Digital mental health interventions for depression
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One reason may be that as research in digital interventions matured, digital interventions focusing on depression began to examine explicitly their effects in the clinical treatment of depression.
“One reason may be that as research in digital interventions matured, digital interventions focusing on depression began to examine explicitly their effects in the clinical treatment of depression [80,81].”
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BackgroundDigital Mental Health Services: Moving From Promise to Results
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“9,34 However, challenges remain in ensuring the quality and depth of the therapeutic interaction in digital CBT, as well as addressing the needs of individuals who might require more intensive or personalized interventions.”
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“Currently, emotion monitoring and intervention measures based on smartphones can reduce the impact of psychological symptoms on the elderly including depression (Himle et al., 2022).”
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“To address this issue, digital interventions enable better and less burden-some integration of therapy content into the patients ’ daily lives (e.g., Himle et al., 2021).”
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“Investment in mental health DHIs is increasing, partly to improve access to care in overstretched health systems and partly due to emerging patient and user preference for DHI delivery of mental health care (4).”
BackgroundTechnology-Assisted, Group-Based CBT for Rural Adults’ Depression: Open Pilot Trial Results
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“Research has consistently shown that digital interventions can be effective for treating a variety of mental health conditions, including depression, anxiety, post-traumatic stress disorder (PTSD), and stress-related disorders [26].”
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“Concerns around the ability (or lack thereof) of DMHIs to provide the same support as face-toface treatment, tailor content to users unique needs, and respond to mental health crises also persist (6, 13).”
BackgroundBorghouts, J. W., Eikey, E. V., Leon, C. D., Schueller, S. M., Schneider, M. L., Stadnick, N. A., Zheng, K., Mukamel, D. B., & Sorkin, D. H. (2025) · JMIR Formative Research · doi:10.2196/73457 · Cited by 8 · see citing works
“Although these studies can demonstrate the potential and effectiveness of DMHIs [17,18], their effectiveness is ultimately related to their use, and previous studies researching mindfulness apps found a clear relationship between app use and improvements in mindfulness [6,19].”
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“Digital interventions that are empirically driven and incorporate elements of cognitive behavioral therapy are typically referred to as internet-based cognitive behavioral therapy (iCBT) [9].”
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“Given their low cost and resource constraints on in-person mental health services, DMHIs offer a scalable option for improving access to psychological support and therapies, potentially avoiding issues associated with stigma, as they can be personalised to individual needs [6,7].”
Nißen, M., Harperink, S., Joshi, P., Bischof, A. Y., Schachner, T., Lukic, Y. X., Schneider, F., Santhanam, P., von Wangenheim, F., Ollier, J., et al. (2025) · Journal of Medical Internet Research · doi:10.2196/67174 · Cited by 7 · see citing works
“The thematic coherence of a DHI can serve as a cognitive anchor , helping reduce distance and making it easier for users to relate to the intervention [56,57].”
Adjei-Boateng, D., & Ikoh, C. L. (2025) · Cureus · doi:10.7759/cureus.85943 · Cited by 6 · see citing works
“One of the most common frameworks used in digital interventions is CBT [14,31,32].”
Shen, Y., Wang, S. J., Lü, Y., Chen, K., Luo, L., & Hao, C. (2023) · Molecules · doi:10.3390/molecules28124620 · Cited by 5 · see citing works
Qu, D., Che, L., Chen, P., Zhu, A., Cai, T., Wu, Z., Li, W., Lin, J. A., Liu, B., Zhang, Q., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03467-w · Cited by 4 · see citing works
“Despite these positive effects, concerns remain regarding treatment adherence, with fi ve studies reporting adherence rates below 50% [9].”
Gao, L., Keller, F. M., Becker, P., Dahmen, A., & Lippke, S. (2023) · Journal of Medical Internet Research · doi:10.2196/43584 · Cited by 4 · see citing works
“High dropout rates were frequently reported in web-based studies, despite the convenience that digital use in the studies provided to both the research and participants [35,36].”
Editorial: Digital Interventions in Mental Health
Khanna, M. S., & Rose, R. D. (2021) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2021.06.013 · Cited by 4 · see citing works
Pinto, C., Brown, J., Hurt, C. S., Cubí‐Mollá, P., Chowdhury, S., McCracken, L. M., Norton, S., Volpato, R., Stumpf, S., & Bogosian, A. (2025) · Pilot and Feasibility Studies · doi:10.1186/s40814-025-01594-9 · Cited by 5 · see citing works
“As a response to the need for accessible, less resource-intensive interventions, the use of digital applications to provide mental health support has grown in recent years [13].”
