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Cited by 736

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

The role of oxidants and free radicals in reperfusion injury

ZWEIER, J, TALUKDER, M·2006·Cardiovascular Research
DOI 10.1016/j.cardiores.2006.02.025
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Abstract

While timely reperfusion of acute ischemic myocardium is essential for myocardial salvage, reperfusion results in a unique form of myocardial damage. Functional alterations occur, including depressed contractile function and decreased coronary flow as well as altered vascular reactivity. Both myocardial stunning and infarction are seen. Over the last two decades, it has become increasingly clear that oxidant and oxygen radical formation is greatly increased in the post-ischemic heart and serves as a critical central mechanism of post-ischemic injury. This oxidant formation is generated through a series of interacting pathways in cardiac myocytes and endothelial cells and triggers subsequent leukocyte chemotaxis and inflammation. Nitric oxide (NO) production and NO levels are also greatly increased in ischemic and post-ischemic myocardium, and this occurs through NO synthase (NOS)-dependent NO formation and NOS-independent nitrite reduction. Recently, it has been shown that the pathways of oxygen radical and NO generation interact and can modulate each other. Under conditions of oxidant stress, NOS can switch from NO to oxygen radical generation. Under ischemic conditions, xanthine oxidase can reduce nitrite to generate NO. NO and peroxynitrite can inhibit pathways of oxygen radical generation, and, in turn, oxidants can inhibit NO synthesis from NOS. Ischemic preconditioning markedly decreases NO and oxidant generation, and this appears to be an important mechanism contributing to preconditioning-induced myocardial protection.

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Metadata

Authors
ZWEIER, J., & TALUKDER, M.
Venue
Cardiovascular Research
Publisher
Oxford University Press (OUP)
Published
2006-05-01
Volume
70
Issue
2
Pages
181-190
ISSN
0008-6363 (ISSN-L)
DOI
10.1016/j.cardiores.2006.02.025
OpenAlex
W2137962262
Cited by
736
References
16
FWCI
21.66
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The role of oxidants and free radicals in reperfusion injury. https://app.cochat.ai/papers/10.1016/j.cardiores.2006.02.025
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ZWEIER, J., & TALUKDER, M. (2006). The role of oxidants and free radicals in reperfusion injury. Cardiovascular Research. https://doi.org/10.1016/j.cardiores.2006.02.025

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.