Cited by 371Seaweed-derived Bioactive CompoundsPolysaccharides Composition and ApplicationsMarine and coastal plant biology

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Microwave assisted extraction of sulfated polysaccharides (fucoidan) from Ascophyllum nodosum and its antioxidant activity

Yuan, Yuan, Macquarrie, Duncan·2015·Carbohydrate Polymers

DOI 10.1016/j.carbpol.2015.04.057

Open this paper in CoChat — free account

Abstract

Sulfated polysaccharides (fucoidan) from brown seaweed Ascophyllum nodosum were extracted by microwave assisted extraction (MAE) technology. Different conditions of temperature (90-150°C), extraction time (5-30 min) were evaluated and optimal fucoidan yield was 16.08%, obtained from 120°C for 15 min's extraction. Compositional analysis, GPC, HPAEC and IR analysis were employed for characterization of extracted sulfated polysaccharides. Fucose was the main monosaccharide of fucoidan extracted at 90°C while glucuronic acid was the main monosaccharide of fucoidan extracted at 150°C. Both the molecular weight and sulfate content of extracted fucoidan increased with decreasing extraction temperature. All fucoidans exhibited antioxidant activities as measured by DPPH scavenging and reducing power, among which fucoidan extracted at 90°C was highest. This study shows that MAE is an efficient technology to extract sulfated polysaccharides from seaweed and Ascophyllum nodosum could potentially be a resource for natural antioxidants.

Integrity signals

Registry

Crossref · 10.1016/j.carbpol.2015.04.057

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Colorimetric Method for Determination of Sugars and Related Substances
DuBois, M., Gilles, K. A., Hamilton, J. K., Rebers, P. A., & Smith, F. (1956) · Analytical Chemistry · doi:10.1021/ac60111a017 · Cited by 52,269
A note on the determination of the ester sulphate content of sulphated polysaccharides
Dodgson, K. S., & Price, R. (1962) · Biochemical Journal · doi:10.1042/bj0840106 · Cited by 1,645
Measurement of uronic acids without interference from neutral sugars
Filisetti-Cozzi, T. M. C. C., & Carpita, N. C. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90372-z · Cited by 1,446
A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., et al. (2007) · Glycobiology · doi:10.1093/glycob/cwm014 · Cited by 1,026
Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds
Ale, M. T., Mikkelsen, J. D., & Meyer, A. S. (2011) · Marine Drugs · doi:10.3390/md9102106 · Cited by 779
Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast Portugal: Individual cap and stipe activity
Ferreira, I. C. F. R., Baptista, P. C., Vilas‐Boas, M., & Barros, L. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2005.11.043 · Cited by 748
Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica
Wang, J., Zhang, Q., Zhang, Z., & Li, Z. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.10.003 · Cited by 745
Solvent-free microwave extraction of essential oil from aromatic herbs: comparison with conventional hydro-distillation
Lucchesi, M. E., Chemat, F., & Smadja, J. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.05.083 · Cited by 656
Characterization of polysaccharides extracted from brown seaweeds
Rioux, L.-E., Turgeon, S. L., & Beaulieu, M. (2007) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2007.01.009 · Cited by 604
Microwave-assisted extraction of tea polyphenols and tea caffeine from green tea leaves
Pan, X., Niu, G., & Liu, H. (2003) · Chemical Engineering and Processing - Process Intensification · doi:10.1016/s0255-2701(02)00037-5 · Cited by 568

