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Cited by 273

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

Vascular effects of wine polyphenols

DELLAGLI, M·2004·Cardiovascular Research
DOI 10.1016/j.cardiores.2004.03.019
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Abstract

Moderate consumption of red wine has been putatively associated with lowering the risk of developing coronary heart disease. This beneficial effect is mainly attributed to the occurrence of polyphenol compounds such as anthocyanosides (ACs), catechins, proanthocyanidins (PAs), stilbenes and other phenolics in red wine. This review focuses on the vascular effects of red wine polyphenols (RWPs), with emphasis on anthocyanosides and proanthocyanidins. From in vitro studies, the effect of red wine polyphenols on the vascular tone is thought to be due to short- and long-term mechanisms. NO-mediated vasorelaxation represents the short-term response to wine polyphenols, which exert the effect by increasing the influx of extracellular Ca(2+), and the mobilization of intracellular Ca(2+) in endothelial cells. Polyphenolic compounds may also have long-term properties, as they increase endothelial NO synthase expression acting on the promoter activity. In addition, they decrease the expression of adhesion molecules and growth factors, involved in migration and proliferation of vascular smooth muscle cells. Moreover, they inhibit platelet aggregation. However, a paucity of data as regards the bioavailability and metabolism of these compounds in human studies is a limiting factor to proving their efficacy in vivo.

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Metadata

Authors
DELLAGLI, M.
Venue
Cardiovascular Research
Publisher
Oxford University Press (OUP)
Published
2004-09
Volume
63
Issue
4
Pages
593-602
ISSN
0008-6363 (ISSN-L)
DOI
10.1016/j.cardiores.2004.03.019
OpenAlex
W2080967265
Cited by
273
References
99
FWCI
8.97
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Vascular effects of wine polyphenols. https://app.cochat.ai/papers/10.1016/j.cardiores.2004.03.019
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DELLAGLI, M. (2004). Vascular effects of wine polyphenols. Cardiovascular Research. https://doi.org/10.1016/j.cardiores.2004.03.019

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.