbecher, C. I. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.01.011 · Cited by 122 · cited 3× · see citing works
“1) confirms earlier reports that highlighted the localization at the axon hillock (John et al., 2006; Hedstrom et al., 2007).”
BackgroundResultSaghatelyan, A., Gorissen, S., Albert, M., Hertlein, B., Schachner, M., & Dityatev, A. E. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00216.x · Cited by 117 · see citing works
Neurons Produce a Neuronal Cell Surface-Associated Chondroitin Sulfate Proteoglycan
Lander, C., Zhang, H., & Hockfield, S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00174.1998 · Cited by 107 · see citing works
Morellini, F., Sivukhina, E., Stoenica, L., Oulianova, E., Bukalo, O., Jakovcevski, I., Dityatev, A., Irintchev, A., & Schachner, M. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq017 · Cited by 104 · see citing works
Zhao, R., Muir, E. M., Alves, J. N., Rickman, H. M., Allan, A. Y., Kwok, J. C. F., Roet, K. C. D., Verhaagen, J., Schneider, B. L., Bensadoun, J., et al. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.08.003 · Cited by 94 · see citing works
Artificial Astrocytes Improve Neural Network Performance
Porto-Pazos, A. B., Veiguela, N., Mesejo, P., Navarrete, M., Alvarellos, A., Ibáñez, O., Pazos, A., & Araque, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019109 · Cited by 89 · see citing works
Extracellular matrix alterations in brains lacking four of its components
Rauch, U., Zhou, X.-H., & Roos, G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.026 · Cited by 88 · see citing works
Self-citationNeurotrophin signaling among neurons and glia during formation of tripartite synapses
Elmariah, S. B., Hughes, E. G., Oh, E. J., & Balice‐Gordon, R. J. (2004) · Neuron Glia Biology · doi:10.1017/s1740925x05000189 · Cited by 85 · see citing works
Hippocampal Metaplasticity Induced by Deficiency in the Extracellular Matrix Glycoprotein Tenascin-R
Bukalo, O., Schachner, M., & Dityatev, A. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1022-07.2007 · Cited by 80 · see citing works
Karus, M., Denecke, B., ffrench‐Constant, C., Wiese, S., & Faissner, A. (2011) · Development · doi:10.1242/dev.067413 · Cited by 80 · see citing works
Self-citationCross-talk between neurons and glia: highlights on soluble factors
Gomes, F. C. A., Spohr, T., Martinez, R., & Moura‐Neto, V. (2001) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2001000500008 · Cited by 79 · see citing works
Matsui, F., Nishizuka, M., Yasuda, Y., Aono, S., Watanabe, E., & Oohira, A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00009-2 · Cited by 78 · see citing works
Susarla, B. T. S., Laing, E. D., Yu, P., Katagiri, Y., Geller, H. M., & Symes, A. J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07470.x · Cited by 78 · see citing works
Zhang, Y., Anderson, P. N., Campbell, G., Mohajeri, H. M., Schachner, M., & Lieberman, A. R. (1995) · Journal of Neurocytology · doi:10.1007/bf01257374 · Cited by 71 · see citing works
Nikonenko, A., Schmidt, S., Skibo, G., Brückner, G., & Schachner, M. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10537 · Cited by 69 · see citing works
Training and anti-CSPG combination therapy for spinal cord injury
García‐Alías, G., & Fawcett, J. W. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.009 · Cited by 67 · see citing works
Casting a net on dendritic spines: The extracellular matrix and its receptors
Dansie, L. E., & Ethell, I. M. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20963 · Cited by 66 · see citing works
Freeing the Brain from the Perineuronal Net
Fox, K. D., & Caterson, B. (2002) · Science · doi:10.1126/science.1079224 · Cited by 57 · see citing works
Transient increase of tenascin-C in immature hippocampus: astroglial and neuronal expression
Ferhat, L., Chevassus-au-Louis, N., Jorquera, I., Niquet, J., Khrestchatisky, M., Ben‐Ari, Y., & Represa, A. (1996) · Journal of Neurocytology · doi:10.1007/bf02284785 · Cited by 52 · see citing works
Wintergerst, E. S., Faissner, A., & Celio, M. R. (1996) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(96)00011-1 · Cited by 46 · see citing works
Self-citationPyka, M., Busse, C., Seidenbecher, C. I., Gundelfinger, E. D., & Faissner, A. (2010) · Synapse · doi:10.1002/syn.20816 · Cited by 41 · see citing works
Self-citationSeizures induce tenascin-C mRNA expression in neurons
Ferhat, L., Chevassus-au-Louis, N., Khrestchatisky, M., Ben‐Ari, Y., & Represa, A. (1996) · Journal of Neurocytology · doi:10.1007/bf02284821 · Cited by 40 · see citing works
