Economic evaluations of internet- and mobile-based interventions for the treatment and prevention of depression: A systematic review

Paganini, Sarah; Teigelkötter, Wiebke; Buntrock, Claudia; Baumeister, Harald

doi:10.1016/j.jad.2017.07.018

Cited by 144Digital Mental Health InterventionsHealth Systems, Economic Evaluations, Quality of LifeMental Health Treatment and Access

Economic evaluations of internet- and mobile-based interventions for the treatment and prevention of depression: A systematic review

Paganini, Sarah, Teigelkötter, Wiebke, Buntrock, Claudia, Baumeister, Harald·2018·Journal of Affective Disorders

DOI 10.1016/j.jad.2017.07.018

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Abstract

Background Internet- and mobile-based interventions (IMIs) targeting depression have been shown to be clinically effective and are considered a cost-effective complement to established interventions. The aim of this review was to provide an overview of the evidence for the cost-effectiveness of IMIs for the treatment and prevention of depression.Methods A systematic database search was conducted (Medline, PsychInfo, CENTRAL, PSYNDEX, OHE HEED). Relevant articles were selected according to defined eligibility criteria. IMIs were classified as cost-effective if they were below a willingness-to-pay threshold (WTP) of €22,845 (£20,000) - €34,267 (£30,000) per additional quality-adjusted life year (QALY) according to the National Institute for Health and Clinical Excellence (NICE) standard. Study quality was assessed using the Consolidated Health Economic Evaluation Reporting Standard guidelines and the Cochrane Risk of Bias Tool.Results Of 1538 studies, seven economic evaluations of IMIs for the treatment of major depression, four for the treatment of subthreshold/minor depression and one for the prevention of depression. In six studies, IMIs were classified as likely to be cost-effective with an incremental cost-utility ratio between €3088 and €22,609. All of these IMIs were guided. Overall quality of most economic evaluations was evaluated as good. All studies showed some risk of bias.Limitations The studies used different methodologies and showed some risk of bias. These aspects as well as the classification of cost-effectiveness according to the WTP proposed by NICE should be considered when interpreting the results.Conclusions Results indicate that guided IMIs for the treatment of (subthreshold) depression have the potential to be a cost-effective complement to established interventions, but more methodologically sound studies are needed.

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IMIs have been shown to be effective and cost-effective across several mental health conditions.
“IMIs have been shown to be effective and cost-effective across several mental health conditions [10–14].”
From Impact of an acceptance facilitating intervention on psychotherapists' acceptance of blended therapy (2020) · cites this paper as [13]
A growing body of research supports the efficacy of Internet-based interventions for the treatment of depression.
“A growing body of research supports the efficacy of Internet-based interventions (IBIs) for the treatment of depression (17, 20–24).”
From Exploring the relationship between the acceptability of an internet-based intervention for depression in primary care and clinical outcomes: Secondary analysis of a randomized controlled trial (2019) · cites this paper as [23]
Emerging evidence supports the cost-effectiveness of guided digital mental health treatments.
“Emerging evidence supports the cost-effectiveness of guided DMHTs (20, 41).”
From Banbury forum consensus statement on the path forward for digital mental health treatment (2021) · cites this paper as [41]
DMHIs allow people to access psychotherapy skills and content in their own time and empower them to self-manage their symptoms.
“DMHIs allow people to access psychotherapy skills and content in their own time and empower them to self-manage their symptoms [7-11].”
