Antioxidant Effects of Resveratrol in Cardiovascular, Cerebral and Metabolic Diseases
Abstract
Resveratrol-a natural polyphenolic compound-was first discovered in the 1940s. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. A large part of these effects are related to its antioxidant properties. Here we review: (a) the sources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and (d) the evidence for its efficacy and toxicity in humans. The overall aim of this review is to discuss the frontiers in the field of resveratrol's mechanisms, bioactivity, biology, and health-related use.
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As an antioxidant agent, RSV can scavenge free radicals and reduce ROS formation by inhibiting expression of NADPH and glycogen synthase kinase 3 beta proteins, and upregulating expression of antioxidant enzymes such as SOD2, CAT, GPx, and thioredoxin.
“As an antioxidant agent, RSV can scavenge free radicals and reduce ROS formation, by inhibiting the expression of NADPH and glycogen synthase kinase 3 beta proteins, and upregulating the expression of some antioxidant enzymes, such as SOD2, CAT, GPx, and thioredoxin [320,339,340].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [339]
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Self-citationPrevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes
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Metabolites and tissue distribution of resveratrol in the pig
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Antioxidant activity of resveratrol in red wine
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Potential Adverse Effects of Resveratrol: A Literature Review
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Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1
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Resveratrol primes the effects of physical activity in old mice
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Dose response biology of resveratrol in obesity
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- Authors
- Carrizzo, A., Forte, M., Damato, A., Trimarco, V., Salzano, F., Bartolo, M., Maciag, A., Puca, A. A., & Vecchione, C.
- Affiliations
- Istituto Neurologico Mediterraneo (IT)
- University of Naples Federico II (IT)
- University of Palermo (IT)
- MultiMedica (IT)
- University of Salerno (IT)
- Corresponding author
- Salzano, Francesco
- Vecchione, Carmine
- ORCID
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 61
- Pages
- 215-226
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2027139922
- Cited by
- 203
- References
- 185
- Citations by year
- 2026: 6 · 2025: 18 · 2024: 13 · 2023: 15 · 2022: 14 · 2021: 18 · 2020: 15 · 2019: 21 · 2018: 15 · 2017: 17 · 2016: 13 · 2015: 15 · 2014: 20 · 2013: 3
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- resveratrol, antioxidant activity, polyphenols, cardiovascular disease, cerebrovascular disease, metabolic disorders, diabetes mellitus, oxidative stress, redox signaling, bioavailability, neuroprotection
- MeSH terms
- Resveratrol, Antioxidants, Biological Availability, Cardiovascular Diseases, Cerebrovascular Disorders, Clinical Trials as Topic, Diabetes Mellitus, Humans, Metabolic Diseases, Oxidation-Reduction, Stilbenes, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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