Geißler, M., & Faissner, A. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.11.030 · Cited by 36 · see citing works
Self-citationTenascin-C stimulates contactin-dependent neurite outgrowth via activation of phospholipase C
Michele, M., & Faissner, A. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.04.004 · Cited by 28 · see citing works
Self-citationCybulska-Kłosowicz, A., Zakrzewska, R., Pyza, E., Kossut, M. M., & Schachner, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03605.x · Cited by 21 · see citing works
Mahler, M., Ferhat, L., Gillian, A. M., Ben-Ari, Y., & Represa, A. (1996) · Cell Communication & Adhesion · doi:10.3109/15419069609014221 · Cited by 12 · see citing works
Novel conserved oligodendrocyte surface epitope identified by monoclonal antibody 4860
Czopka, T., Hennen, E., von Holst, A., & Faissner, A. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0868-9 · Cited by 11 · see citing works
Self-citationPostnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R
Br�ckner, G., Grosche, J., Schmidt, S., H�rtig, W., Margolis, R. U., Delpech, B., Seidenbecher, C. I., Czaniera, R., & Schachner, M. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001225)428:4
Meyer-Puttlitz (1996) · doi:10.1002/(sici)1096-9861(19960226)366:1
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The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
Fawcett, J. W., Oohashi, T., & Pizzorusso, T. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0196-3 · Cited by 589 · see citing works
Bioprinting: From Tissue and Organ Development to in Vitro Models
Mota, C., Camarero‐Espinosa, S., Baker, M., Wieringa, P., & Moroni, L. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00789 · Cited by 308 · see citing works
Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain
Crapser, J. D., Spangenberg, E. E., Barahona, R. A., Arreola, M. A., Hohsfield, L. A., & Green, K. N. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102919 · Cited by 280 · see citing works
Crosstalk between glia, extracellular matrix and neurons
Song, I., & Dityatev, A. E. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.03.003 · Cited by 263 · see citing works
Microglia as hackers of the matrix: sculpting synapses and the extracellular space
Crapser, J. D., Arreola, M. A., Tsourmas, K. I., & Green, K. N. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00751-3 · Cited by 178 · see citing works
Miyata, S., & Kitagawa, H. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.010 · Cited by 171 · see citing works
Crapser, J. D., Ochaba, J., Soni, N., Reidling, J. C., Thompson, L. M., & Green, K. N. (2020) · Brain · doi:10.1093/brain/awz363 · Cited by 157 · see citing works
The role of astrocyte‐mediated plasticity in neural circuit development and function
Perez-Catalan, N. A., Doe, C. Q., & Ackerman, S. D. (2021) · Neural Development · doi:10.1186/s13064-020-00151-9 · Cited by 137 · see citing works
Riga, D., Kramvis, I., Koskinen, M. K., van Bokhoven, P., van der Harst, J. E., Heistek, T. S., Jaap Timmerman, A., van Nierop, P., van der Schors, R. C., Pieneman, A. W., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai8753 · Cited by 128 · see citing works
Wingert, J. C., & Sorg, B. A. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.673210 · Cited by 129 · see citing works
Kim, S. Y., Senatorov, V. V., Morrissey, C. S., Lippmann, K., Vazquez, O. N., Milikovsky, D. Z., Gu, F., Parada, I., Prince, D. A., Becker, A. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07394-3 · Cited by 136 · see citing works
Dzyubenko, E., Gottschling, C., & Faissner, A. (2016) · Neural Plasticity · doi:10.1155/2016/5214961 · Cited by 134 · see citing works
Self-citationOohashi, T., Edamatsu, M., Bekku, Y., & Carulli, D. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.09.010 · Cited by 131 · see citing works
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Carulli, D., & Verhaagen, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052434 · Cited by 123 · see citing works
Gottschling, C., Wegrzyn, D., Denecke, B., & Faissner, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-50404-9 · Cited by 111 · see citing works
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Smith, P. D., Coulson‐Thomas, V. J., Foscarin, S., Kwok, J. C. F., & Fawcett, J. W. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.004 · Cited by 112 · see citing works