From Needs and expectations for the myNewWay blended digital and face-to-face psychotherapy model of care for depression and anxiety (part 1): participatory design study including people with lived and living experience (2025) · cites this paper as [10]

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The EVIDENT-trial: protocol and rationale of a multicenter randomized controlled trial testing the effectiveness of an online-based psychological intervention
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Why Should Economic Evaluations of Medical Innovations Have a Societal Perspective?Preprint
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Effectiveness and cost-effectiveness of a guided Internet- and mobile-based intervention for the indicated prevention of major depression in patients with chronic back pain—study protocol of the PROD-BP multicenter pragmatic RCT
Sander, L., Paganini, S., Lin, J., Schlicker, S., Ebert, D. D., Buntrock, C., & Baumeister, H. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1193-6 · Cited by 44 · see citing works
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Web-based intervention for depressive symptoms in adults with types 1 and 2 diabetes mellitus: a health economic evaluation
Nobis, S., Ebert, D. D., Lehr, D., Smit, F., Buntrock, C., Berking, M., Baumeister, H., Snoek, F., Funk, B., & Riper, H. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2018.10 · Cited by 43 · see citing works
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Direct costs associated with depressive symptoms in late life: a 4.5-year prospective study
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Cost-effectiveness of online positive psychology: Randomized controlled trial
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Study protocol for a randomized, controlled, superiority trial comparing the clinical and cost- effectiveness of integrated online mental health assessment-referral-care in pregnancy to usual prenatal care on prenatal and postnatal mental health and infant health and development: the Integrated Maternal Psychosocial Assessment to Care Trial (IMPACT)
Kingston, D. E., Austin, M., Hegadoren, K., McDonald, S., Lasiuk, G. C., McDonald, S. D., Heaman, M. I., Biringer, A. B., Sword, W. A., Giallo, R., et al. (2014) · Trials · doi:10.1186/1745-6215-15-72 · Cited by 39 · see citing works
A web-based self-help intervention for partners of cancer patients based on Acceptance and Commitment Therapy: a protocol of a randomized controlled trial.
Köhle, N., Drossaert, C. H., Schreurs, K. M., Hagedoorn, M., Verdonck-de Leeuw, I. M., & Bohlmeijer, E. T. (2015) · BMC Public Health · doi:10.1186/s12889-015-1656-y · Cited by 38 · see citing works
Methoden der Kostenbestimmung in der gesundheitsökonomischen Evaluation
Krauth, C. (2010) · Gesundheitsökonomie & Qualitätsmanagement · doi:10.1055/s-0029-1245680 · Cited by 38 · see citing works
Implementation of Internet-based preventive interventions for depression and anxiety: role of support? The design of a randomized controlled trial
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The second Randomised Evaluation of the Effectiveness, cost-effectiveness and Acceptability of Computerised Therapy (REEACT-2) trial: does the provision of telephone support enhance the effectiveness of computer-delivered cognitive behaviour therapy? A randomised controlled trial.
Brabyn, S., Araya, R., Barkham, M., Bower, P., Cooper, C., Duarte, A., Kessler, D., Knowles, S. E., Lovell, K., Littlewood, E., et al. (2016) · Health Technology Assessment · doi:10.3310/hta20890 · Cited by 36 · see citing works
Cost-effectiveness of cognitive-behavioural therapy and drug interventions for major depression
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Absence of change in the gray matter volume of patients with ulcerative colitis in remission: a voxel based morphometry study
Agostini, A., Campieri, M., Bertani, A., Scarcelli, A., Ballotta, D., Calabrese, C., Rizzello, F., Gionchetti, P., Nichelli, P., & Benuzzi, F. (2015) · BioPsychoSocial Medicine · doi:10.1186/s13030-014-0028-7 · Cited by 35 · see citing works
Economic Evaluation of a Web-Based Guided Self-Help Intervention for Employees With Depressive Symptoms
Geraedts, A. S., van Dongen, J. M., Kleiboer, A. M., Wiezer, N. M., van Mechelen, W., Cuijpers, P. J., & Bosmans, J. E. (2015) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000000423 · Cited by 31 · see citing works
