Effects of Subcallosal Cingulate Deep Brain Stimulation on Negative Self-bias in Patients With Treatment-resistant Depression
Open accessAbstract
Background The cognitive neuropsychological model states that antidepressant treatment alters emotional biases early in treatment, and after this initial change in emotional processing, environmental and social interactions allow for long-term/sustained changes in mood and behavior.Objective Changes in negative self-bias after chronic subcallosal cingulate (SCC) deep brain stimulation (DBS) were investigated with the hypothesis that treatment would lead to changes in emotional biases followed by changes in symptom severity.Methods Patients (N = 7) with treatment-resistant depression were assessed at three time points: pre-treatment; after one month stimulation; and after six months stimulation. The P1, P2, P3, and LPP (late positive potential) components of the event-related potential elicited by positive and negative trait adjectives were recorded in both a self-referential task and a general emotion recognition task.Results Results indicate that DBS reduced automatic attentional bias toward negative words early in treatment, as indexed by the P1 component, and controlled processing of negative words later in treatment, as indexed by the P3 component. Reduction in negative words endorsed as self-descriptive after six months DBS was associated with reduced depression severity after six months DBS. Change in emotional processing may be restricted to the self-referential task.Conclusions Together, these results suggest that the cognitive neuropsychological model, developed to explain the time-course of monoamine antidepressant treatment, may also be used as a framework to interpret the antidepressant effects of SCC DBS.
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DBS affects EEG components corresponding to a positive shift in emotional bias 1 and 6 months after electrodes were implanted, and EEG changes at month 6 negatively correlated with depression scores.
“Deep brain stimulation (DBS) (Benabid et al. 2009), an invasive neuromodulatory approach, was shown to affect EEG components corresponding to positive shift in emotional bias 1 and 6 month after electrodes were implanted; EEG changes measured at month 6 negatively correlated with depression scores (Hilimire et al. 2015).”
From Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment (2021) · cites this paper as Hilimire et al. 2015
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- Authors
- Hilimire, M. R., Mayberg, H. S., Holtzheimer, P. E., Broadway, J. M., Parks, N. A., DeVylder, J. E., & Corballis, P. M.
- Affiliations
- William & Mary (US)
- Emory University (US)
- Dartmouth College (US)
- University of California, Santa Barbara (US)
- University of Arkansas at Fayetteville (US)
- Columbia University (US)
- University of Auckland (NZ)
- Venue
- Brain Stimulation
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 8
- Issue
- 2
- Pages
- 185-191
- ISSN
- 1876-4754 (ISSN-L)
- 1935-861X
- PMC
- PMC4366934
- OpenAlex
- W2143594657
- Cited by
- 42
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 7
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain stimulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- W&M Publish (College of William & Mary) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Mental Health (K23MH077869)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- subcallosal cingulate, deep brain stimulation, treatment-resistant depression, attentional bias, event-related potentials, P1 component, P300, late positive potential, self-referential processing, emotion recognition, trait adjectives, depression severity
- MeSH terms
- Adult, Emotions, Evoked Potentials, Female, Gyrus Cinguli, Humans, Male, Psychomotor Performance, Prefrontal Cortex, Deep Brain Stimulation, Depressive Disorder, Treatment-Resistant
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