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Carulli, D., Broersen, R., de Winter, F., Muir, E. M., Mešković, M., de Waal, M., de Vries, S., Boele, H.-J., Canto, C. B., De Zeeuw, C. I., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916163117 · Cited by 110 · see citing works
Cell adhesion and matricellular support by astrocytes of the tripartite synapse
Hillen, A. E. J., Burbach, J. P. H., & Hol, E. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.02.002 · Cited by 108 · see citing works
Tewari, B. P., Chaunsali, L., Prim, C. E., & Sontheimer, H. W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1022754 · Cited by 107 · see citing works
Avram, S., Shaposhnikov, S. A., Buiu, C., & Mernea, M. (2014) · BioMed Research International · doi:10.1155/2014/642798 · Cited by 106 · see citing works
Quraishe, S., Forbes, L. H., & Andrews, M. R. (2018) · Neural Plasticity · doi:10.1155/2018/2952386 · Cited by 105 · see citing works
Luca, C. D., Colangelo, A. M., Virtuoso, A., Alberghina, L., & Papa, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041539 · Cited by 104 · see citing works
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Ohtake, Y., & Li, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.08.064 · Cited by 102 · see citing works
Dzyubenko, E., Rozenberg, A., Hermann, D. M., & Faissner, A. (2016) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2016.09.001 · Cited by 98 · see citing works
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Arreola, M. A., Soni, N., Crapser, J. D., Hohsfield, L. A., Elmore, M. R. P., Matheos, D. P., Wood, M. A., Swarup, V., Mortazavi, A., & Green, K. N. (2021) · Science Advances · doi:10.1126/sciadv.abg1601 · Cited by 89 · see citing works
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Duncan, B. W., Murphy, K. E., & Maness, P. F. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.625340 · Cited by 84 · see citing works
Human neuronal maturation comes of age: cellular mechanisms and species differences
Wallace, J. L., & Pollen, A. A. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00760-3 · Cited by 82 · see citing works
Marcette, J., Chen, J. J., & Nonet, M. L. (2014) · eLife · doi:10.7554/elife.01637 · Cited by 79 · see citing works
Extracellular Matrix in Neural Plasticity and Regeneration
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Lian, H., & Zheng, H. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13424 · Cited by 75 · see citing works
Blosa, M., Sonntag, M., Jäger, C., Weigel, S., Seeger, J., Frischknecht, R., Seidenbecher, C. I., Matthews, R. T., Arendt, T., Rübsamen, R., et al. (2015) · The Journal of Physiology · doi:10.1113/jp270849 · Cited by 74 · see citing works
Yamada, J., & Jinno, S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.061 · Cited by 71 · see citing works
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Bres, E. E., & Faissner, A. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00031 · Cited by 67 · see citing works
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Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R
Dankovich, T. M., Kaushik, R., Olsthoorn, L. H. M., Petersen, G. C., Giro, P. E., Kluever, V., Agüi‐Gonzalez, P., Grewe, K., Bao, G., Beuermann, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27462-7 · Cited by 63 · see citing works
Modulation of semaphorin3A in perineuronal nets during structural plasticity in the adult cerebellum
Carulli, D., Foscarin, S., Faralli, A., Pajaj, E., & Rossi, F. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.08.003 · Cited by 59 · see citing works
Apóstolo, N., Smukowski, S. N., Vanderlinden, J., Condomitti, G., Rybakin, V., ten Bos, J., Trobiani, L., Portegies, S., Vennekens, K. M., Gounko, N. V., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18956-x · Cited by 61 · see citing works
Influence of the extracellular matrix on endogenous and transplanted stem cells after brain damage
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Self-citationRoll, L., & Faissner, A. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.09.012 · Cited by 54 · see citing works
Self-citationPerineuronal Nets: Subtle Structures with Large Implications
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Role of immune responses for extracellular matrix remodeling in the ischemic brain
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Self-citationIn vitro models for neurotoxicology research