Digital Interventions to Improve College and University Student Mental Health
Hensel, D. J. (2022) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2022.05.017 · Cited by 3 · see citing works
“[9] nor more broadly in the extant literature: while these models offer more accessible mental health care, how do we engage (and retain) young people in programs who lack computer/mobile devices or reliable internet, young people with hearing or vision challenges, or young people experience language barriers? [11] Mo…”
BackgroundUrban and Rural Differences in the Efficacy of a Mobile Health Depression Treatment for Young Adults
Mennis, J. L., Coatsworth, J. D., Russell, M. A., Zaharakis, N. M., Brown, A., & Mason, M. J. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21121572 · Cited by 2 · see citing works
“…cognitive behavioral therapy, an established, evidence-based approach to depression treatment, can be effectively delivered using digital platforms [9,10]. mHealth approaches for depression treatment are particularly appropriate for young adults, who have high usage of mobile phones and text…”
Lee, C., Joung, E., Koh, Y., Kim, E., Son, S., Kwon, S., & Lee, U. (2025) · Proceedings of the ACM on Human-Computer Interaction · doi:10.1145/3757533 · Cited by 2 · see citing works
“To address the issue of accessibility, various digital mental health interventions (DMHIs) using mobile applications and conversational agents have been actively developed for mental health care [42, 45, 115].”
Weaver, A., Rubyan, M. J., Holzworth, J., Hall, S. V., Ross, D., Felsman, P., Landry, C., Whitted, R., Long, B., Al-Shamari, T., et al. (2024) · Families in Society The Journal of Contemporary Social Services · doi:10.1177/10443894241281078 · Cited by 2 · see citing works
“CBT is effective when delivered by non-mental health professionals in their usual care settings (e.g., Anvari et al., 2023; Himle et al., 2014; Weaver et al., 2022; Zhang et al., 2019) and via technology (T-CBT; e.g., Andrews et al., 2018; Himle et al., 2022; Karyotaki et al., 2021).”
DARA: Development of a Chatbot Support System for an Anxiety Reduction Digital Intervention
Schwartz, R. X., Ramanan, A., Patel, D., Lynch, A., Baee, S., & Barnes, L. E. (2022) · Systems and Information Engineering Design Symposium · doi:10.1109/sieds55548.2022.9799419 · Cited by 2 · see citing works
Pinto, C., Norton, S., Cubi-Molla, P., Hurt, C., Chowdhury, S., Dooley, N., Safwi, A., Brown, J., Volpato, R., Stumpf, S., et al. (2025) · Aging & Mental Health · doi:10.1080/13607863.2025.2478508 · Cited by 1 · see citing works
“As a response to the need for accessible, less resource intensive interventions, the use of digital applications to provide mental health support has grown in recent years (Himle et al., 2022).”
HR PRACTICES ADDRESSING MENTAL HEALTH CHALLENGES AMONG GEN Z
Sugiharti, S., Kiswoyo, K., Abdullah, A., Sumiati, T., & Dwi, H. W. (2024) · International Conference of Business and Social Sciences · doi:10.24034/icobuss.v4i1.634 · Cited by 1 · see citing works
“Organizations may easily adopt digital mental health services to suit the mental health needs of Gen Z workers who are used to using technology for self-care and support (Lattie et al., 2019; Lipschitz et al., 2022; Himle et al., 2022).”
Emotional engagement and perceived empathy in live vs. automated psychological interviews
Nyman, T. J., Noromies, A.-K., Pompedda, F., Santtila, P. O., & Antfolk, J. (2025) · PLoS ONE · doi:10.1371/journal.pone.0323490 · Cited by 1 · see citing works
Driving User Engagement: A Mixed‐Method Marketing Approach for Digital Mental Health Intervention
Jena, R. K., Botella-Carrubí, D., & Móstoles, R. C. (2025) · Psychology and Marketing · doi:10.1002/mar.70060 · Cited by 1 · see citing works
Designing Resilient Educational Ecologies for Mental Health in Techno-Social Learning Environments
Alam, A. (2025) · IGI Global eBooks · doi:10.4018/979-8-3373-5007-3.ch001 · Cited by 1 · see citing works
Graziani, G., Aylward, B. S., Fung, V., & Kunkle, S. (2022) · Procedia Computer Science · doi:10.1016/j.procs.2022.09.096 · Cited by 1 · see citing works
“There has been a dramatic shift toward teletherapy and other virtual interventions as a scalable approach to increasing access to mental health care services and delivering evidence-supported therapy.[10] As face-to-face visits were restricted as a result of the pandemic, the full potential of these tools were now bei…”
BackgroundYapko, M. D. (2023) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2023.2199811 · Cited by 1 · see citing works
“Similarly, in the psychotherapy realm, new and varied approaches emerge as clinical researchers experiment with virtual reality, digital apps, computer programs, and delivery of treatments through telehealth (Bisby et al., 2022; Colombo et al., 2022; Himle et al., 2022; Scott et al., 2022).”
