The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The role of CXC chemokines and their receptors in cancer
Open accessAbstract
Chemokines, or chemotactic cytokines, and their receptors have been discovered as essential and selective mediators in leukocyte migration to inflammatory sites and to secondary lymphoid organs. Besides their functions in the immune system, they also play a critical role in tumor initiation, promotion and progression. There are four subgroups of chemokines: CXC, CC, CX(3)C, and C chemokine ligands. The CXC or alpha subgroup is further subdivided in the ELR(+) and ELR(-) chemokines. Members that contain the ELR motif bind to CXC chemokine receptor 2 (CXCR2) and are angiogenic. In contrast, most of the CXC chemokines without ELR motif bind to CXCR3 and are angiostatic. An exception is the angiogenic ELR(-)CXC chemokine stromal cell-derived factor-1 (CXCL12/SDF-1), which binds to CXCR4 and CXCR7 and is implicated in tumor metastasis. This review is focusing on the role of CXC chemokines and their receptors in tumorigenesis, including angiogenesis, attraction of leukocytes to tumor sites and induction of tumor cell migration and homing in metastatic sites. Finally, their therapeutic use in cancer treatment is discussed.
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Citations
Cites
Cancer and the chemokine network
Balkwill, F. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1388 · Cited by 2,343
Interleukin-8 as a macrophage-derived mediator of angiogenesis
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The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis
Strieter, R. M., Polverini, P. J., Kunkel, S. L., Arenberg, D. A., Burdick, M. D., Kasper, J., Dzuiba, J., Van Damme, J., Walz, A., Marriott, D., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27348 · Cited by 1,222
Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL
Staller, P., Sulitkova, J., Lisztwan, J., Moch, H., Oakeley, E. J., & Krek, W. (2003) · Nature · doi:10.1038/nature01874 · Cited by 870
Tuning inflammation and immunity by chemokine sequestration: decoys and more
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Self-citation
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Cytokine and Chemokine Signals of T‐Cell Exclusion in Tumors
Zhang, Y., Guan, X.-Y., & Jiang, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594609 · Cited by 133
Support of Tumor Endothelial Cells by Chemokine Receptors
Salazar, N., & Zabel, B. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00147 · Cited by 72
Bone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis
Moridi, I., Mamillapalli, R., Cosar, E., Ersoy, G. S., & Taylor, H. S. (2017) · Reproductive Sciences · doi:10.1177/1933719116672587 · Cited by 59
Yin, X., Wang, Z., Wu, T., Ma, M., Zhang, Z., Chu, Z., Hu, Q., Ding, H., Han, X., Xu, J., et al. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-02172-3 · Cited by 54
Metadata
- Authors
- Vandercappellen, J., Van Damme, J., & Struyf, S.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 267
- Issue
- 2
- Pages
- 226-244
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W1993544268
- Cited by
- 643
- References
- 8
- FWCI
- 21.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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