Flagged first, then by citations

Show all 50 references

Sorted by citations

Items 101–200 of 371

Microwave Assisted Extraction and Pressurized Liquid Extraction of Sulfated Polysaccharides from Fucus virsoides and Cystoseira barbata
Dobrinčić, A., Pedišić, S., Zorić, Z., Jurin, M., Roje, M., Čož‐Rakovac, R., & Dragović‐Uzelac, V. (2021) · Foods · doi:10.3390/foods10071481 · Cited by 59
A Comparative Review of Alternative Fucoidan Extraction Techniques from Seaweed
Chadwick, M., Carvalho, L. G., Vanegas, C., & Dimartino, S. (2025) · Marine Drugs · doi:10.3390/md23010027 · Cited by 64
Recovery of high-value and scarce resources from biological wastewater treatment: Sulfated polysaccharides
Xue, W., Zeng, Q., Lin, S., Zan, F., Hao, T., Lin, Y., van Loosdrecht, M. C. M., & Chen, G. (2019) · Water Research · doi:10.1016/j.watres.2019.114889 · Cited by 59
Microwave-assisted hydrothermal extraction of non-structural carbohydrates and hemicelluloses from tobacco biomass
Yuan, Y., Zou, P., Zhou, J., Geng, Y., Fan, J., Clark, J. H., Li, Y., & Zhang, C. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115043 · Cited by 58
Self-citation
Ultrasound‐assisted extraction of sulfated polysaccharide from Nizamuddinia zanardinii : Process optimization, structural characterization, and biological properties
Alboofetileh, M., Rezaei, M., Tabarsa, M., & You, S. (2018) · Journal of Food Process Engineering · doi:10.1111/jfpe.12979 · Cited by 54
Bioactive Algal-Derived Polysaccharides: Multi-Functionalization, Therapeutic Potential and Biomedical Applications
Muhamad, I. I., Zulkifli, N., Selvakumaran, S., & Lazim, N. A. M. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190618152133 · Cited by 55
Purification and Molecular Characterization of Fucoidan Isolated from Ascophyllum nodosum Brown Seaweed Grown in Ireland
Rajauria, G., Ravindran, R., Garcia-Vaquero, M., Rai, D., Sweeney, T., & O'Doherty, J. (2023) · Marine Drugs · doi:10.3390/md21050315 · Cited by 52
Impact of high pressure pre-treatment and hot water extraction on chemical properties of crude polysaccharide extract obtained from mushroom (Volvariella volvacea)
Tepsongkroh, B., Thaihuttakij, C., Supawong, S., & Jangchud, K. (2023) · Food Chemistry X · doi:10.1016/j.fochx.2023.100864 · Cited by 54
Effect of carboxymethylation on properties of fucoidan from Laminaria japonica: Antioxidant activity and preservative effect on strawberry during cold storage
Duan, Z., Duan, W., Li, F., Li, Y., Luo, P., & Liu, H. (2019) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2019.02.008 · Cited by 54
Extraction technology impacts on the structure-function relationship between sodium alginate extracts and their in vitro prebiotic activity
Okolie, C. L., Mason, B., Mohan, A., Pitts, N., & Udenigwe, C. C. (2020) · Food Bioscience · doi:10.1016/j.fbio.2020.100672 · Cited by 47
Assessment of the antibacterial and antioxidant activities of seaweed-derived extracts
Hejna, M., Dell’Anno, M., Liu, Y., Rossi, L., Aksmann, A., Pogorzelski, G., & Jóźwik, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-71961-8 · Cited by 59
Cascaded valorization of seaweed using microbial cell factories
Poblete‐Castro, I., Hoffmann, S. L., Becker, J., & Wittmann, C. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.02.008 · Cited by 53
Characterization and biological activity of acidic sugarcane leaf polysaccharides by microwave-assisted hot alkali extraction
Jiang, F., Sheng, Y., Wang, F., Pan, H., Chen, W., & Kong, F. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102852 · Cited by 52
Ulvans induce resistance against plant pathogenic fungi independently of their sulfation degree
de Freitas, M. B., Ferreira, L. G., Hawerroth, C., Duarte, M. E. R., Noseda, M. D., & Stadnik, M. J. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.07.055 · Cited by 50
Exploiting the Amazing Diversity of Natural Source-Derived Polysaccharides: Modern Procedures of Isolation, Engineering, and Optimization of Antiviral Activities
Ray, B., Schütz, M., Mukherjee, S., Jana, S., Ray, S., & Marschall, M. (2020) · Polymers · doi:10.3390/polym13010136 · Cited by 50
Combined process of high-pressure homogenization and hydrothermal extraction for the extraction of fucoidan with good antioxidant properties from Nemacystus decipients
Guo-ying, L., Luo, Z., Yuan, F., & Yu, X. (2017) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2017.08.002 · Cited by 49