Economic evaluation of Internet-based problem-solving guided self-help treatment in comparison with enhanced usual care for depressed outpatients waiting for face-to-face treatment: A randomized controlled trial
Kolovos, S., Kenter, R. M. F., Bosmans, J. E., Beekman, A. T. F., Cuijpers, P. J., Kok, R. N., & van Straten, A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.025 · Cited by 29 · see citing works
Die Kosten der Depression und die Wirtschaftlichkeit ihrer Behandlung
König, H., Luppa, M., & Riedel-Heller, S. G. (2010) · Psychiatrische Praxis · doi:10.1055/s-0030-1248510 · Cited by 24 · see citing works
3 Die Berechnung von Kosten und Nutzen
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Internet-based treatment of major depression for patients on a waiting list for inpatient psychotherapy: protocol for a multi-centre randomised controlled trial
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Cost–effectiveness of preventive interventions for depressive disorders: an overview
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Low intensity vs. self-guided Internet-delivered psychotherapy for major depression: a multicenter, controlled, randomized study
del Hoyo, Y. L., Oliván‐Blázquez, B., Luciano, J. V., Mayoral, F., Roca, M., Gili, M., Andres, E. M., Serrano‐Blanco, A., Collazo, F., Araya, R., et al. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-21 · Cited by 22 · see citing works
Economic evaluation of healthcare interventions: old and new directions: Table 1:
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Supportive monitoring and disease management through the internet: An internet-delivered intervention strategy for recurrent depression
Kordy, H., Backenstraß, M., Hüsing, J., Wolf, M., Aulich, K., Bürgy, M., Puschner, B., Rummel‐Kluge, C., & Vedder, H. (2013) · Contemporary Clinical Trials · doi:10.1016/j.cct.2013.08.005 · Cited by 21 · see citing works
Internetbasierte psychologische Interventionen
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Prevention of depression in chronically physically ill adults
Kampling, H., Baumeister, H., Jäckel, W. H., & Mittag, O. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011246 · Cited by 19 · see citing works
Self-citation
Economic evidence for the clinical management of major depressive disorder: a systematic review and quality appraisal of economic evaluations alongside randomised controlled trials
Karyotaki, E., Tordrup, D., Buntrock, C., Bertollini, R., & Cuijpers, P. J. (2016) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796016000421 · Cited by 19 · see citing works
Self-citation
Die Berechnung von Kosten und Nutzen
Greiner, W. (2007) · Springer eBooks · doi:10.1007/978-3-540-49559-8_4 · Cited by 17 · see citing works
Quality assessment of economic evaluations of health promotion programs for children and adolescents—a systematic review using the example of physical activity
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What You Ask is What You Get: Willingness-to-Pay for a QALY in GermanyPreprint
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The (cost) effectiveness of an online intervention for pregnant women with affective symptoms: protocol of a randomised controlled trial
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2 Nutzentheoretische Lebensqualitätsmessung
Schöffski, O. (2011) · Springer eBooks · doi:10.1007/978-3-642-21700-5_13 · Cited by 6 · see citing works
How You Ask is What You Get: Willingness-to-Pay for a QALY in GermanyPreprint
Ahlert, M., Breyer, F., & Schwettmann, L. (2014) · SSRN Electronic Journal · doi:10.2139/ssrn.2456120 · Cited by 6 · see citing works
Ergebnisse zu Kosten und Nutzen der Psychotherapie
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Kein signifikanter Zusatznutzen als Add-on in der allgemeinärztlichen Routineversorgung
Baumeister, H. (2016) · InFo Neurologie + Psychiatrie · doi:10.1007/s15005-016-1601-3 · Cited by 2 · see citing works
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Digital interventions for the treatment of depression: a meta-analytic review
Moshe, I., Terhorst, Y., Philippi, P., Domhardt, M., Cuijpers, P., Cristea, I., Pulkki-Råback, L., Baumeister, H., & Sander, L. B. (2021) · Psychological Bulletin · doi:10.1037/bul0000334 · Cited by 390 · see citing works
