Cited by 115Pain Management and Opioid UseHeart Failure Treatment and ManagementPalliative Care and End-of-Life Issues

Investigating pain in heart failure patients: the Pain Assessment, Incidence, and Nature in Heart Failure (PAIN-HF) study

Goodlin, Sarah J., Wingate, Sue, Albert, Nancy M., Pressler, Susan J., Houser, Janet, Kwon, Jennifer, Chiong, Jun, Storey, C. Porter +2 more·2012·Journal of Cardiac Failure

Abstract

Background Patients with advanced heart failure (HF) have high rates of pain and other symptoms that diminish quality of life. We know little about the characteristics and correlates of pain in patients with advanced HF.Methods and results We identified pain prevalence, location, character, severity, frequency, and correlates in 347 outpatients with advanced HF enrolled from hospices and clinics. We evaluated the correlation of pain with HF-related quality of life, mortality, symptoms and health problems, and current treatments for pain. Pain at any site was reported by 293 patients (84.4%), and 138 (39.5%) reported pain at more than one site. The most common site of pain was the legs below the knees (32.3% of subjects). Pain interfered with activity for 70% of patients. Pain was "severe" or "very severe" for 28.6% of subjects with chest pain, and for 38.9% of those with other sites of pain. The only medication reported to provide pain relief was opioids, prescribed for 34.1% of subjects (P = .001). The strongest predictors of pain were degenerative joint disease (DJD) (odds ratio [OR] 14.95, 95% confidence interval [CI] 3.9-56.0; P < .001), other arthritis (OR 2.8, 95% CI 1.20-6.62; P = .017), shortness of breath (OR 3.27, 95% CI 1.47-7.28; P = .004), and angina pectoris (OR 3.38, 95% CI 1.30-8.81; P = .013).Conclusions Pain occurred at multiple sites in patients with advanced HF. Pain correlated with DJD or other arthritis, shortness of breath, and angina. Only opioid analgesics provided relief of pain. Future research should evaluate the etiology of and interventions to manage pain in patients with HF.

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Crossref · 10.1016/j.cardfail.2012.07.007

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  • Pain was most commonly cited in the legs and back, and more than a third experience pain in multiple sites.

    “While pain was most commonly cited in the legs and back, more than a third experience pain in multiple sites. 85”
  • Opiates have an important role in CHF both in the early and later palliative stages of the disease and are safe, well tolerated, and effective.

    “Opiates have an important role in CHF both in the early and later palliative stages of the disease and are safe, well tolerated, and effective. 85”

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Authors
Goodlin, S. J., Wingate, S., Albert, N. M., Pressler, S. J., Houser, J., Kwon, J., Chiong, J., Storey, C. P., Quill, T., & Teerlink, J. R.
Affiliations
  • Portland VA Medical Center (US)
  • Kaiser Permanente (US)
  • Cleveland Clinic (US)
  • University of Michigan (US)
  • Regis University (US)
  • Loma Linda University (US)
  • Loma Linda University Medical Center (US)
  • University of Rochester (US)
  • University of California, San Francisco (US)
Corresponding author
Goodlin, Sarah J.
Venue
Journal of Cardiac Failure
Publisher
Elsevier BV
Published
2012-10
Volume
18
Issue
10
Pages
776-783
ISSN
1071-9164 (ISSN-L)
OpenAlex
W2010931476
Cited by
115
References
23
Citations by year
2026: 7 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 8 · 2021: 14 · 2020: 10 · 2019: 14 · 2018: 4 · 2017: 13 · 2016: 9 · 2015: 7 · 2014: 5 · 2013: 3
FWCI
6.42
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cardiac Failure (publishedVersion)
  • PubMed (publishedVersion)
  • ePublications at Regis University (Regis University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
Keywords
heart failure, pain, advanced heart failure, pain prevalence, pain localization, pain intensity, quality of life, opioids, osteoarthritis, arthritis, dyspnea, angina pectoris, pain management, predictors of pain
MeSH terms
Aged, Female, Health Status Indicators, Heart Failure, Humans, Male, Middle Aged, Pain, Pain Measurement, Quality of Life, Surveys and Questionnaires, United States, Comorbidity, Incidence, Confidence Intervals, Odds Ratio

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