Tractography-activation models applied to subcallosal cingulate deep brain stimulation
Open accessAbstract
Deep brain stimulation (DBS) of the subcallosal cingulate white matter (SCCWM) is an experimental therapy for major depressive disorder (MDD). The specific axonal pathways that mediate the anti-depressant effects of DBS remain unknown. Patient-specific tractography-activation models (TAMs) are a new tool to help identify pathways modulated by DBS. TAMs consist of four basic components: 1) anatomical and diffusion-weighted imaging data acquired on the patient; 2) probabilistic tractography from the brain region surrounding the implanted DBS electrode; 3) finite element models of the electric field generated by the patient-specific DBS parameter settings; and 4) application of the DBS electric field to multi-compartment cable models of axons, with trajectories defined by the tractography, to predict action potential generation in specific pathways. This study presents TAM predictions from DBS of the SCCWM in one MDD patient. Our findings suggest that small differences in electrode location can generate substantial differences in the directly activated pathways.
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Subcallosal cingulate stimulation affects pathways that connect with the orbitofrontal cortex.
“it is possible that the subcallosal cingulate stimulation affects pathways that connect with the OFC (Johansen-Berg et al., 2008; Lujan et al., 2013; Dunlop et al., 2017; Riva-Posse et al., 2018).”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Lujan et al., 2013
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- Authors
- Lujan, J. L., Chaturvedi, A., Choi, K. S., Holtzheimer, P. E., Gross, R. E., Mayberg, H. S., & McIntyre, C. C.
- Affiliations
- Cleveland Clinic (US)
- Georgia Institute of Technology (US)
- Dartmouth College (US)
- Emory University (US)
- Corresponding author
- McIntyre, Cameron C.
- Venue
- Brain stimulation
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 6
- Issue
- 5
- Pages
- 737-739
- ISSN
- 1876-4754 (ISSN-L)
- 1935-861X
- PMC
- PMC3772993
- OpenAlex
- W2123940881
- Cited by
- 101
- References
- 13
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 11 · 2019: 4 · 2018: 10 · 2017: 10 · 2016: 11 · 2015: 13 · 2014: 9 · 2013: 2
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain stimulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R01 NS059736)
- Dana Foundation
- Stanley Foundation
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, major depressive disorder, probabilistic tractography, action potential generation, electrode placement
- MeSH terms
- Brain Mapping, Major Depressive Disorder, Gyrus Cinguli, Humans, Models, Neurological, Finite Element Analysis, Deep Brain Stimulation, Diffusion Tensor Imaging
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