The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans
Open accessAbstract
BACKGROUND The brain-derived neurotrophic factor (BDNF) gene is involved in mechanisms of synaptic plasticity in the adult brain. It has been demonstrated that BDNF also plays a significant role in shaping externally induced human brain plasticity. Plasticity induced in the human motor cortex by intermittent theta-burst stimulation (iTBS) was impaired in individuals expressing the Val66Met polymorphism. METHODS To explore whether this polymorphism is also important for other neuroplasticity-inducing tools in humans with modes of action differing from that of iTBS, namely, transcranial direct current (tDCS) and random noise stimulation (tRNS), we retrospectively analyzed the data of 64 subjects studied in our laboratory with regard to BDNF genotype. RESULTS Fifteen subjects with the Val66Met allele, 46 subjects with the Val66Val allele, and 3 Met66Met carriers were identified. The response of the Val66Met allele carriers to stimulation differed in two protocols compared with the response of Val66Val individuals. For iTBS (15 subjects, 5 heterozygotes), plasticity could be only induced in the Val66Val allele carriers. However, for facilitatory tDCS (24 subjects, 10 heterozygotes), as well as for inhibitory tDCS, (19 subjects, 8 heterozygotes), carriers of the Val66Met allele displayed enhanced plasticity, whereas for transcranial random noise stimulation (29 subjects, 8 heterozygotes), the difference between groups was not so pronounced. CONCLUSIONS BDNF polymorphism has a definite impact on plasticity in humans, which might differ according to the mechanism of plasticity induction. This impact of BDNF on plasticity should be taken into account for future studies, as well as having wider ranging implications for the treatment of neuropsychiatric disorders with transcranial stimulation tools, as it may predetermine their efficacy for the treatment of disease and rehabilitation.
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Cites
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Self-citationTheta Burst Stimulation of the Human Motor Cortex
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Transcranial direct current stimulation: State of the art 2008
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Self-citationSustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
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Self-citationBDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
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Cited by
Neuroplasticity Subserving Motor Skill Learning
Dayan, E., & Cohen, L. G. (2011) · Neuron · doi:10.1016/j.neuron.2011.10.008 · Cited by 1,408
Modarresi, F., Faghihi, M. A., Lopez-Toledano, M. A., Fatemi, R. P., Magistri, M., Brothers, S. P., van der Brug, M. P., & Wahlestedt, C. (2012) · Nature Biotechnology · doi:10.1038/nbt.2158 · Cited by 668
Ten years of theta burst stimulation in humans: Established knowledge, unknowns and prospects
Suppa, A., Huang, Y.-Z., Funke, K., Ridding, M. C., Cheeran, B., Di Lazzaro, V., Ziemann, U., & Rothwell, J. C. (2016) · Brain Stimulation · doi:10.1016/j.brs.2016.01.006 · Cited by 609
“[36] reported that LTP-like plasticity could only be induced in 10 Val66Val allele carriers but not in 5 Val66Met allele carriers with iTBS, but Li Voti et al.”
Noninvasive brain stimulation: from physiology to network dynamics and back
Dayan, E., Censor, N., Buch, E. R., Sandrini, M., & Cohen, L. G. (2013) · Nature Neuroscience · doi:10.1038/nn.3422 · Cited by 585
Transcranial direct current stimulation – update 2011
Nitsche, M. A., & Paulus, W. (2011) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2011-0618 · Cited by 544
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Metadata
- Authors
- Antal, A., Chaieb, L., Moliadze, V., Monte-Silva, K., Poreisz, C., Thirugnanasambandam, N., Nitsche, M. A., Shoukier, M., Ludwig, H., & Paulus, W.
- Venue
- Brain Stimulation
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 3
- Issue
- 4
- Pages
- 230-237
- ISSN
- 1876-4754 (ISSN-L)
- 1935-861X
- OpenAlex
- W2139662468
- Cited by
- 257
- References
- 39
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- green
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