Fucoidan alleviates microcystin-LR-induced hepatic, renal, and cardiac oxidative stress and inflammatory injuries in mice
AlKahtane, A. A., Abushouk, A. I., Mohammed, E. T., ALNasser, M., Alarifi, S., Ali, D., Alessia, M. S., Almeer, R. S., AlBasher, G., Alkahtani, S., et al. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-06931-z · Cited by 48
Complementarity of Raman and Infrared spectroscopy for rapid characterization of fucoidan extracts
Ptak, S. H., Sanchez, L., Fretté, X. C., & Kurouski, D. (2021) · Plant Methods · doi:10.1186/s13007-021-00830-6 · Cited by 48
An active heteropolysaccharide from the rinds of Garcinia mangostana Linn.: Structural characterization and immunomodulation activity evaluation
Zhang, S., An, L., Li, Z., Wang, H., Shi, L., Zhang, J., Li, Y., Jin, D., Tuerhong, M., Ohizumi, Y., et al. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.115929 · Cited by 48
A critical review on extraction, characteristics, physicochemical activities, potential health benefits, and industrial applications of fucoidan
Du, B., Zhao, Q., Cheng, C., Wang, H., Liu, Y., Zhu, F., & Yang, Y. (2022) · eFood · doi:10.1002/efd2.19 · Cited by 47
Pectic Oligosaccharides and Other Emerging Prebiotics
Míguez, B., Gómez, B., Gullón, P., Gullón, B., & Alonsó, J. L. (2016) · InTech eBooks · doi:10.5772/62830 · Cited by 47
Sequential and enzyme-assisted extraction of algal bioproducts from Ecklonia maxima
Mabate, B., & Pletschke, B. I. (2023) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2023.110364 · Cited by 51
Extraction, characterization and antioxidant activities of polysaccharides of Chuanminshen violaceum
Dong, H., Zhang, Q. R., Li, Y., Lü, L., Lan, W., He, J., Li, H., Xiong, Y., & Qin, W. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.01.002 · Cited by 45
Extraction optimization, physicochemical characterization, and antioxidant activity of polysaccharides from Rhodosorus sp. SCSIO-45730
Wang, N., Dai, L., Chen, Z., Tao, L., Wu, J., Wu, H., Wu, H., & Xiang, W. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-021-02646-2 · Cited by 45
Advancement of biorefinery-derived platform chemicals from macroalgae: a perspective for bioethanol and lactic acid
Tong, K. T. X., Tan, I. S., Foo, H. C. Y., Lam, M. K., Lim, S., & Lee, K. T. (2022) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-022-02561-7 · Cited by 48
Systematic Characteristics of Fucoidan: Intriguing Features for New Pharmacological Interventions
Jeong, S., Lee, S., Lee, G.-T., Hyun, J., & Ryu, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111771 · Cited by 45
Optimization of an aqueous two-phase extraction method for the selective separation of sulfated polysaccharides from a crude natural mixture
Du, L.-P., Cheong, K., & Liu, Y. (2018) · Separation and Purification Technology · doi:10.1016/j.seppur.2018.03.071 · Cited by 43
Physicochemical properties and laxative effects of polysaccharides from Anemarrhena asphodeloides Bge. in loperamide-induced rats
Li, X., Liu, Y., Guan, W., Xia, Y., Zhou, Y., Yang, B., & Kuang, H. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.111961 · Cited by 42
Green and integrated processing approaches for the recovery of high-value compounds from brown seaweeds
Bordoloi, A., & Goosen, N. J. (2019) · Advances in botanical research · doi:10.1016/bs.abr.2019.11.011 · Cited by 43
Purification and Structural Characterization of Sulfated Polysaccharides Derived from Brown Algae, Sargassum binderi: Inhibitory Mechanism of iNOS and COX-2 Pathway Interaction
Je, J.-G., Lee, H.-G., Fernando, K. H. N., Jeon, Y., & Ryu, B. (2021) · Antioxidants · doi:10.3390/antiox10060822 · Cited by 41
Characterization and Cytotoxic Activity of Microwave-Assisted Extracted Crude Fucoidans from Different Brown Seaweeds
Zayed, A., Finkelmeier, D., Hahn, T., Rebers, L., Shanmugam, A., Burger‐Kentischer, A., & Ulber, R. (2023) · Marine Drugs · doi:10.3390/md21010048 · Cited by 43
Overview on Microbial Enzymatic Production of Algal Oligosaccharides for Nutraceutical Applications
Jagtap, A. S., & Manohar, C. S. (2021) · Marine Biotechnology · doi:10.1007/s10126-021-10027-6 · Cited by 43
A critical review on pharmacological properties of sulfated polysaccharides from marine macroalgae
Jegadeshwari, B., & Rajaram, R. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122488 · Cited by 42
Magnetic graphene oxide modified by imidazole‐based ionic liquids for the magnetic‐based solid‐phase extraction of polysaccharides from brown alga
