CoChat
Sign Up
Cited by 47

The DOI matches its Crossref record.

Emerging role of Insig-1 in lipid metabolism and lipid disorders

Ouyang, Shuhui, Mo, Zhongcheng, Sun, Sha, Yin, Kai, Lv, Yuncheng·2020·Clinica Chimica Acta
DOI 10.1016/j.cca.2020.05.042
Open this paper in CoChat — free account

Abstract

Growing evidence has demonstrated that Insig-1 is intricately involved in lipid metabolism regulation and the progression of lipid disorders. Our review summarizes updated information on the role and underlying mechanisms of Insig-1 in lipid metabolism dyshomeostasis and lipid disorders. As a member of the insulin-induced gene family, insulin-induced gene 1 (Insig-1) is a six-span transmembrane protein embedded in the endoplasmic reticulum (ER) membrane. Insig-1 is widely involved in the maintenance of intracellular lipid metabolism homeostasis by controlling the activation of sterol regulatory element-binding proteins (SREBPs) and the degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR). Growing experimental and clinical data have identified that Insig-1 reduces lipid accumulation in hepatocytes to relieve the development of nonalcoholic fatty liver disease (NAFLD), downregulates the plasma level of free cholesterol and protects β cells against lipotoxicity to alleviate diabetic dyslipidemia. In addition, Insig-1 suppresses adipogenesis and inhibits the differentiation of preadipocytes to prevent the occurrence of obesity. Insig-1 is a key regulatory factor that maintains intracellular lipid metabolism homeostasis and is a promising therapeutic target for lipid disorders.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.cca.2020.05.042