BackgroundBlaimschein, E. S. (2023) · Studies in health technology and informatics · doi:10.3233/shti230018 · Cited by 1 · see citing works
Transformative Effect of Virtual Reality and the Metaverse
Clara, L. D. (2023) · Advances in human and social aspects of technology book series · doi:10.4018/979-8-3693-0802-8.ch012 · Cited by 1 · see citing works
Choi, J., Kim, M., Kim, M. S., Fond, G. B., Boyer, L., Sánchez, G. F. L., Dragioti, E., Cortese, S., & Koyanagi, A. (2023) · Life Cycle · doi:10.54724/lc.2023.e18 · Cited by 1 · see citing works
“To note psychiatry consultations might be less accessible, interventions such as digital mental health service is required[32].”
BackgroundMennis, J. L., Coatsworth, J. D., Russell, M. A., Zaharakis, N. M., Brown, A., & Mason, M. J. (2024) · Annals of the American Association of Geographers · doi:10.1080/24694452.2024.2385395 · Cited by 1 · see citing works
“Health care delivered via digital technologies such as mobile phones (i.e., mHealth) might help meet the growing need for depression treatment (Himle et al. 2022).”
Børtveit, L., Nordgreen, T., & Nordahl‐Hansen, A. (2024) · Acta Psychologica · doi:10.1016/j.actpsy.2024.104510 · Cited by 1 · see citing works
Zainal, N. H., Rajendra, S. J., Doren, N. V., Salamanca-Sanabria, A., Curtiss, J. E., & Keng, S. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07372-4 · Cited by 2 · see citing works
“Theoretically, digital CBT options address mal-adaptive avoidant behaviors, negative self-talk patterns, and related action and thought repertoires via a pleth-ora of psychoeducational and emotion regulation (ER) skills [19].”
Weaver, A., Landry, C., Zhang, A., McQuown, L., Hahn, J., Harrington, M. M., Tucker, K. M., Holzworth, J., Buys, T., Smith, F. N., et al. (2022) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2022.100952 · Cited by 1 · see citing works
Borghouts, J. W., Eikey, E. V., Leon, C. D., Schueller, S. M., Schneider, M. L., Stadnick, N. A., Zheng, K., Mukamel, D. B., & Sorkin, D. H. (2023) · doi:10.2196/preprints.53161
Economic Evaluation of Mental Health Interventions
Jin, H., Jalali, A., Wijnen, B. F. M., & Bao, Y. (2023) · Frontiers research topics · doi:10.3389/978-2-8325-3692-6
Strategies to Mitigate Young Cancer Survivors with Depression
Brandon, R., & Zhang, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-32046-0_69-1
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Enhancing mental health services in higher education through digital technology
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Strategies to Mitigate Young Cancer Survivors with Depression
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“While numerous studies have demonstrated positive outcomes from mental health applications, particularly those offering structured therapeutic content such as cognitive behavioural therapy (CBT) [34, 35], the current study was observational only and did not aim to evaluate treatment effects.”
Reproducible workflow for online artificial intelligence in digital health
Ghosh, S., Gullapalli, B. T., Gao, D., Gazi, A., Trella, A. L., Xu, Z., Zhang, K., & Murphy, S. (2026) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2024.0607
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“Studies have shown that DMHIs can produce moderate improvements in symptoms of depression and anxiety [4] [5].”
Molfenter, T. D., Gustafson, D. H., Meng, L., Horst, J., Zhang, J., Fleddermann, K., & Kim, J. (2026) · doi:10.2196/preprints.115518
- Authors
- Himle, J. A., Weaver, A., Zhang, A., & Xiang, X.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Himle, Joseph A.
- Venue
- Cognitive and Behavioral Practice
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 29
- Issue
- 1
- Pages
- 50-59
- ISSN
- 1077-7229 (ISSN-L)
- OpenAlex
- W3129291866
- Cited by
- 65
- References
- 67
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 11 · 2023: 17 · 2022: 8 · 2021: 5
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Cognitive and Behavioral Practice (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- University of Michigan Library
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- digital mental health interventions, depression, cognitive behavioral therapy, treatment gap, digital therapeutics, clinical implementation barriers
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