Wang, X., Li, G., & Row, K. H. (2017) · Journal of Separation Science · doi:10.1002/jssc.201700393 · Cited by 38
Polysaccharides from Diaphragma juglandis fructus: Extraction optimization, antitumor, and immune-enhancement effects
Meng, Q., Wang, Y., Chen, F., Xiao, T., & Zhang, L. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.04.121 · Cited by 37
Optimization of ultrasonic‐microwave synergistic extraction of polysaccharides from Morchella conica
Xu, N., Sun, Y.-H., Guo, X., Liu, C., Mao, Q., & Hou, J. (2018) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.13423 · Cited by 34
Fucoidan from acid-processed Hizikia fusiforme attenuates oxidative damage and regulate apoptosis
Dai, Y., Jiang, Y.-F., Lu, Y., Kang, M., & Jeon, Y. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.05.143 · Cited by 34
High value-added biomaterials recovery from granular sludge based wastewater treatment process
Tan, X., Xie, G.-J., Nie, W.-B., Xing, D., Liu, B.-F., Ding, J., & Ren, N. (2021) · Resources Conservation and Recycling · doi:10.1016/j.resconrec.2021.105481 · Cited by 34
Sustainable production of biofuels and bioderivatives from aquaculture and marine waste
Alvarado-Ramírez, L., Santiesteban-Romero, B., Poss, G., Sosa‐Hernández, J. E., Iqbal, H. M. N., Parra‐Saldívar, R., Bonaccorso, A. D., & Melchor-Martínez, E. M. (2023) · Frontiers in Chemical Engineering · doi:10.3389/fceng.2022.1072761 · Cited by 41
Physicochemical Characterization, Antioxidant and Immunostimulatory Activities of Sulfated Polysaccharides Extracted from Ascophyllum nodosum
Chen, L., Wang, Y., Yang, H., Li, H., Xu, W., Chen, G., & Zhu, H. (2018) · Molecules · doi:10.3390/molecules23081912 · Cited by 33
Sulfated Polysaccharides from Macroalgae for Bone Tissue Regeneration
Venkatesan, J., Anil, S., Rao, S. S., Bhatnagar, I., & Kim, S. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190425161630 · Cited by 33
Inhibition of Calcium Oxalate Formation and Antioxidant Activity of Carboxymethylated Poria cocos Polysaccharides
Li, C., Liu, L., Zhao, Y., Chen, J.-Y., Sun, X., & Ouyang, J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6653593 · Cited by 33
Fucoidan Protects against Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Preventing Mitochondrial Function Injury
Ji, Y., Jin, D., Qi, J., Wang, X., Zhang, C., An, P., Luo, Y., & Luo, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810685 · Cited by 33
Fucoidans of Moroccan Brown Seaweed as Elicitors of Natural Defenses in Date Palm Roots
Bouissil, S., Alaoui-Talibi, Z. E., Pierre, G., Rchid, H., Michaud, P., Delattre, C., & Modafar, C. E. (2020) · Marine Drugs · doi:10.3390/md18120596 · Cited by 34
Continuous microwave-assisted step-by-step extraction of bioactive water-soluble materials and fucoidan from brown seaweed Undaria pinnatifida waste
Sasaki, C., Tamura, S., Suzuki, M., Etomi, K., Nii, N., Hayashi, J., & Kanemaru, K. (2022) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-022-03035-6 · Cited by 33
Structural characterization of a fucoidan from Ascophyllum nodosum and comparison of its protective effect against cellular oxidative stress with its analogues
Wang, L., Wang, L., Yan, C., Fu, Y., Yang, J., Ma, J., & Song, S. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124295 · Cited by 32
Molecular Mechanisms Underlying Cancer Preventive and Therapeutic Potential of Algal Polysaccharides
Sajadimajd, S., Momtaz, S., Haratipour, P., El‐Senduny, F. F., Iranpanah, A., Navabi, J., Soheilikhah, Z., Farzaei, M. H., & Rahimi, R. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190425155126 · Cited by 31
Brown seaweeds as a source of anti-hyaluronidase compounds
Arunkumar, K., Raj, R., Raja, R., & Carvalho, I. S. (2021) · South African Journal of Botany · doi:10.1016/j.sajb.2021.03.036 · Cited by 31
The current status and future perspective in combination of the processing technologies of sulfated polysaccharides from sea cucumbers: A comprehensive review
Li, Y., Li, M., Xu, B., Li, Z., Qi, Y., Song, Z., Zhao, Q., Du, B., & Yang, Y. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104744 · Cited by 31
Alkaline subcritical water extraction of bioactive compounds and antioxidants from beach-cast brown algae (Ascophyllum Nodosum)
Zhang, Y., Hawboldt, K., MacQuarrie, S., Thomas, R., & Gebregiworgis, T. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.153109 · Cited by 30
