Cited by 219MicroRNA in disease regulationCancer-related molecular mechanisms researchGlioma Diagnosis and Treatment

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MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G

Chen, Yang, Liu, Wei, Chao, Tengfei, Zhang, Yu, Yan, Xingqi, Gong, Yanhua, Qiang, Boqin, Yuan, Jiangang, Sun, Maosheng, Peng, Xiaozhong·2008·Cancer Letters

DOI 10.1016/j.canlet.2008.06.034

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Abstract

MicroRNAs have been linked to different cancer-related processes. The microRNA miR-21 appears to function as an anti-apoptosis factor in glioblastomas. However, the functional target genes of miR-21 are largely unknown in glioblastomas. In this study, bioinformatics analysis was used to identify miR-21 target sites in various genes. Luciferase activity assay showed that a number of genes involved in apoptosis, PDCD4, MTAP, and SOX5, carry putative miR-21 binding sites. Expression of PDCD4 protein correlates inversely with expression of miR-21 in a number of human glioblastoma cell lines such as T98G, A172, U87, and U251. Inhibition of miR-21 increases endogenous levels of PDCD4 in cell line T98G and over-expression miR-21 inhibits PDCD4-dependent apoptosis. Together, these results indicate that miR-21 expression plays a key role in regulating cellular processes in glioblastomas and may serve as a target for effective therapies.

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Authors: Chen, Y., Liu, W., Chao, T., Zhang, Y., Yan, X., Gong, Y., Qiang, B., Yuan, J., Sun, M., & Peng, X.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Sun, Maosheng
Peng, Xiaozhong
ORCID: Chen, Yang
Liu, Wei
Chao, Tengfei
Zhang, Yu
Gong, Yanhua
Peng, Xiaozhong
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2008-12
Volume: 272
Issue: 2
Pages: 197-205
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2008.06.034
OpenAlex: W2091108445
Cited by: 217
References: 26
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 10 · 2018: 7 · 2017: 13 · 2016: 10 · 2015: 17 · 2014: 24 · 2013: 19 · 2012: 20
FWCI: 8.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
Keywords: miR-21, PDCD4, glioblastoma, microRNA binding sites, apoptosis, MTAP, SOX5, T98G cells, tumor suppressor regulation, miRNA inhibitors
MeSH terms: Base Sequence, Brain Neoplasms, Glioblastoma, Humans, Blotting, Northern, Blotting, Western, Down-Regulation, Gene Expression Regulation, Neoplastic, RNA-Binding Proteins, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, In Situ Nick-End Labeling, MicroRNAs, Cell Line, Tumor, Apoptosis Regulatory Proteins

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MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G

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