Targeting miR-21 in glioma: a small RNA with big potential
Abstract
IMPORTANCE OF THE FIELD: Glioma therapies have produced relatively small improvements over the past decade, highlighting an important need to identify novel ways to target this disease. Targeted therapies against single activated protein kinases have proven effective in some cancers including gastrointestinal stromal cancer and colon cancer, but not yet in gliomas where multiple pathways and targets may be involved. MicroRNAs are emerging as key regulators of multiple pathways involved in cancer development and progression and may become the next targeted therapies in glioma. AREAS COVERED IN THIS REVIEW: This review covers the basics of microRNA biology and specifically focuses on the roles of miR-21 in glioma and its potential as target for glioma therapy. WHAT THE READER WILL GAIN: This review will provide the reader with an in depth understanding of how miR-21 functions in glioma. We also review the current state of studies designed to specifically target miR-21 as a potential future therapeutic. TAKE HOME MESSAGE: Identifying novel targets for the treatment of glioma is critical for advancing the current state of the field. MicroRNAs provide a novel target; and in glioma, targeting miR-21 may have broad consequences for the tumor that make it an attractive potential therapeutic.
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miR-21 is widely expressed in mammalian cells, is located on chromosome 17q23.2 in humans, and its upregulation is associated with various types of solid tumors.
“miR-21 is a widespread expression of miRNA in mammalian cells located on chromosome 17q23.2 in humans, whose upregulation is associated with various types of solid tumors29–31.”
From Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway (2017) · cites this paper as [30]
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- Authors
- Moore, L. M., & Zhang, W.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- ORCID
- Zhang, Wei
- Venue
- Expert Opinion on Therapeutic Targets
- Publisher
- Informa Healthcare
- Published
- 2010-10-14
- Volume
- 14
- Issue
- 11
- Pages
- 1247-1257
- ISSN
- 1472-8222 (ISSN-L)
- 1744-7631
- OpenAlex
- W2030842519
- Cited by
- 51
- References
- 70
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 7 · 2015: 2 · 2014: 4 · 2013: 5 · 2012: 8
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Therapeutic Targets (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- miR-21, glioma, microRNA, miRNA-based therapy, targeted cancer therapy, tumor suppressor microRNA, glioma progression
- MeSH terms
- Animals, Antineoplastic Agents, Glioma, Humans, Drug Design, Oligonucleotides, Antisense, MicroRNAs
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