Molecularly Imprinted Polymers Modified by Deep Eutectic Solvents and Ionic Liquids with Two Templates for the Simultaneous Solid-Phase Extraction of Fucoidan and Laminarin from Marine Kelp
Li, G., Dai, Y., Wang, X., & Row, K. (2018) · Analytical Letters · doi:10.1080/00032719.2018.1471697 · Cited by 30
Ascophyllum nodosum (Linnaeus) Le Jolis from Arctic: Its Biochemical Composition, Antiradical Potential, and Human Health Risk
Obluchinskaya, E. D., Pozharitskaya, O. N., Горшенина, Е. В., Даурцева, А. В., Флисюк, Е. В., Generalova, Y. E., Terninko, I. I., & Shikov, A. N. (2024) · Marine Drugs · doi:10.3390/md22010048 · Cited by 28
Biomineralization of Fucoidan-Peptide Blends and Their Potential Applications in Bone Tissue Regeneration
Pajovich, H. T., & Banerjee, I. A. (2017) · Journal of Functional Biomaterials · doi:10.3390/jfb8030041 · Cited by 28
Optimization of ultrasound‐assisted extraction of functional polysaccharides from common mullein (Verbascum thapsus L.) flowers
Babamoradi, N., Yousefi, S., & Ziarati, P. (2018) · Journal of Food Process Engineering · doi:10.1111/jfpe.12851 · Cited by 31
Structural and bioactive roles of fucoidan in nanogel delivery systems. A review
Ramos-de-la-Peña, A. M., Contreras‐Esquivel, J. C., Aguilar, O., & González‐Valdez, J. (2022) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2022.100235 · Cited by 29
Macroalgae Biorefinery for the Cosmetic Industry: Basic Concept, Green Technology, and Safety Guidelines
Hempel, M. D. S. S., Colepicolo, P., & Zambotti‐Villela, L. (2023) · Phycology · doi:10.3390/phycology3010014 · Cited by 28
Recent update on alginate based promising transdermal drug delivery systems
Manna, S., Gupta, P., Nandi, G., & Jana, S. (2023) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2023.2230847 · Cited by 28
Relevance of the Extraction Stage on the Anti-Inflammatory Action of Fucoidans
Flórez-Fernández, N., Vaamonde‐García, C., Torres, M. D., Buján, M., Muíños, A., Muiños, A., Lamas-Vázquez, M. J., Meijide-Faílde, R., Blanco, F. J., & Domı́nguez, H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030808 · Cited by 29
Insights into immunoregulatory effects of bioactive polysaccharides derived from seaweeds through gut microbiota
Wijesekara, T., Huang, R., Wong, I. N., & Xu, B. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103800 · Cited by 27
Current Review: Alginate in the Food Applications
Pournaki, S. K., Alemán, R. S., Azhdari, S. M. H., Marcía, J., Yadav, A., & Moncada, M. L. (2024) · J — Multidisciplinary Scientific Journal · doi:10.3390/j7030016 · Cited by 30
Bioactive polysaccharides and their derivatives from microalgae: biosynthesis, applications, and challenges
Yi, Z., Su, Y., Brynjólfsson, S., Ólafsdóttir, K. B., & Fu, W. (2021) · Studies in natural products chemistry · doi:10.1016/b978-0-323-91095-8.00007-6 · Cited by 28
Fucoidan isolated from fermented Sargassum fusiforme suppresses oxidative stress through stimulating the expression of superoxidase dismutase and catalase by regulating Nrf2 signaling pathway
Wang, L., Cui, Y. R., Lee, H.-G., Fu, X., Wang, K., Xu, J., Gao, X., & Jeon, Y. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.04.083 · Cited by 27
Mixture of Phlorotannin and Fucoidan from Ecklonia cava Prevents the Aβ-Induced Cognitive Decline with Mitochondrial and Cholinergic Activation
Han, H. J., Park, S. K., Kang, J. Y., Kim, J. M., Yoo, S. K., Kim, D., Kim, G., & Heo, H. J. (2021) · Marine Drugs · doi:10.3390/md19080434 · Cited by 28
Two Ascophyllum nodosum Fucoidans with Different Molecular Weights Inhibit Inflammation via Blocking of TLR/NF-κB Signaling Pathway Discriminately
Wang, L., Wang, L., Yan, C., Ai, C., Wen, C., Guo, X., & Song, S. (2022) · Foods · doi:10.3390/foods11152381 · Cited by 30
Polysaccharide from Cordyceps cicadae inhibit mitochondrial apoptosis to ameliorate drug-induced kidney injury via Bax/Bcl-2/Caspase-3 pathway
Zhu, L., Yu, T., Li, Y., Liu, T., Song, Z., Liu, S., Zhang, D., & Tang, C. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105244 · Cited by 26
Extraction optimization, preliminary characterization and antioxidant activities of polysaccharides from Glycine soja
Jing, C., Yuan, Y., Tang, Q., Zou, P., Li, Y., & Zhang, C. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.05.186 · Cited by 26
Self-citation
Air-drying and rehydration characteristics of the brown seaweeds, Ascophylum nodosum and Undaria pinnatifida
Chenlo, F., Arufe, S., Díaz, D. G., Torres, M. D., Sineiro, J., & Moreira, R. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1300-6 · Cited by 26
