Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin–angiotensin system
Abstract
Background Antihypertensive and tissue-protective properties of vitamin D metabolites are increasingly attributed to the inhibition of renin synthesis by 1,25-dihydroxyvitamin D [1,25(OH)2D] in the kidney. Method We aimed to document a potential association between 25-hydroxyvitamin D [25(OH)D], 1,25(OH)2D and the circulating renin-angiotensin system (RAS) in a large cohort of patients referred (n=3316) to coronary angiography. Results Of the 3316 subjects, 3296 (median age: 63.5 (56.3-70.6)years; 30.2% women) had a baseline measurement of 25(OH)D [median: 15.6(10.1-23.0)microg/L)], 1,25(OH)2D [median: 33.2(25.2-42.9)pg/mL], plasma renin concentration [PRC; median: 11.4(6.0-24.6)pg/mL] and angiotensin 2 [median: 20.0(12.0-35.0)ng/L]. Multivariate adjusted ANCOVA showed a steady increase of PRC values across declining deciles of 25(OH)D and 1,25(OH)2D values (P=0.013 and P=0.045), respectively. Additionally, mean angiotensin 2 values increased significantly across decreasing 25(OH)D and 1,25(OH)2D values (P=0.020 and P=0.024, respectively). In contrast, multivariate adjusted ANCOVA revealed no significant associations between aldosterone, aldosterone-to-renin ratio and 25(OH)D/1,25(OH)2D values. In multivariate stepwise regression analyses both, 25(OH)D and 1,25(OH)2D emerged as independent predictors of plasma renin and angiotensin 2 concentrations. Conclusions Our data showed for the first time in humans that both, lower 25(OH)D and 1,25(OH)2D values are independently related to an upregulated circulating RAS.
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Parameters for Eq. 2.20 were chosen based on data from Tomaschitz et al. [41] relating calcitriol levels with renin concentration.
“The parameters were chosen (listed in Table 2.2) based on the data from Tomaschitz et al. [41] that related calcitriol levels with renin concentration.”
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“To model inhibition of R sec by calcitriol we let: (2.20) The parameters were chosen (listed in Table 2.2) based on the data from Tomaschitz et al. [41] that related calcitriol levels with renin concentration.”
Influential
- Authors
- Tomaschitz, A., Pilz, S., Ritz, E., Grammer, T., Drechsler, C., Boehm, B. O., & März, W.
- Affiliations
- Medical University of Graz (AT)
- Heidelberg University (DE)
- Synlab (Germany) (DE)
- University of Würzburg (DE)
- University Hospital Ulm (DE)
- Corresponding author
- Tomaschitz, Andreas
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 411
- Issue
- 17-18
- Pages
- 1354-1360
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W115572501
- Cited by
- 246
- References
- 1
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 14 · 2022: 17 · 2021: 14 · 2020: 17 · 2019: 11 · 2018: 13 · 2017: 18 · 2016: 15 · 2015: 22 · 2014: 21 · 2013: 28 · 2012: 17
- FWCI
- 14.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D, renin-angiotensin system, plasma renin concentration, angiotensin II, vitamin D deficiency, coronary angiography patients, aldosterone, aldosterone-renin ratio, renin inhibition, hypertension, vitamin D supplementation
- MeSH terms
- Aged, Analysis of Variance, Female, Humans, Male, Middle Aged, Prospective Studies, Renin-Angiotensin System, Risk Factors, Vitamin D
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