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Hyaluronan synthesis by developing cortical neurons in vitro
Fowke, T. M., Karunasinghe, R. N., Bai, J.-Z., Jordan, S., Gunn, A. J., & Dean, J. M. (2017) · Scientific Reports · doi:10.1038/srep44135 · Cited by 47 · see citing works
A potential role for glia‐derived extracellular matrix remodeling in postinjury epilepsy
Kim, S. Y., Porter, B. E., Friedman, A., & Kaufer, D. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23758 · Cited by 47 · see citing works
Schulte, C., Ripamonti, M., Maffioli, E., Cappelluti, M. A., Nonnis, S., Puricelli, L., Lamanna, J., Piazzoni, C., Podestà, A., Lenardi, C., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00267 · Cited by 44 · see citing works
Diverse roles for glycosaminoglycans in neural patterning
Saied‐Santiago, K., & Bülow, H. E. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24555 · Cited by 47 · see citing works
Neural ECM in laminar organization and connectivity development in healthy and diseased human brain
Milošević, N. J., Judáš, M., Aronica, E., & Kostović, I. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63486-3.00007-4 · Cited by 43 · see citing works
Blacktop, J. M., Todd, R. P., & Sorg, B. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.03.018 · Cited by 43 · see citing works
Heikkinen, A., Pihlajaniemi, T., Faissner, A., & Yuzaki, M. (2014) · Progress in Brain Research · doi:10.1016/b978-0-444-63486-3.00002-5 · Cited by 42 · see citing works
Self-citationFine structure analysis of perineuronal nets in the ketamine model of schizophrenia
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Perineuronal Net Protein Neurocan Inhibits NCAM/EphA3 Repellent Signaling in GABAergic Interneurons
Sullivan, C. S., Gotthard, I., Wyatt, E. V., Bongu, S., Mohan, V., Weinberg, R. J., & Maness, P. F. (2018) · Scientific Reports · doi:10.1038/s41598-018-24272-8 · Cited by 37 · see citing works
AbouElhassan, K. M., Sarhan, H. A., Hussein, A. K., Taye, A., Ahmed, Y. M., & Safwat, M. A. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s381353 · Cited by 40 · see citing works
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Duncan, J. A., Foster, R., & Kwok, J. C. F. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14672 · Cited by 37 · see citing works
Inhibitory control in neuronal networks relies on the extracellular matrix integrity
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Self-citationKaretko, M., Skangiel-Kramska, J., & Nowicka, D. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.049 · Cited by 37 · see citing works
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Self-citationFrom molecules to behavior: Implications for perineuronal net remodeling in learning and memory
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The role of extracellular matrix in spinal cord development
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Abedsaeidi, M., Hojjati, F., Tavassoli, A., & Sahebkar, A. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230404124229 · Cited by 29 · see citing works
Yang, X. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0117 · Cited by 29 · see citing works
Glia activation and its role in oxidative stress
Ogundele, O. M., Omoaghe, A. O., Ajonijebu, D. C., Ojo, A. A., Fabiyi-Edebor, T. D., Olajide, O. J., Falode, D. T., & Adeniyi, P. A. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9446-7 · Cited by 28 · see citing works
Ueno, H., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Matsumoto, Y., Okamoto, M., & Ishihara, T. (2018) · IBRO Reports · doi:10.1016/j.ibror.2018.11.006 · Cited by 26 · see citing works
NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression
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Jansen, S., Gottschling, C., Faissner, A., & Manahan‐Vaughan, D. (2017) · Hippocampus · doi:10.1002/hipo.22742 · Cited by 26 · see citing works
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Li, X., Wu, X., Lu, T., Kuang, C., Si, Y., Zheng, W., Li, Z., & Xue, Y.-X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063412 · Cited by 25 · see citing works
Quattromani, M. J., Hakon, J., Rauch, U., Bauer, A. Q., & Wieloch, T. W. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.01.011 · Cited by 25 · see citing works
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Balsara, R. D., Dang, A. T., Donahue, D. L., Snow, T., & Castellino, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122840 · Cited by 23 · see citing works