Valorisation of the industrial hybrid carrageenan extraction wastes using eco-friendly treatments
Bianchi, A., Sanz, V., Domı́nguez, H., & Torres, M. D. (2021) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2021.107070 · Cited by 26
The effects of fucoidan‐rich polysaccharides extracted from Sargassum horneri on enhancing collagen‐related skin barrier function as a potential cosmetic product
Kang, J., Hyun, S. H., Kim, H., Park, S., Lee, J., Lee, I., & Bae, J. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16108 · Cited by 28
A comprehensive review to assess the potential, health benefits and complications of fucoidan for developing as functional ingredient and nutraceutical
Senthil, S. L. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134226 · Cited by 27
Ultrasonic-assisted enzymatic extraction of sulfated polysaccharide from Skipjack tuna by-products
Naghdi, S., Rezaei, M., Tabarsa, M., & Abdollahi, M. (2023) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2023.106385 · Cited by 25
A Microwave-Assisted Simultaneous Distillation and Extraction Method for the Separation of Polysaccharides and Essential Oil from the Leaves of Taxus chinensis Var. mairei
Zhao, C., He, X., Li, C., Yang, L., Fu, Y., Wang, K., Zhang, Y., & Ni, Y. (2016) · Applied Sciences · doi:10.3390/app6020019 · Cited by 25
Unlocking marine potential: Microwave-assisted extraction of bioactive compounds from marine macroalgae
Gonzaga, L. J., Roa, M. E. P., Lavecchia, R., & Zuorro, A. (2025) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2025.116858 · Cited by 27
Determination of thermal transitions of gluten-free chestnut flour doughs enriched with brown seaweed powders and antioxidant properties of baked cookies
Arufe, S., Sineiro, J., & Moreira, R. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01805 · Cited by 25
Isolation and purification of fucoidan from Sargassum ilicifolium: Osteogenic differentiation potential in mesenchymal stem cells for bone tissue engineering
Yashaswini Devi, G. V., Nagendra, A. H., Sudheer Shenoy, P., Chatterjee, K., & Venkatesan, J. (2022) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2022.104418 · Cited by 26
Comparative Analyses of Fucoidans from South African Brown Seaweeds That Inhibit Adhesion, Migration, and Long-Term Survival of Colorectal Cancer Cells
Mabate, B., Daub, C. D., Pletschke, B. I., & Edkins, A. L. (2023) · Marine Drugs · doi:10.3390/md21040203 · Cited by 26
Microwave-Assisted Water Extraction
Seoane, P., Flórez-Fernández, N., Piñeiro, E., & González, H. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809380-1.00006-1 · Cited by 19
Extraction Optimization of Polysaccharides from Wet Red Microalga Porphyridium purpureum Using Response Surface Methodology
Chen, Y., Li, Q., Xu, B., Xiang, W., Li, A., & Li, T. (2024) · Marine Drugs · doi:10.3390/md22110498 · Cited by 23
Study of phenolic-polysaccharide interactions in brown seaweed
Lee, Z. J., Xie, C., Ng, K., & Suleria, H. A. R. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.143494 · Cited by 23
Comparative Evaluation of Dynamic Maceration and Ultrasonic Assisted Extraction of Fucoidan from Four Arctic Brown Algae on Its Antioxidant and Anticancer Properties
Obluchinskaya, E. D., Pozharitskaya, O. N., Lapina, I. M., Kulminskaya, A. A., Zhurishkina, E. V., & Shikov, A. N. (2025) · Marine Drugs · doi:10.3390/md23060230 · Cited by 25
Fucoidan - a valuable source from the ocean to pharmaceutical
Pacheco, D., García‐Poza, S., Cotas, J., Gonçalves, A. M. M., & Pereira, L. (2020) · Frontiers in Drug Chemistry and Clinical Research · doi:10.15761/fdccr.1000141 · Cited by 24
Microwave-assisted extraction of proteins and carbohydrates from marine resources
Sharma, P., & Zalpouri, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820096-4.00019-5 · Cited by 23
Fucoidan from Ascophyllum nodosum and Undaria pinnatifida attenuate SARS-CoV-2 infection in vitro and in vivo by suppressing ACE2 and alleviating inflammation
Shi, F., Xie, Y.-H., Yang, Y., Xu, L.-D., Li, J., Wang, X., Zhu, L.-Y., Feng, Y., Wang, W.-W., Shen, P., et al. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.121884 · Cited by 24
Application of Green Extraction Techniques for Natural Additives Production
Carreira-Casais, A., Lourenço‐Lopes, C., Otero, P., Carpena, M., Pereira, A. G., Echave, J., Soria-López, A., Chamorro, F., Prieto, M. A., & Simal‐Gándara, J. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.100320 · Cited by 26
