Chemotherapy-induced senescence, an adaptive mechanism driving resistance and tumor heterogeneity

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · cited 2× · see citing works

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383 · see citing works

Tumour-associated macrophages as treatment targets in oncology

Mantovani, A., Marchesi, F., Malesci, A., Laghi, L., & Allavena, P. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.217 · Cited by 4,065 · see citing works

p21 in cancer: Intricate networks and multiple activities

Abbas, T., & Dutta, A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2657 · Cited by 2,712 · see citing works

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Bartkova, J., Hořejší, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., et al. (2005) · Nature · doi:10.1038/nature03482 · Cited by 2,688 · see citing works

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473 · see citing works

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · cited 2× · see citing works

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · cited 2× · see citing works

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160 · see citing works

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · cited 2× · see citing works

Senescence of activated stellate cells limits liver fibrosis

Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.06.049 · Cited by 2,029 · see citing works

Senescence of Activated Stellate Cells Limits Liver Fibrosis

Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993 · see citing works

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730 · see citing works

Reversal of human cellular senescence: roles of the p53 and p16 pathways

Beauséjour, C. M., Krtolica, A., Galimi, F., Narita, M., Lowe, S. W., Yaswen, P., & Campisi, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg417 · Cited by 1,457 · see citing works

Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0241 · Cited by 1,338 · see citing works

Cytoplasmic chromatin triggers inflammation in senescence and cancer

Dou, Z., Ghosh, K., Vizioli, M. G., Zhu, J., Sen, P., Wangensteen, K. J., Simithy, J., Lan, Y., Lin, Y., Zhou, Z., et al. (2017) · Nature · doi:10.1038/nature24050 · Cited by 1,335 · see citing works

Senescence-associated reprogramming promotes cancer stemness

Milanovic, M., Fan, D. N. Y., Belenki, D., Däbritz, J. H. M., Zhao, Z., Yu, Y., Dörr, J. R., Dimitrova, L., Lenze, D., Monteiro Barbosa, I. A., et al. (2018) · Nature · doi:10.1038/nature25167 · Cited by 1,131 · see citing works

CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma

Advani, R. H., Flinn, I. W., Popplewell, L. L., Forero, A., Bartlett, N. L., Ghosh, N., Kline, J. P., Roschewski, M. J., LaCasce, A. S., Collins, G. P., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1807315 · Cited by 1,125 · see citing works

A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy

Schmitt, C. A., Fridman, J. S., Yang, M., Lee, S., Baranov, E., Hoffman, R. M., & Lowe, S. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00734-1 · Cited by 1,050 · see citing works

Senescence and apoptosis: dueling or complementary cell fates?

Childs, B. G., Baker, D. J., Kirkland, J. L., Campisi, J., & van Deursen, J. M. (2014) · The EMBO Reports · doi:10.15252/embr.201439245 · Cited by 915 · see citing works

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

Sharpless, N. E., Bardeesy, N., Lee, K.-H., Carrasco, D., Castrillon, D. H., Aguirre, A. J., Wu, E. A., Horner, J. W., & DePinho, R. A. (2001) · Nature · doi:10.1038/35092592 · Cited by 848 · see citing works

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Herranz, N., Gallage, S., Mellone, M., Wuestefeld, T., Klotz, S., Hanley, C. J., Raguz, S., Acosta, J. C., Innes, A. J., Banito, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3225 · Cited by 788 · see citing works

If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

Roninson, I. B., Broude, E. V., & Chang, B.-D. (2001) · Drug Resistance Updates · doi:10.1054/drup.2001.0213 · Cited by 720 · see citing works

An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer

Weichselbaum, R. R., Ishwaran, H., Yoon, T., Nuyten, D. S. A., Baker, S. W., Khodarev, N. N., Su, A. W., Shaikh, A. Y., Roach, P., Kreike, B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809242105 · Cited by 618 · see citing works

Untitled work

(2003) · PubMed · Cited by 608 · see citing works

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

Sikic, B. I., Lakhani, N. J., Patnaik, A., Shah, S. A., Chandana, S. R., Rasco, D. W., Colevas, A. D., O’Rourke, T. J., Narayanan, S., Papadopoulos, K. P., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.18.02018 · Cited by 603 · see citing works

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

Mosteiro, L., Pantoja, C., Alcazar, N., Marión, R. M., Chondronasiou, D., Rovira, M., Fernandez-Marcos, P. J., Muñoz-Martin, M., Blanco-Aparicio, C., Pastor, J., et al. (2016) · Science · doi:10.1126/science.aaf4445 · Cited by 589 · see citing works

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

Marusyk, A., Tabassum, D. P., Altrock, P. M., Almendro, V., Michor, F., & Polyák, K. (2014) · Nature · doi:10.1038/nature13556 · Cited by 588 · see citing works

The dynamic nature of senescence in cancer

Lee, S., & Schmitt, C. A. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0249-2 · Cited by 588 · see citing works

