Butein induces G2/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation

The Bcl2 family: regulators of the cellular life-or-death switch

Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032 · see citing works

Chk1 and Chk2 kinases in checkpoint control and cancer

Bartek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00110-7 · Cited by 1,513 · see citing works

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320 · see citing works

Reactive oxygen species in cancer cells: Live by the sword, die by the sword

Schumacker, P. T. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.015 · Cited by 1,242 · see citing works

Reactive Oxygen Species as Intracellular Messengers During Cell Growth and Differentiation

Sauer, H., Wartenberg, M., & Hescheler, J. (2001) · Cellular Physiology and Biochemistry · doi:10.1159/000047804 · Cited by 1,118 · see citing works

cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2

Gautier, J., Solomon, M. J., Booher, R. N., Bazán, J. F., & Kirschner, M. W. (1991) · Cell · doi:10.1016/0092-8674(91)90583-k · Cited by 843 · see citing works

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

Matsuoka, S., Rotman, G., Ogawa, A., Shiloh, Y., Tamai, K., & Elledge, S. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.190030497 · Cited by 830 · see citing works

Reactive oxygen species in tumorigenesis.

Feig, D. I., Reid, T. M., & Loeb, L. A. (1994) · PubMed · Cited by 472 · see citing works

Reactive Oxygen Species Generation and Mitochondrial Dysfunction in the Apoptotic Response to Bortezomib, a Novel Proteasome Inhibitor, in Human H460 Non-small Cell Lung Cancer Cells

Ling, Y., Liebes, L., Zou, Y., & Perez-Soler, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302559200 · Cited by 458 · see citing works

Properties of the caspases

Stennicke, H. R., & Salvesen, G. S. (1998) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(98)00133-2 · Cited by 373 · see citing works

Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells

Ka, H., Park, H.-J., Jung, H., Choi, J.-W., Cho, K.-S., Ha, J., & Lee, K. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00238-6 · Cited by 361 · see citing works

Reactive oxygen species and the mitochondrial signaling pathway of cell death.

Bras, M. L., Clément, M.-V., Pervaiz, S., & Brenner, C. (2005) · PubMed · doi:10.14670/hh-20.205 · Cited by 359 · see citing works

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1

Melchionna, R., Chen, X., Blasina, A., & McGowan, C. H. (2000) · Nature Cell Biology · doi:10.1038/35036406 · Cited by 307 · see citing works

A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation

OH, S., & Lim, S. S. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.07.018 · Cited by 283 · see citing works

Flavonoids Inhibit Cell Growth and Induce Apoptosis in B16 Melanoma 4A5 Cells

Iwashita, K., Kobori, M., Yamaki, K., & Tsushida, T. (2000) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.64.1813 · Cited by 256 · see citing works

Molecular pathogenesis of human hepatocellular carcinoma

Wang, X. W., Hussain, S. P., Huo, T., Wu, C.-G., Forgues, M., Hofseth, L. J., Bréchot, C., & Harris, C. C. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00253-6 · Cited by 246 · see citing works

Reactive Oxygen Species Mediate Caspase Activation and Apoptosis Induced by Lipoic Acid in Human Lung Epithelial Cancer Cells through Bcl-2 Down-Regulation

Moungjaroen, J., Nimmannit, U., Callery, P. S., Wang, L., Azad, N., Lipipun, V., Pithi Chanvorachote, B., & Rojanasakul, Y. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.110965 · Cited by 217 · see citing works

The ATM protein is required for sustained activation of NF-κB following DNA damage

Piret, B., Schoonbroodt, S., & Piette, J. (1999) · Oncogene · doi:10.1038/sj.onc.1202541 · Cited by 176 · cited 1× · see citing works

Reactive Oxygen Species (ROS), Troublemakers between Nuclear Factor-κB (NF-κB) and c-Jun NH2-terminal Kinase (JNK)

Zhang, Y., & Chen, F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3361 · Cited by 173 · see citing works

Systemic therapy for advanced hepatocellular carcinoma: a review

Nowak, A. K., Chow, P. K. H., & Findlay, M. P. N. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.02.027 · Cited by 168 · see citing works

Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway

Kim, B.-C., Kim, H.-G., Lee, S.-A., Lim, S., Park, E.-H., Kim, S., & Lim, C. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.07.025 · Cited by 159 · see citing works

Isoobtusilactone A Induces Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species/Apoptosis Signal-Regulating Kinase 1 Signaling Pathway in Human Breast Cancer Cells

Kuo, P., Chen, C., & Hsu, Y. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1089 · Cited by 152 · see citing works

Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment

Haddad, J. J. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.02.002 · Cited by 137 · see citing works

Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells

Jang, H.-S., Kook, S., Son, Y., et al. (2005) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.08.010 · Cited by 120 · see citing works

Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation

Yit, C. C., & Das, N. P. (1994) · Cancer Letters · doi:10.1016/0304-3835(94)90147-3 · Cited by 117 · see citing works

Baicalin induces apoptosis via mitochondrial pathway as prooxidant

Ueda, S., Nakamura, H., Masutani, H., et al. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(01)00115-8 · Cited by 110 · see citing works

The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase

Wang, Y., Chan, F. L., Chen, S., et al. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.12.014 · Cited by 106 · see citing works

The chalcone butein from Rhus verniciflua Stokes inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts

Samoszuk, M. K., Tan, J., & Chorn, G. (2005) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-5-5 · Cited by 83 · see citing works

Butein, a Plant Polyphenol, Induces Apoptosis Concomitant with Increased Caspase-3 Activity, Decreased Bcl-2 Expression and Increased Bax Expression in HL-60 Cells

Kim, N., Pae, H., Oh, G., et al. (2001) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2001.d01-114.x · Cited by 65 · see citing works

Ginsenoside-Rh2-Induced Mitochondrial Depolarization and Apoptosis Are Associated with Reactive Oxygen Species- and Ca2+-Mediated c-Jun NH2-Terminal Kinase 1 Activation in HeLa Cells

Ham, Y., Jin-Hee, L., Na, H., Choi, J., Park, B.-D., Yim, H., & Lee, S. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.109926 · Cited by 58 · see citing works

Eupalmerin acetate, a novel anticancer agent from Caribbean gorgonian octocorals, induces apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway

Iwamaru, A., Iwado, E., Kondo, S., Newman, R. A., Vera, B., Rodrı́guez, A. D., & Kondo, Y. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0422 · Cited by 55 · see citing works

Ubisemiquinone radicals in liver: Implications for a mitochondrial Q cycle in vivo

Davies, K. J. A., & Hochstein, P. E. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(82)80138-1 · Cited by 44 · see citing works

2′,4′,6′-Tris(methoxymethoxy) chalcone attenuates hepatic stellate cell proliferation by a heme oxygenase-dependent pathway

Lee, S. H., Seo, G. S., Kim, H. S., Woo, S. W., Ko, G., & Sohn, D. H. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.004 · Cited by 40 · see citing works

Detection of Oxidative Stress in Lymphocytes Using Dichlorodihydrofluorescein Diacetate

Krejsa, C. M., & Schieven, G. L. (2003) · Humana Press eBooks · doi:10.1385/1-59259-054-3:35 · Cited by 30 · see citing works

Enhancement of DNA topoisomerase I inhibitor–induced apoptosis by ursodeoxycholic acid

Ikegami, T., Matsuzaki, Y., Alrashid, M. H., et al. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0107 · Cited by 26 · see citing works

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works

The Two Faces of Reactive Oxygen Species in Cancer

Reczek, C. R., & Chandel, N. S. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-041916-065808 · Cited by 602 · see citing works

ROS in Cancer: The Burning Question

Chio, I. I. C., & Tuveson, D. A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.03.004 · Cited by 532 · see citing works

The multifaceted role of reactive oxygen species in tumorigenesis

Kirtonia, A., Sethi, G., & Garg, M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03536-5 · Cited by 452 · see citing works

Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y

Escobar, S. J. D. M., Fong, G. M., Winnischofer, S. M. B., Simone, M., Munoz, L., Dennis, J. M., Rocha, M. E. M., & Witting, P. K. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.11.022 · Cited by 33 · see citing works

Reactive oxygen species and programmed cell death

Jacobson, M. D. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)20008-8 · Cited by 753 · see citing works

Role of mitochondrial reactive oxygen species in chemically-induced ferroptosis

Song, X., Hao, X., & Zhu, B. T. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.07.006 · Cited by 37 · see citing works

Cdc2 Phosphorylation of Crb2 Is Required for Reestablishing Cell Cycle Progression after the Damage Checkpoint

Esashi, F., & Yanagida, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80364-0 · Cited by 79 · see citing works

HIV-1 Vpr induces G2 cell cycle arrest in fission yeast associated with Rad24/14-3-3-dependent, Chk1/Cds1-independent Wee1 upregulation

Matsuda, N., Tanaka, H., Yamazaki, S., et al. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.08.003 · Cited by 20 · see citing works

Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint

Elder, R. T., Yu, M. A., Chen, M., et al. (2000) · Virus Research · doi:10.1016/s0168-1702(00)00167-2 · Cited by 44 · see citing works