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Internet Interventions for Adults with Anxiety and Mood Disorders: A Narrative Umbrella Review of Recent Meta-Analyses
Andersson, G., Carlbring, P., Titov, N., & Lindefors, N. (2019) · The Canadian Journal of Psychiatry · doi:10.1177/0706743719839381 · Cited by 324 · see citing works
A review of popular smartphone apps for depression and anxiety: Assessing the inclusion of evidence-based content
Wasil, A. R., Venturo-Conerly, K. E., Shingleton, R. M., & Weisz, J. R. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.103498 · Cited by 160 · see citing works
A pragmatic randomized waitlist-controlled effectiveness and cost-effectiveness trial of digital interventions for depression and anxiety
Richards, D., Enrique, A., Eilert, N., Franklin, M., Palacios, J., Duffy, D., Earley, C., Chapman, J., Jell, G., Sollesse, S., et al. (2020) · npj Digital Medicine · doi:10.1038/s41746-020-0293-8 · Cited by 154 · see citing works
Digital interventions in mental health: An overview and future perspectives
Löchner, J., Carlbring, P., Schuller, B. W., Torous, J. B., & Sander, L. (2025) · Internet Interventions · doi:10.1016/j.invent.2025.100824 · Cited by 170 · see citing works
Banbury forum consensus statement on the path forward for digital mental health treatment
Mohr, D. C., Azocar, F., Bertagnolli, A., Choudhury, T., Chrisp, P., Frank, R., Harbin, H., Histon, T., Kaysen, D., Nebeker, C., et al. (2021) · Psychiatric Services · doi:10.1176/appi.ps.202000561 · Cited by 115 · see citing works
e-Addictology: An Overview of New Technologies for Assessing and Intervening in Addictive Behaviors
Ferreri, F., Bourla, A., Mouchabac, S., & Karila, L. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00051 · Cited by 122 · see citing works
The effectiveness and cost-effectiveness of e-health interventions for depression and anxiety in primary care: a systematic review and meta-analysis
Massoudi, B., Holvast, F., Bockting, C. L. H., Burger, H., & Blanker, M. H. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.050 · Cited by 101 · see citing works
The use of technology for mental healthcare delivery among older adults with depressive symptoms: A systematic literature review
Harerimana, B., Forchuk, C., & O'Regan, T. (2019) · International Journal of Mental Health Nursing · doi:10.1111/inm.12571 · Cited by 109 · see citing works
The potential of predictive analytics to provide clinical decision support in depression treatment planning
Kessler, R. C. (2018) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000377 · Cited by 103 · see citing works
How to e-mental health: a guideline for researchers and practitioners using digital technology in the context of mental health
Seiferth, C., Vogel, L., Aas, B., Brandhorst, I., Carlbring, P., Conzelmann, A., Esfandiari, N., Finkbeiner, M., Hollmann, K., Lautenbacher, H., et al. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00085-1 · Cited by 99 · see citing works
Effectiveness of online psychological and psychoeducational interventions to prevent depression: Systematic review and meta-analysis of randomized controlled trials
Rigabert, A., Motrico, E., Moreno-Peral, P., Resurrección, D. M., Conejo-Cerón, S., Cuijpers, P., Martín-Gómez, C., López-Del-Hoyo, Y., & Bellón, J. Á. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101931 · Cited by 92 · see citing works
Internet- and mobile-based aftercare and relapse prevention in mental disorders: A systematic review and recommendations for future research
Hennemann, S., Farnsteiner, S., & Sander, L. (2018) · Internet Interventions · doi:10.1016/j.invent.2018.09.001 · Cited by 86 · see citing works
Economic evaluations of internet-based psychological interventions for anxiety disorders and depression: A systematic review
Mitchell, L. M., Joshi, U., Patel, V., Lu, C., & Naslund, J. A. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.01.092 · Cited by 80 · see citing works
Digital Interventions for Mental Disorders: Key Features, Efficacy, and Potential for Artificial Intelligence Applications
Ebert, D. D., Harrer, M., Apolinário-Hagen, J., & Baumeister, H. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-32-9721-0_29 · Cited by 76 · see citing works
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Internet-Delivered Cognitive Behavioural Therapy for Major Depression and Anxiety Disorders: A Health Technology Assessment.