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Briones, B. A., Pisano, T. J., Pitcher, M. N., Haye, A. E., Diethorn, E. J., Engel, E. A., Cameron, H. A., & Gould, E. (2021) · Hippocampus · doi:10.1002/hipo.23296 · Cited by 19 · see citing works
Illa, M., Brito, V., Plà, L., Eixarch, E., Arbat‐Plana, A., Batallé, D., Muñoz‐Moreno, E., Crispi, F., Udina, E., Figueras, F., et al. (2017) · Fetal Diagnosis and Therapy · doi:10.1159/000481171 · Cited by 16 · see citing works
Carbohydrate based biomaterials for neural interface applications
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Woo, A. M., & Sontheimer, H. W. (2023) · Frontiers in Molecular Medicine · doi:10.3389/fmmed.2023.1198021 · Cited by 15 · see citing works
Spatial patterns and cell surface clusters in perineuronal nets
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Reorganization of the Brain Extracellular Matrix in Hippocampal Sclerosis
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Wegrzyn, D., Manitz, M. P., Kostka, M., Freund, N., Juckel, G., & Faissner, A. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14934 · Cited by 14 · see citing works
Self-citationHyaluronic Acid and Regenerative Medicine: New Insights into the Stroke Therapy
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Critical functions of extracellular matrix in brain metastasis seeding
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Gisabella, B., Babu, J., Valeri, J., Rexrode, L., & Pantazopoulos, H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.646678 · Cited by 13 · see citing works
González-Calvo, I., Cizeron, M., Bessereau, J., & Selimi, F. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.866444 · Cited by 11 · see citing works
Aberrant perineuronal nets alter spinal circuits, impair motor function, and increase plasticity
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Parallels between the extracellular matrix roles in developmental biology and cancer biology
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Disease-specific glycosaminoglycan patterns in the extracellular matrix of human lung and brain
Ennemoser, M., Pum, A., & Kungl, A. J. (2021) · Carbohydrate Research · doi:10.1016/j.carres.2021.108480 · Cited by 11 · see citing works
Fasulo, L., Brandi, R., Arisi, I., Regina, F. L., Berretta, N., Capsoni, S., D’Onofrio, M., & Cattaneo, A. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00020 · Cited by 10 · see citing works
Patel, D. C., Swift, N. A., Tewari, B. P., Browning, J. L., Prim, C. E., Chaunsali, L., Kimbrough, I. F., Olsen, M. L., & Sontheimer, H. W. (2023) · Brain · doi:10.1093/brain/awad430 · Cited by 9 · see citing works
Mueller-Buehl, C., Pakusch, J., Bader, V., Winklhofer, K. F., Mark, M. D., & Faissner, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-89580-2 · Cited by 9 · see citing works
Self-citationMolecular mechanisms mediating involvement of glial cells in brain plastic remodeling in epilepsy
Хаспеков, Л. Г., & Frumkina, L. E. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917030178 · Cited by 10 · see citing works
- Authors
- Geissler, M., Gottschling, C., Aguado, A., Rauch, U., Wetzel, C. H., Hatt, H., & Faissner, A.
- Affiliations
- Ruhr University Bochum (DE)
- Lund University (SE)
- University of Regensburg (DE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2013-05-01
- Volume
- 33
- Issue
- 18
- Pages
- 7742-7755
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6618965
- OpenAlex
- W2012448906
- Cited by
- 140
- References
- 86
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 13 · 2022: 12 · 2021: 15 · 2020: 18 · 2019: 10 · 2018: 11 · 2017: 16 · 2016: 7 · 2015: 8 · 2014: 11 · 2013: 3
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- perineuronal nets, extracellular matrix, hippocampal neurons, astrocytes, tenascin-C, tenascin-R, brevican, neurocan, chondroitin sulfate proteoglycans, synaptogenesis, synapse stabilization, inhibitory postsynaptic currents, excitatory postsynaptic currents, co-culture, embryonic neurons
- MeSH terms
- Animals, Astrocytes, Cell Count, Cells, Cultured, Embryo, Mammalian, Female, Hippocampus, Male, Mice, Inbred C57BL, Nerve Net, Neurons, Synapses, Extracellular Matrix Proteins, Mice, Knockout, Gene Expression Regulation, Developmental, Coculture Techniques, Tenascin, Excitatory Postsynaptic Potentials, Mice, Inhibitory Postsynaptic Potentials, Neurocan, Brevican
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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