Study on physicochemical properties and antioxidant activity of polysaccharides from Desmodesmus armatus
Cao, M., Wang, S., Gao, Y., Pan, X., Wang, X., Deng, R., & Liu, P. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13243 · Cited by 22
Evaluation of the properties of polysaccharides extracted from brown macroalgae (Sargassum ilicifolium) by methods of conventional, microwave, and subcritical water extraction
Bahrami, S., Nateghi, L., Rashidi, L., Nobandegani, B. K., & Ghorbanpour, M. (2025) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2025.103975 · Cited by 21
Feasibility of posthydrolysis processing of hydrothermal extracts from Sargassum muticum
Flórez-Fernández, N., González‐Muñoz, M. J., & Domı́nguez, H. (2017) · Algal Research · doi:10.1016/j.algal.2017.08.002 · Cited by 21
Understanding Mechanism of Adsorption in the Decolorization of Aqueous Methyl Violet (6B) Solution by Okra Polysaccharides: Experiment and Theory
Wang, M., Gu, Q., Luo, Y., Bukhvalov, D., Ma, X., Zhu, L., Li, G., & Luo, Z. (2019) · ACS Omega · doi:10.1021/acsomega.9b02768 · Cited by 21
Advances in Genetic Tools and Their Application in Streptococcus thermophilus
Zhao, R., Chen, Z., Liang, J., Dou, J., Guo, F., Xu, Z., & Wang, T. (2023) · Foods · doi:10.3390/foods12163119 · Cited by 21
Technology comparison for sequential extraction of fucoidan and sodium alginate from Ascophyllum nodosum using a glycerol and choline chloride solvent
James, K., Ramirez, J., Barner, L., & Moghaddam, L. (2023) · Cleaner Engineering and Technology · doi:10.1016/j.clet.2023.100707 · Cited by 21
Ecofriendly conversion of algal waste into valuable plant growth-promoting rhizobacteria (PGPR) biomass
Yuan, Y., Chu, D., Fan, J., Zou, P., Qin, Y., Geng, Y., Cui, Z., Wang, X., Zhang, C., Li, X., et al. (2020) · Waste Management · doi:10.1016/j.wasman.2020.10.020 · Cited by 20
Self-citation
The effectiveness of the Fucus virsoides and Cystoseira barbata fucoidan isolation as a function of applied pre-treatment and extraction conditions
Dobrinčić, A., Dobroslavić, E., Pedišić, S., Balbino, S., Garofulić, I. E., Čož‐Rakovac, R., & Dragović‐Uzelac, V. (2021) · Algal Research · doi:10.1016/j.algal.2021.102286 · Cited by 20
Potential of a fucoidan-rich Ascophyllum nodosum extract to reduce Salmonella shedding and improve gastrointestinal health in weaned pigs naturally infected with Salmonella
Venardou, B., O’Doherty, J. V., Maher, S., Ryan, M. T., Gath, V., Ravindran, R., Kiely, C., Rajauria, G., García‐Vaquero, M., & Sweeney, T. (2022) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-022-00685-4 · Cited by 20
Synthesis and evaluation of antibacterial and anti-oxidant activity of small molecular chitosan–fucoidan conjugate nanoparticles
Tsai, L., Tsai, M., Lu, K.-Y., & Mi, F. (2018) · Research on Chemical Intermediates · doi:10.1007/s11164-018-3341-0 · Cited by 20
Optimization of alginate extraction conditions from the brown seaweed Dictyota mertensii using a central composite design
Queiroz, L. P. D. O., Aroucha, E. M. M., dos Santos, F. K. G., & Leite, R. H. D. L. (2024) · Algal Research · doi:10.1016/j.algal.2024.103482 · Cited by 20
Comprehensive Review on the Biomedical Applications of Marine Algal Polysaccharides
Waoo, A. A., Singh, S., Chandra, N., Mishra, S., Singh, M. P., Mal, J., Jha, A. K., Joo, J. C., & Pandey, A. (2025) · Phycology · doi:10.3390/phycology5040080 · Cited by 21
Structural characterization and bioactive and functional properties of the Brown macroalgae (Sargassum illicifolium) polysaccharide
Ghanavati, P. A. Z., Khodadadi, M., & Tadayoni, M. (2022) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-022-01283-8 · Cited by 19
Beyond Nutrients: Exploring the Potential of Phytochemicals for Human Health
Alum, E. U., & Ugwu, O. P.-C. (2023) · IAA Journal of Applied Sciences · doi:10.59298/iaajas/2023/4.1.3211 · Cited by 19
Chemical characterization and bioactivities of polysaccharides from Apocynum venetum leaves extracted by different solvents
Zhou, J., Zou, P., Jing, C., Xu, Z., Zhou, S., Li, Y., Zhang, C., & Yuan, Y. (2019) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-019-00286-2 · Cited by 19
Self-citation
Seaweed-derived polysaccharides as antibacterial and antiviral ingredients
Cooney, O. C., Morrin, S. T., Buck, R. H., Owens, R. A., & Hickey, R. M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145823 · Cited by 18