(2019) · Europe PMC (PubMed Central) · Cited by 72 · see citing works
Cost-Effectiveness of Facilitated Access to a Self-Management Website, Compared to Usual Care, for Patients With Type 2 Diabetes (HeLP-Diabetes): Randomized Controlled Trial
Li, J., Parrott, S., Sweeting, M. J., Farmer, A. A., Ross, J., Dack, C., Pal, K., Yardley, L., Barnard, M., Hudda, M. T., et al. (2018) · Journal of Medical Internet Research · doi:10.2196/jmir.9256 · Cited by 72 · see citing works
Effectiveness of a Guided Web-Based Self-help Intervention to Prevent Depression in Patients With Persistent Back Pain: The PROD-BP Randomized Clinical Trial
Sander, L. B., Paganini, S., Terhorst, Y., Schlicker, S., Lin, J., Spanhel, K., Buntrock, C., Ebert, D. D., & Baumeister, H. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.1021 · Cited by 63 · see citing works
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Digital mental health interventions for depression
Himle, J. A., Weaver, A., Zhang, A., & Xiang, X. (2022) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2020.12.009 · Cited by 65 · see citing works
Systematic review of economic evaluations for internet- and mobile-based interventions for mental health problems
Kählke, F., Buntrock, C., Smit, F., & Ebert, D. D. (2022) · npj Digital Medicine · doi:10.1038/s41746-022-00702-w · Cited by 66 · see citing works
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Reboot Online: A Randomized Controlled Trial Comparing an Online Multidisciplinary Pain Management Program with Usual Care for Chronic Pain
Smith, J. S., Faux, S. G., Gardner, T., Hobbs, M. J., James, M., Joubert, A. E., Kladnitski, N., Newby, J. M., Schultz, R., Shiner, C. T., et al. (2019) · Pain Medicine · doi:10.1093/pm/pnz208 · Cited by 59 · see citing works
Effectiveness of a guided Internet- and Mobile-based intervention for patients with chronic back pain and depression (WARD-BP): a multicenter, pragmatic randomized controlled trial
Baumeister, H., Paganini, S., Sander, L. B., Lin, J., Schlicker, S., Terhorst, Y., Moshagen, M., Bengel, J., Lehr, D., & Ebert, D. D. (2021) · Psychotherapy and Psychosomatics · doi:10.1159/000511881 · Cited by 55 · see citing works
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Efficacy of a Guided Web-Based Self-Management Intervention for Depression or Dysthymia: Randomized Controlled Trial With a 12-Month Follow-Up Using an Active Control Condition
Oehler, C., Görges, F., Rogalla, M., Rummel‐Kluge, C., & Hegerl, U. (2020) · Journal of Medical Internet Research · doi:10.2196/15361 · Cited by 56 · see citing works
Impact of an acceptance facilitating intervention on psychotherapists' acceptance of blended therapy
Baumeister, H., Terhorst, Y., Grässle, C., Freudenstein, M., Nübling, R., & Ebert, D. D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236995 · Cited by 53 · see citing works
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Internet-Based Interventions in Chronic Somatic Disease
Bendig, E., Bauereiß, N., Ebert, D. D., Snoek, F., Andersson, G., & Baumeister, H. (2018) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2018.0659 · Cited by 54 · see citing works
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Digital interventions in mental health: Evidence syntheses and economic modelling
Gega, L., Jankovic, D., Saramago, P., Marshall, D., Dawson, S., Brabyn, S., Nikolaidis, G. F., Melton, H., Churchill, R., & Bojke, L. (2022) · Health Technology Assessment · doi:10.3310/rcti6942 · Cited by 48 · see citing works
mHealth applications: potentials, limitations, current quality and future directions
Messner, E.-M., Probst, T., O’Rourke, T., Stoyanov, S., & Baumeister, H. (2019) · Studies in neuroscience, psychology and behavioral economics · doi:10.1007/978-3-030-31620-4_15 · Cited by 49 · see citing works
The efficacy of self-guided internet and mobile-based interventions for preventing anxiety and depression–A systematic review and meta-analysis
Edge, D., Watkins, E. R., Limond, J., & Mugadza, J. (2023) · Behaviour Research and Therapy · doi:10.1016/j.brat.2023.104292 · Cited by 42 · see citing works
Cost–Utility of Internet-Based Cognitive Behavioral Therapy in Unipolar Depression: A Markov Model Simulation
