The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis
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INSIG1 is a protein promoting ER retention of SREBPs, and it is the targeted gene that exerts negative feedback control of SREBPs.
“INSIG1 is a protein promoting ER retention of SREBPs, while it is the targeted gene that exerts negative feedback control of SREBPs (35, 36).”
From Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression (2021) · cites this paper as [35]
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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Self-citationDiet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors
Yokode, M., Hammer, R. E., Ishibashi, S., Brown, M. S., & Goldstein, J. L. (1990) · Science · doi:10.1126/science.2244210 · Cited by 175
Self-citationJanowski, B. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202471599 · Cited by 79
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- 10.1016/S1097-2765(02)00822-5 · DOI
- 10.1074/jbc.M310053200 · DOI
- 10.1016/S0092-8674(02)00872-3 · DOI · Paper page
- 10.1073/pnas.162488899 · DOI · Paper page
- 10.1073/pnas.1534923100 · DOI · Paper page
- 10.1074/jbc.M312623200 · DOI
- 10.1073/pnas.0130116100 · DOI
- 10.1073/pnas.1534833100 · DOI
- 10.1074/jbc.M306476200 · DOI
- Simonet, 1993, J. Biol. Chem., 268, 8221, 10.1016/S0021-9258(18)53085-4 · DOI
- 10.1101/gad.844900 · DOI
- 10.1073/pnas.98.4.1477 · DOI · Paper page
- 10.1126/science.290.5497.1771 · DOI
- 10.1016/S1097-2765(00)00009-5 · DOI
- 10.1101/gad.891301 · DOI · Paper page
- 10.1073/pnas.201524598 · DOI · Paper page
- 10.1172/JCI119746 · DOI · Paper page
- Allan, 1996, J. Lipid Res., 37, 1510, 10.1016/S0022-2275(20)39135-5 · DOI
- 10.1172/JCI118951 · DOI
- 10.1074/jbc.M111421200 · DOI · Paper page
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Regulation of Sterol Synthesis in Eukaryotes
Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593
Kim, C.-W., Addy, C., Kusunoki, J., Anderson, N. N., Deja, S., Fu, X., Burgess, S. C., Li, C., Ruddy, M., Chakravarthy, M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.009 · Cited by 419
Self-citationPnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
Smagris, E., BasuRay, S., Li, J., Huang, Y., Lai, K. V., Gromada, J., Cohen, J. C., & Hobbs, H. H. (2015) · Hepatology · doi:10.1002/hep.27242 · Cited by 379
Moon, Y.-A., Liang, G., Xie, X., Frank-Kamenetsky, M., Fitzgerald, K., Koteliansky, V., Brown, M. S., Goldstein, J. L., & Horton, J. D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.017 · Cited by 320
Self-citationBasuRay, S., Smagris, E., Cohen, J. C., & Hobbs, H. H. (2017) · Hepatology · doi:10.1002/hep.29273 · Cited by 302
Smagris, E., Gilyard, S., BasuRay, S., Cohen, J. C., & Hobbs, H. H. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.719955 · Cited by 226
Yoon, J. Y., Kwon, H. H., Min, S. U., Thiboutot, D. M., & Suh, D. H. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.292 · Cited by 183
Kim, C.-W., Moon, Y.-A., Park, S. W., Cheng, D., Kwon, H. J., & Horton, J. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001292107 · Cited by 136
Self-citationIdentification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia
Zhang, Y., Yin, L., Anderson, J., Ma, H., Gonzalez, F. J., Willson, T. M., & Edwards, P. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.083899 · Cited by 112
Cazanave, S., Podtelezhnikov, A., Jensen, K., Seneshaw, M., Kumar, D. P., Min, H.-K., Santhekadur, P. K., Banini, B., Mauro, A. G., M. Oseini, A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17370-6 · Cited by 66
Azzu, V., Vacca, M., Kamzolas, I., Hall, Z., Leslie, J., Carobbio, S., Virtue, S., Davies, S. E., Lukasik, A., Dale, M., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101210 · Cited by 52
Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression
Xu, Y., Tao, J., Yu, X., Wu, Y., Chen, Y., You, K., Zhang, J., Getachew, A., Pan, T., Zhuang, Y., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.147038 · Cited by 45
Zhang, Z.-H., Liu, X.-Q., Zhang, C., He, W., Wang, H., Chen, Y.-H., Liu, X.-J., Chen, X., & Xu, D.-X. (2016) · Scientific Reports · doi:10.1038/srep33513 · Cited by 18
Metadata
- Authors
- Engelking, L. J., Kuriyama, H., Hammer, R. E., Horton, J. D., Brown, M. S., Goldstein, J. L., & Liang, G.
- Venue
- Journal of Clinical Investigation
- Published
- 2004-04-15
- Volume
- 113
- Issue
- 8
- Pages
- 1168-1175
- ISSN
- 0021-9738
- Cited by
- 249
- References
- 3
- Language
- en
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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