Authors: Yuan, Y., & Macquarrie, D.
Affiliations: University of York (GB)
Corresponding author: Macquarrie, Duncan
ORCID: Yuan, Yuan
Macquarrie, Duncan
Venue: Carbohydrate Polymers
Publisher: Elsevier BV
Published: 2015-09
Volume: 129
Pages: 101-107
ISSN: 0144-8617 (ISSN-L)
DOI: 10.1016/j.carbpol.2015.04.057
OpenAlex: W317714569
Semantic Scholar: fe72b2f1446aba29dd8e23236f0f0027211ea81a
Cited by: 371
References: 50
Citations by year: 2026: 23 · 2025: 45 · 2024: 39 · 2023: 43 · 2022: 35 · 2021: 44 · 2020: 36 · 2019: 31 · 2018: 25 · 2017: 25 · 2016: 16 · 2015: 9
FWCI: 38.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Carbohydrate Polymers (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Keywords: fucoidan, sulfated polysaccharides, Ascophyllum nodosum, brown algae, microwave-assisted extraction, extraction temperature, extraction time, fucose, glucuronic acid, sulfate content, molecular weight, antioxidant activity, DPPH radical scavenging, reducing power, natural antioxidants
MeSH terms: Antioxidants, Biphenyl Compounds, Carbohydrates, Microwaves, Oxidation-Reduction, Picrates, Polysaccharides, Temperature, Time Factors, Uronic Acids, Free Radical Scavengers, Ascophyllum

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Microwave assisted extraction of sulfated polysaccharides (fucoidan) from Ascophyllum nodosum and its antioxidant activity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks