The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Metabolic control of methylation and acetylation
Open accessAbstract
Methylation and acetylation of DNA and histone proteins are the chemical basis for epigenetics. From bacteria to humans, methylation and acetylation are sensitive to cellular metabolic status. Modification rates depend on the availability of one-carbon and two-carbon substrates (S-adenosylmethionine, acetyl-CoA, and in bacteria also acetyl-phosphate). In addition, they are sensitive to demodification enzyme cofactors (α-ketoglutarate, NAD+) and structural analog metabolites that function as epigenetic enzyme inhibitors (e.g., S-adenosylhomocysteine, 2-hydroxyglutarate). Methylation and acetylation likely initially evolved to tailor protein activities in microbes to their metabolic milieu. While the extracellular environment of mammals is more tightly controlled, the combined impact of nutrient abundance and metabolic enzyme expression impacts epigenetics in mammals sufficiently to drive important biological outcomes such as stem cell fate and cancer.
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1 retracted
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
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RetractedCancer-associated IDH1 mutations produce 2-hydroxyglutarate
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Self-citationIDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
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One-Carbon Metabolism in Health and Disease
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Self-citationMacrophage Immunometabolism: Where Are We (Going)?
Van den Bossche, J., O’Neill, L. A., & Menon, D. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.03.001 · Cited by 1,163
Metabolic Control of Longevity
López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753
Metabolism of Amino Acids in Cancer
Wei, Z., Liu, X., Cheng, C., Yu, W., & Yi, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.603837 · Cited by 429
Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation
Sivanand, S., Viney, I., & Wellen, K. E. (2018) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.11.004 · Cited by 357
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Metadata
- Authors
- Su, X., Wellen, K. E., & Rabinowitz, J. D.
- Venue
- Current Opinion in Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 30
- Pages
- 52-60
- ISSN
- 1367-5931 (ISSN-L)
- OpenAlex
- W2181681557
- Cited by
- 295
- References
- 24
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- green
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