Cited by 203Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesNatural Antidiabetic Agents Studies

Antioxidant Effects of Resveratrol in Cardiovascular, Cerebral and Metabolic Diseases

Carrizzo, Albino, Forte, Maurizio, Damato, Antonio, Trimarco, Valentina, Salzano, Francesco, Bartolo, Michelangelo, Maciag, Anna, Puca, Annibale A. +1 more·2013·Food and Chemical Toxicology

Abstract

Resveratrol-a natural polyphenolic compound-was first discovered in the 1940s. Although initially used for cancer therapy, it has shown beneficial effects against most cardiovascular and cerebrovascular diseases. A large part of these effects are related to its antioxidant properties. Here we review: (a) the sources, the metabolism, and the bioavailability of resveratrol; (b) the ability of resveratrol to modulate redox signalling and to interact with multiple molecular targets of diverse intracellular pathways; (c) its protective effects against oxidative damage in cardio-cerebro-vascular districts and metabolic disorders such as diabetes; and (d) the evidence for its efficacy and toxicity in humans. The overall aim of this review is to discuss the frontiers in the field of resveratrol's mechanisms, bioactivity, biology, and health-related use.

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Registry

Crossref · 10.1016/j.fct.2013.07.021

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185 of 185 references verified0 citation errors · 0 not checkable

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  • As an antioxidant agent, RSV can scavenge free radicals and reduce ROS formation by inhibiting expression of NADPH and glycogen synthase kinase 3 beta proteins, and upregulating expression of antioxidant enzymes such as SOD2, CAT, GPx, and thioredoxin.

    “As an antioxidant agent, RSV can scavenge free radicals and reduce ROS formation, by inhibiting the expression of NADPH and glycogen synthase kinase 3 beta proteins, and upregulating the expression of some antioxidant enzymes, such as SOD2, CAT, GPx, and thioredoxin [320,339,340].”

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Authors
Carrizzo, A., Forte, M., Damato, A., Trimarco, V., Salzano, F., Bartolo, M., Maciag, A., Puca, A. A., & Vecchione, C.
Affiliations
  • Istituto Neurologico Mediterraneo (IT)
  • University of Naples Federico II (IT)
  • University of Palermo (IT)
  • MultiMedica (IT)
  • University of Salerno (IT)
Corresponding author
  • Salzano, Francesco
  • Vecchione, Carmine
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2013-11
Volume
61
Pages
215-226
ISSN
0278-6915 (ISSN-L)
OpenAlex
W2027139922
Cited by
203
References
185
Citations by year
2026: 6 · 2025: 18 · 2024: 13 · 2023: 15 · 2022: 14 · 2021: 18 · 2020: 15 · 2019: 21 · 2018: 15 · 2017: 17 · 2016: 13 · 2015: 15 · 2014: 20 · 2013: 3
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
resveratrol, antioxidant activity, polyphenols, cardiovascular disease, cerebrovascular disease, metabolic disorders, diabetes mellitus, oxidative stress, redox signaling, bioavailability, neuroprotection
MeSH terms
Resveratrol, Antioxidants, Biological Availability, Cardiovascular Diseases, Cerebrovascular Disorders, Clinical Trials as Topic, Diabetes Mellitus, Humans, Metabolic Diseases, Oxidation-Reduction, Stilbenes, Oxidative Stress

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