Baumann, M., Stargardt, T., & Frey, S. (2020) · Applied Health Economics and Health Policy · doi:10.1007/s40258-019-00551-x · Cited by 38 · see citing works
Effectiveness and cost-effectiveness of guided Internet- and mobile-based CBT for adolescents and young adults with chronic somatic conditions and comorbid depression and anxiety symptoms (youthCOACHCD): study protocol for a multicentre randomized controlled trial
COACH consortium, Lunkenheimer, F., Domhardt, M., Geirhos, A., Kilian, R., Mueller-Stierlin, A. S., Holl, R. W., Meissner, T., Minden, K., Moshagen, M., et al. (2020) · Trials · doi:10.1186/s13063-019-4041-9 · Cited by 37 · see citing works
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Effectiveness of an internet-based intervention for procrastination in college students (StudiCare Procrastination): Study protocol of a randomized controlled trial
Küchler, A.-M., Albus, P., Ebert, D., & Baumeister, H. (2019) · Internet Interventions · doi:10.1016/j.invent.2019.100245 · Cited by 34 · see citing works
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Efficacy of Three Low-Intensity, Internet-Based Psychological Interventions for the Treatment of Depression in Primary Care: Randomized Controlled Trial
Gili, M., Castro, A., García‐Palacios, A., García‐Campayo, J., Mayoral, F., Botella, C., Roca, M., Barceló‐Soler, A., Hurtado, M. M., Navarro, M., et al. (2020) · Journal of Medical Internet Research · doi:10.2196/15845 · Cited by 36 · see citing works
Economic evaluations of public health interventions for physical activity and healthy diet: A systematic review
Gebreslassie, M., Sampaio, F., Nystrand, C., Ssegonja, R., & Feldman, I. (2020) · Preventive Medicine · doi:10.1016/j.ypmed.2020.106100 · Cited by 36 · see citing works
Systematic review and critique of methods for economic evaluation of digital mental health interventions
Jankovic, D., Bojke, L., Marshall, D., Saramago Goncalves, P., Churchill, R., Melton, H., Brabyn, S., & Gega, L. (2021) · Applied Health Economics and Health Policy · doi:10.1007/s40258-020-00607-3 · Cited by 36 · see citing works
Exploring the relationship between the acceptability of an internet-based intervention for depression in primary care and clinical outcomes: Secondary analysis of a randomized controlled trial
Mira, A., Soler, C., Alda, M., Baños, R., Castilla, D., Castro, A., García-Campayo, J., García-Palacios, A., Gili, M., Hurtado, M., et al. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00325 · Cited by 29 · see citing works
Outcomes of Best-Practice Guided Digital Mental Health Interventions for Youth and Young Adults with Emerging Symptoms: Part I. A Systematic Review of Socioemotional Outcomes and Recommendations
Opie, J. E., Vuong, A. T., Welsh, E. T., Gray, R. J., Pearce, N., Marchionda, S., Mutch, R., & Khalil, H. (2024) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-024-00469-4 · Cited by 35 · see citing works
Is Digital Treatment the Holy Grail? Literature Review on Computerized and Blended Treatment for Depressive Disorders in Youth
Rasing, S. P. A., Stikkelbroek, Y. A. J., & Bodden, D. H. M. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17010153 · Cited by 33 · see citing works
A guided and unguided internet- and mobile-based intervention for chronic pain: health economic evaluation alongside a randomised controlled trial
Paganini, S., Lin, J., Kählke, F., Buntrock, C., Leiding, D., Ebert, D. D., & Baumeister, H. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-023390 · Cited by 31 · see citing works
Economic Evaluation of an Internet-Based Preventive Cognitive Therapy With Minimal Therapist Support for Recurrent Depression: Randomized Controlled Trial
Klein, N. S., Bockting, C., Wijnen, B. F. M., Kok, G. D., van Valen, E., Riper, H. M., Cuijpers, P. J., Dekker, J., van der Heiden, C., Burger, H., et al. (2018) · Journal of Medical Internet Research · doi:10.2196/10437 · Cited by 29 · see citing works
Predictors of dropout in a digital intervention for the prevention and treatment of depression in patients with chronic Back pain: secondary analysis of two randomized controlled trials