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 46

  1. Romani, 2019, Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP, Nat. Cell. Biol., 21, 338, 10.1038/s41556-018-0270-5 · DOI
  2. Gill, 2011, Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase, Cell. Metab., 13, 260, 10.1016/j.cmet.2011.01.015 · DOI · Paper page
  3. Gwang-woong, 2012, Low-density lipoprotein receptor (LdLr) family orchestrates cholesterol homeostasis, J. Biol. Med., 85, 19
  4. Yang, 2019, Scavenger receptor class B type I (SR-BI) in ruditapes philippinarum: A versatile receptor with multiple functions, Fish. Shellfish. Immu., 88, 328, 10.1016/j.fsi.2019.03.009 · DOI
  5. Hopfner, 2016, Invited review: Architectures and mechanisms of ATP binding cassette proteins, Biopolymers, 105, 492, 10.1002/bip.22843 · DOI
  6. Samovski, 2019, Regulation of lipophagy in NAFLD by cellular metabolism and CD36, J. Lipid. Res., 60, 755, 10.1194/jlr.C093674 · DOI
  7. Goldberg, 2001, Clinical reverw 124 diabetic dyslipidemia: causes and consequences, J. Clin. Endocr. Metab., 86, 965, 10.1210/jcem.86.3.7304 · DOI
  8. Henao-Mejia, 2012, Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity, Nature, 482, 179, 10.1038/nature10809 · DOI · Paper page
  9. Diamond, 1993, Novel delayed-early and highly insulin-induced growth response genes, J. Biol. Chem., 268, 15185, 10.1016/S0021-9258(18)82454-1 · DOI · Paper page
  10. Takaishi, 2004, Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese zucker diabetic fatty rats and in fasted/refed normal rats, P. Natl. Acad. Sci. USA, 101, 7106, 10.1073/pnas.0401715101 · DOI
  11. Li, 2002, Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity, Am. J. Physiol-Endocr. M., 282, 1334
  12. Carobbio, 2013, Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity, Diabetes., 62, 3697, 10.2337/db12-1748 · DOI
  13. Sever, 2003, Accelerated degradation of HMG CoA reductase mediated by binding of Insig-1 to its sterol-sensing domain, Mol. Cell., 11, 25, 10.1016/S1097-2765(02)00822-5 · DOI
  14. Yang, 2002, Crucial Step in Cholesterol Homeostasis, Cell, 110, 489, 10.1016/S0092-8674(02)00872-3 · DOI · Paper page
  15. Burg, 2008, Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast, Cell. Metab., 8, 522, 10.1016/j.cmet.2008.09.004 · DOI
  16. Peng, 1997, Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene, Genomic, 43, 278, 10.1006/geno.1997.4821 · DOI
  17. Wu, 2014, Isolation, sequence characterization, and tissue transcription profiles of two novel buffalo genes: INSIG1 and INSIG2, Trop. Anim. Health. Pro., 46, 33, 10.1007/s11250-013-0443-y · DOI
  18. Feramisco, 2004, Membrane topology of human insig-1, a protein regulator of lipid synthesis, J. Biol. Chem., 279, 8487, 10.1074/jbc.M312623200 · DOI
  19. Gong, 2006, Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis, P. Natl. Acad. Sci. USA, 103, 6154, 10.1073/pnas.0601923103 · DOI
  20. Dong, 2010, Insulin-induced gene: a new regulator in lipid metabolism, Peptides., 31, 2145, 10.1016/j.peptides.2010.07.020 · DOI
  21. Espenshade, 2007, Regulation of sterol synthesis in eukaryotes, Annu. Rev. Genet., 41, 401, 10.1146/annurev.genet.41.110306.130315 · DOI · Paper page
  22. Attie, 2004, Insig: a significant integrator of nutrient and hormonal signals, J. Clin. Invest., 113, 1112, 10.1172/JCI21450 · DOI
  23. Engelking, 2005, Schoenheimer effect explained–feedback regulation of cholesterol synthesis in mice mediated by Insig proteins, J. Clin. Invest., 115, 2489, 10.1172/JCI25614 · DOI · Paper page
  24. Nguyen, 2009, Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells, J. Biol. Chem., 284, 26778, 10.1074/jbc.M109.032342 · DOI
  25. Chen, 2011, Overexpression of Insig-1 protects beta cell against glucolipotoxicity via SREBP-1c, J. Biomed. Sci., 18, 57, 10.1186/1423-0127-18-57 · DOI
  26. Qin, 2008, Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice, Hepatology, 48, 432, 10.1002/hep.22334 · DOI
  27. Li, 2019, Insulin-induced gene 1 and 2 isoforms synergistically regulate triacylglycerol accumulation, lipid droplet formation, and lipogenic gene expression in goat mammary epithelial cells, J. Dairy. Sci., 102, 1736, 10.3168/jds.2018-15492 · DOI
  28. Engelking, 2004, Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis, J. Clin. Invest., 113, 1168, 10.1172/JCI20978 · DOI · Paper page
  29. Tao, 2019, Investigation of the association between obesity and Insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China, Biosci. Rep., 23, 1
  30. Xu, 2016, Overexpression of SREBP1 (sterol regulatory element binding protein 1) promotes de novo fatty acid synthesis and triacylglycerol accumulation in goat mammary epithelial cells, J. Dairy. Sci., 99, 783, 10.3168/jds.2015-9736 · DOI
  31. Radhakrishnan, 2007, Sterol-regulated transport of SREBPs from endoplasmic reticulum to golgi: oxysterols block transport by binding to Insig, P. Natl. Acad. Sci. USA, 104, 6511, 10.1073/pnas.0700899104 · DOI · Paper page
  32. Le, 2019, Increased hepatic INSIG-SCAP-SREBP expression is associated with cholesterol metabolism disorder in assisted reproductive technology-conceived aged mice, Reprod. Toxicol., 84, 9, 10.1016/j.reprotox.2018.12.003 · DOI
  33. Adams, 2003, Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles, P. Natl. Acad. Sci. USA, 100, 10647, 10.1073/pnas.1534833100 · DOI
  34. Sun, 2005, Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro, J. Biol. Chem., 280, 26483, 10.1074/jbc.M504041200 · DOI · Paper page
  35. McPherson, 2004, Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis, Biochem. Cell. biol., 82, 201, 10.1139/o03-090 · DOI
  36. Lee, 2006, Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines, P. Natl. Acad. Sci. USA, 103, 4958, 10.1073/pnas.0600422103 · DOI
  37. Wiest, 2013, The increasingly complex mechanism of HMG-CoA reductase, Accounts. Chem. Res., 46, 2416, 10.1021/ar3003267 · DOI
  38. Lee, 2007, Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation, J. Lipid. Res., 48, 318, 10.1194/jlr.M600476-JLR200 · DOI
  39. Eberle, 2004, SREBP transcription factors: master regulators of lipid homeostasis, Biochimie., 86, 839, 10.1016/j.biochi.2004.09.018 · DOI
  40. Russo, 2016, Plasma triglycerides and HDL-C levels predict the development of diabetic kidney disease in subjects with type 2 diabetes: The AMDAnnals Initiative, Diabetes. Care., 39, 2278, 10.2337/dc16-1246 · DOI
  41. Liu, 2012, Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis, Cell. Metab., 16, 213, 10.1016/j.cmet.2012.06.014 · DOI · Paper page
  42. Smith, 2010, INSIG1 influences obesity-related hypertriglyceridemia in humans, J. Lipid. Res., 51, 701, 10.1194/jlr.M001404 · DOI
  43. Arner, 2019, Adipose lipid turnover and long-term changes in body weight, Nat. Med., 25, 1385, 10.1038/s41591-019-0565-5 · DOI
  44. Li, 2003, Insig-1 “brakes” lipogenesis in adipocytes and inhibits differentiation of preadipocytes, P. Natl. Acad. Sci. USA, 100, 9476, 10.1073/pnas.1133426100 · DOI
  45. Ka, 2009, Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway, Int. J. Mol. Med., 23, 633
  46. Wu, 2017, An investigation of obesity susceptibility genes in Northern Han Chinese by targeted resequencing, Medicine., 96, 6117, 10.1097/MD.0000000000006117 · DOI

Cited by

Sorted by citations

See all 47

Metadata

Authors
Ouyang, S., Mo, Z., Sun, S., Yin, K., & Lv, Y.
ORCID
Ouyang, Shuhui
Venue
Clinica Chimica Acta
Publisher
Elsevier BV
Published
2020-09
Volume
508
Pages
206-212
ISSN
0009-8981
DOI
10.1016/j.cca.2020.05.042
Cited by
47
References
0
Language
en
Licence
Funders
National Natural Science Foundation of China

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review