The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Oxygen Therapy in Suspected Acute Myocardial Infarction
Open accessAbstract
BACKGROUND: The clinical effect of routine oxygen therapy in patients with suspected acute myocardial infarction who do not have hypoxemia at baseline is uncertain. METHODS: In this registry-based randomized clinical trial, we used nationwide Swedish registries for patient enrollment and data collection. Patients with suspected myocardial infarction and an oxygen saturation of 90% or higher were randomly assigned to receive either supplemental oxygen (6 liters per minute for 6 to 12 hours, delivered through an open face mask) or ambient air. RESULTS: A total of 6629 patients were enrolled. The median duration of oxygen therapy was 11.6 hours, and the median oxygen saturation at the end of the treatment period was 99% among patients assigned to oxygen and 97% among patients assigned to ambient air. Hypoxemia developed in 62 patients (1.9%) in the oxygen group, as compared with 254 patients (7.7%) in the ambient-air group. The median of the highest troponin level during hospitalization was 946.5 ng per liter in the oxygen group and 983.0 ng per liter in the ambient-air group. The primary end point of death from any cause within 1 year after randomization occurred in 5.0% of patients (166 of 3311) assigned to oxygen and in 5.1% of patients (168 of 3318) assigned to ambient air (hazard ratio, 0.97; 95% confidence interval [CI], 0.79 to 1.21; P=0.80). Rehospitalization with myocardial infarction within 1 year occurred in 126 patients (3.8%) assigned to oxygen and in 111 patients (3.3%) assigned to ambient air (hazard ratio, 1.13; 95% CI, 0.88 to 1.46; P=0.33). The results were consistent across all predefined subgroups. CONCLUSIONS: Routine use of supplemental oxygen in patients with suspected myocardial infarction who did not have hypoxemia was not found to reduce 1-year all-cause mortality. (Funded by the Swedish Heart-Lung Foundation and others; DETO2X-AMI ClinicalTrials.gov number, NCT01787110 .).
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Roffi, M., Patrono, C., Collet, J.-P., Mueller, C., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv320 · Cited by 8,261
Self-citationThird universal definition of myocardial infarction
Thygesen, K., Alpert, J. S., Jaffe, A. S., Simoons, M. L., Chaitman, B. R., White, H. D., the Writing Group on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, Authors/Task Force Members Chairpersons, Thygesen, K., Alpert, J. S., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs184 · Cited by 3,058
Self-citationRegisters of the Swedish total population and their use in medical research
Ludvigsson, J. F., Almqvist, C., Bonamy, A.-K. E., Ljung, R., Michaëlsson, K., Neovius, M., Stephansson, O., & Ye, W. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0117-y · Cited by 1,674
Thrombus Aspiration during ST-Segment Elevation Myocardial Infarction
Fröbert, O., Lagerqvist, B., Olivecrona, G. K., Omerovic, E., Gudnason, T., Maeng, M., Aasa, M., Angerås, O., Calais, F., Danielewicz, M., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1308789 · Cited by 1,151
Self-citationJernberg, T., Attebring, M. F., Hambraeus, K., Ivert, T., James, S., Jeppsson, A., Lagerqvist, B., Lindahl, B., Stenestrand, U., & Wallentin, L. (2010) · Heart · doi:10.1136/hrt.2010.198804 · Cited by 773
Self-citationThe role of oxidants and free radicals in reperfusion injury
ZWEIER, J., & TALUKDER, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.02.025 · Cited by 736
Steg, P. G., Greenlaw, N., Tardif, J.-C., Tendera, M., Ford, I., Kääb, S., Abergel, H., Fox, K. M., Ferrari, R., & on behalf of the CLARIFY Registry Investigators (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs289 · Cited by 654
The Intention-to-Treat Principle: How to Assess the True Effect of Choosing a Medical Treatment
Detry, M. A., & Lewis, R. J. (2014) · JAMA · doi:10.1001/jama.2014.7523 · Cited by 634
Air Versus Oxygen in ST-Segment–Elevation Myocardial Infarction
Stub, D., Smith, K., Bernard, S., Nehme, Z., Stephenson, M., Bray, J. E., Cameron, P., Barger, B., Ellims, A. H., Taylor, A. J., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.014494 · Cited by 537
Schömig, A., Kastrati, A., Dirschinger, J., Mehilli, J., Schricke, U., Pache, J., Martinoff, S., Neumann, F.-J., & Schwaiger, M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008103430602 · Cited by 475
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2023 ESC Guidelines for the management of acute coronary syndromes
Byrne, R. A., Rossello, X., Coughlan, J. J., Barbato, E., Berry, C., Chieffo, A., Claeys, M. J., Dan, G.-A., Dweck, M. R., Galbraith, M., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad191 · Cited by 5,333
Self-citationChu, D. K., Kim, L. H.-Y., Young, P. J., Zamiri, N., Almenawer, S. A., Jaeschke, R., Szczeklik, W., Schünemann, H. J., Neary, J. D., & Alhazzani, W. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30479-3 · Cited by 778
Rao, S. V., O’Donoghue, M. L., Ruel, M., Rab, T., Tamis-Holland, J. E., Alexander, J. H., Baber, U., Baker, H., Cohen, M. G., Cruz-Ruiz, M., et al. (2025) · Circulation · doi:10.1161/cir.0000000000001309 · Cited by 625
Singer, M., Young, P. J., Laffey, J. G., Asfar, P., Taccone, F. S., Skrifvars, M. B., Meyhoff, C. S., & Radermacher, P. (2021) · Critical Care · doi:10.1186/s13054-021-03815-y · Cited by 282
Fordyce, C. B., Katz, J. N., Alviar, C. L., Arslanian-Engoren, C., Bohula, E. A., Geller, B. J., Hollenberg, S. M., Jentzer, J. C., Sims, D. B., Washam, J. B., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000909 · Cited by 116
Metadata
- Authors
- Hofmann, R., James, S. K., Jernberg, T., Lindahl, B., Erlinge, D., Witt, N., Arefalk, G., Frick, M., Alfredsson, J., Nilsson, L., Ravn-Fischer, A., Omerovic, E., Kellerth, T., Sparv, D., Ekelund, U., Linder, R., Ekström, M., Lauermann, J., Haaga, U., Pernow, J., Östlund, O., Herlitz, J., & Svensson, L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-09-28
- Volume
- 377
- Issue
- 13
- Pages
- 1240-1249
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2747404832
- Cited by
- 384
- References
- 16
- FWCI
- 29.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hofmann, R., James, S. K., Jernberg, T., Lindahl, B., Erlinge, D., Witt, N., Arefalk, G., Frick, M., Alfredsson, J., Nilsson, L., Ravn-Fischer, A., Omerovic, E., Kellerth, T., Sparv, D., Ekelund, U., Linder, R., Ekström, M., Lauermann, J., Haaga, U., . . . Svensson, L. (2017). Oxygen Therapy in Suspected Acute Myocardial Infarction. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1706222
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