Moshe, I., Terhorst, Y., Paganini, S., Schlicker, S., Pulkki-Råback, L., Baumeister, H., Sander, L. B., & Ebert, D. D. (2022) · Journal of Medical Internet Research · doi:10.2196/38261 · Cited by 28 · see citing works
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Guided Internet-Based Cognitive Behavioral Therapy for Depression: Implementation Cost-Effectiveness Study
Piera-Jiménez, J., Etzelmueller, A., Kolovos, S., Folkvord, F., & Lupiáñez‐Villanueva, F. (2021) · Journal of Medical Internet Research · doi:10.2196/27410 · Cited by 25 · see citing works
Economic Evaluations of Public Health Interventions to Improve Mental Health and Prevent Suicidal Thoughts and Behaviours: A Systematic Literature Review
Feldman, I., Gebreslassie, M., Sampaio, F., Nystrand, C., & Ssegonja, R. (2020) · Administration and Policy in Mental Health and Mental Health Services Research · doi:10.1007/s10488-020-01072-9 · Cited by 24 · see citing works
Health economic evaluation of an internet intervention for depression (deprexis), a randomized controlled trial
Gräfe, V., Moritz, S., & Greiner, W. (2020) · Health Economics Review · doi:10.1186/s13561-020-00273-0 · Cited by 22 · see citing works
Guided Internet-Based Cognitive Behavioral Therapy for Insomnia: Health-Economic Evaluation From the Societal and Public Health Care Perspective Alongside a Randomized Controlled Trial
Buntrock, C., Lehr, D., Smit, F., Horvath, H., Berking, M., Spiegelhalder, K., Riper, H. M., & Ebert, D. D. (2021) · Journal of Medical Internet Research · doi:10.2196/25609 · Cited by 22 · see citing works
Self-citation
User-Centered Design of a Gamified Mental Health App for Adolescents in Sub-Saharan Africa: Multicycle Usability Testing Study
Pozuelo, J. R., Moffett, B., Davis, M., Stein, A. L., Cohen, H., Craske, M. G., Maritze, M., Makhubela, P., Nabulumba, C., Sikoti, D., et al. (2023) · JMIR Formative Research · doi:10.2196/51423 · Cited by 22 · see citing works
From e-Health to i-Health: Prospective Reflexions on the Use of Intelligent Systems in Mental Health Care
Briffault, X., Morgiève, M., & Courtet, P. (2018) · Brain Sciences · doi:10.3390/brainsci8060098 · Cited by 21 · see citing works
Transdiagnostic Tailored Internet- and Mobile-Based Guided Treatment for Major Depressive Disorder and Comorbid Anxiety: Study Protocol of a Randomized Controlled Trial
Weisel, K. K., Zarski, A., Berger, T., Schaub, M. P., Krieger, T., Moser, C. T., Berking, M., & Ebert, D. D. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00274 · Cited by 21 · see citing works
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Authors: Paganini, S., Teigelkötter, W., Buntrock, C., & Baumeister, H.
Affiliations: University of Freiburg (DE)
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Universität Ulm (DE)
Corresponding author: Paganini, Sarah
ORCID: Paganini, Sarah
Buntrock, Claudia
Baumeister, Harald
Venue: Journal of Affective Disorders
Publisher: Elsevier BV
Published: 2018-01
Volume: 225
Pages: 733-755
ISSN: 0165-0327 (ISSN-L)
DOI: 10.1016/j.jad.2017.07.018
OpenAlex: W2735986931
Cited by: 144
References: 113
Citations by year: 2026: 5 · 2025: 11 · 2024: 11 · 2023: 18 · 2022: 22 · 2021: 19 · 2020: 23 · 2019: 21 · 2018: 13 · 2017: 1
FWCI: 1.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Affective Disorders (publishedVersion)
PubMed (publishedVersion)
Funders: Bundesministerium für Bildung und Forschung (01GY1330A)
Topics: Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords: online intervention, mobile-based interventions, depression treatment, depression prevention, cost-effectiveness, major depressive disorder, subthreshold depression, minor depression, guided intervention, quality-adjusted life years, willingness-to-pay threshold, risk of bias
MeSH terms: Cost-Benefit Analysis, Depression, Major Depressive Disorder, Humans, Magnetic Resonance Imaging, Treatment Outcome, Quality-Adjusted Life Years, Internet

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Economic evaluations of internet- and mobile-based interventions for the treatment and prevention of depression: A systematic review

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