Bone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis
Open accessAbstract
Endometriosis is an inflammatory gynecological disorder caused by the growth of endometrial tissue outside the uterus. Endometriosis produces chemokines, including CXCL12, that attract bone marrow cells to the lesions. In this study, we describe the expression, localization, and chemotactic activity of CXCL12 in endometriotic lesions. Biopsies were collected both from women with endometriosis undergoing laparoscopy and control endometrium from women without endometriosis. Expression of CXCl12 and CXCR4 messenger RNA was increased approximately 4- and 6-fold, respectively, in endometriosis compared to eutopic endometrium. Immunohistochemistry of lesions revealed that CXCR4 was expressed in the stroma and epithelium in both endometriosis and control eutopic endometrium. The level of CXCR4 protein expression was significantly higher in all cellular compartments of the endometriotic lesions compared to control endometrium. CXCL12 protein expression was also higher in endometriotic lesions and was greatest in the epithelial compartment. CXCL12 was increased more in the condition media of cultured endometriosis than in controls as measured by enzyme-linked immunosorbent assay. Transwell chamber migration was used to demonstrate 2-fold increased chemoattraction of mouse bone marrow stem cells toward CXCL12 in the endometriotic-conditioned medium compared with eutopic endometrium. Our results indicate that a preferential recruitment of stem cells to endometriosis can explain how endometriosis outcompetes eutopic endometrium in recruiting the limited supply of circulating stem cells. The CXCL12/CXCR4 signaling axis is a potential target for the treatment of endometriosis and its associated disorders.
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SDF-1 plays a critical role in recruiting bone marrow derived stem cells to endometrium and ectopic endometrium.
“Incidentally or not, SDF-1 plays a critical role in recruiting bone marrow derived stem cells (BMDSCs) to endometrium and ectopic endometrium [90,91].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [90]
Some mesenchymal/mesothelial cells of the peritoneal cavity, of mesothelial repair after surgery, and in endometrium and endometriosis are directly derived from bone marrow.
“Some of these mesenchymal/ mesothelial cells of the peritoneal cavity (48), of the mesothelial repair after surgery (126) and in endometrium and endometriosis (127-131) are directly derived from bone marrow.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [131]
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- Authors
- Moridi, I., Mamillapalli, R., Cosar, E., Ersoy, G. S., & Taylor, H. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Mamillapalli, Ramanaiah
- Venue
- Reproductive Sciences
- Published
- 2017-04
- Volume
- 24
- Issue
- 4
- Pages
- 526-533
- ISSN
- 1933-7191 (ISSN-L)
- 1933-7205
- PMC
- PMC5933203
- OpenAlex
- W2531909400
- Cited by
- 59
- References
- 62
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 12 · 2021: 5 · 2020: 12 · 2019: 2 · 2018: 9 · 2017: 5
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproductive Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NIH U54, HD052668, NIH U54 HD052668 and R01 HD076422, NIH U54 HD052668)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD052668, R01HD076422)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, CXCL12, CXCR4, bone marrow-derived stem cells, chemotaxis, stem cell recruitment, chemokines, eutopic endometrium, endometriotic lesions, stem cell migration, CXCL12/CXCR4 signaling
- MeSH terms
- Adult, Bone Marrow Cells, Chemotaxis, Endometriosis, Endometrium, Female, Humans, Stem Cells, Receptors, CXCR4, Chemokine CXCL12, Young Adult
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