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

Yu, J., Wang, Z., Kinzler, K. W., Vogelstein, B., & Zhang, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2627984100 · Cited by 565 · see citing works

Tumorigenesis: it takes a village

Tabassum, D. P., & Polyák, K. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3971 · Cited by 558 · see citing works

Lysosome-mediated processing of chromatin in senescence

Ivanov, A., Pawlikowski, J., Manoharan, I., van Tuyn, J., Nelson, D. M., Rai, T. S., Shah, P. P., Hewitt, G., Korolchuk, V. I., Passos, J. F., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201212110 · Cited by 539 · see citing works

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

Rodier, F., Muñoz, D. P., Teachenor, R., Chu, V., Le, O., Bhaumik, D., Coppé, J.-P., Campeau, E., Beauséjour, C. M., Kim, S.-H., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.071340 · Cited by 535 · see citing works

NOTCH1 mediates a switch between two distinct secretomes during senescence

Hoare, M., Ito, Y., Kang, T.-W., Weekes, M. P., Matheson, N. J., Patten, D. A., Shetty, S., Parry, A. J., Menon, S., Salama, R., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3397 · Cited by 522 · see citing works

Signalling strength determines proapoptotic functions of STING

Gulen, M. F., Koch, U., Haag, S. M., Schuler, F., Apetoh, L., Villunger, A., Radtke, F., & Ablasser, A. (2017) · Nature Communications · doi:10.1038/s41467-017-00573-w · Cited by 505 · see citing works

SIRPα–CD47 Immune Checkpoint Blockade in Anticancer Therapy

Veillette, A., & Chen, J. (2018) · Trends in Immunology · doi:10.1016/j.it.2017.12.005 · Cited by 476 · see citing works

Inside and out: the activities of senescence in cancer

Pérez-Mancera, P. A., Young, A. R. J., & Narita, M. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3773 · Cited by 462 · see citing works

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

Burd, C. E., Sorrentino, J. A., Clark, K. S., Darr, D. B., Krishnamurthy, J., Deal, A. M., Bardeesy, N., Castrillon, D. H., Beach, D. H., & Sharpless, N. E. (2013) · Cell · doi:10.1016/j.cell.2012.12.010 · Cited by 419 · see citing works

Molecular dissection of formation of senescence-associated heterochromatin foci

Zhang, R., Chen, W., & Adams, P. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02019-06 · Cited by 415 · see citing works

Interaction between RasV12 and scribbled clones induces tumour growth and invasion

Wu, M., Pastor-Pareja, J. C., & Xu, T. (2010) · Nature · doi:10.1038/nature08702 · Cited by 388 · see citing works

A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer

Calbó, J., van Montfort, E. H. N., Proost, N., van Drunen, E., Beverloo, H. B., Meuwissen, R. L. J., & Berns, A. J. M. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.021 · Cited by 366 · see citing works

p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer

Jackson, J. G., Pant, V., Li, Q., Chang, L. L., Quintás-Cardama, A., Garza, D., Tavana, O., Yang, P., Manshouri, T., Li, Y., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.027 · Cited by 329 · see citing works

STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells

Khodarev, N. N., Beckett, M., Labay, E., Darga, T. E., Roizman, B., & Weichselbaum, R. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308102100 · Cited by 327 · see citing works

BCR/ABL Regulates Mammalian RecA Homologs, Resulting in Drug Resistance

Słupianek, A., Schmütte, C., Tombline, G., Nieborowska-Skorska, M., Hoser, G., Nowicki, M. O., Pierce, A. J., Fishel, R. A., & Skórski, T. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00357-4 · Cited by 313 · see citing works

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

Galanos, P., Vougas, K., Walter, D., Polyzos, A., Maya-Mendoza, A., Haagensen, E. J., Kokkalis, A., Roumelioti, F.-M., Gagos, S., Tzetis, M., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3378 · Cited by 308 · see citing works

Identification of senescent cell surface targetable protein DPP4

Kim, K. M., Noh, J. H., Bodogai, M., Martindale, J. L., Yang, X., Indig, F. E., Basu, S. K., Ohnuma, K., Morimoto, C., Johnson, P. F., et al. (2017) · Genes & Development · doi:10.1101/gad.302570.117 · Cited by 270 · see citing works

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesisPreprint

Vredeveld, L. C. W., Possik, P. A., Smit, M. A., Meissl, K., Michaloglou, C., Horlings, H. M., Ajouaou, A., Kortman, P. C., Dankort, D. L., McMahon, M., et al. (2012) · Genes & Development · doi:10.1101/gad.187252.112 · Cited by 258 · see citing works

Cytosolic DNA Sensing in Organismal Tumor Control

Vanpouille-Box, C., Demaria, S., Formenti, S. C., & Galluzzi, L. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.05.013 · Cited by 250 · see citing works

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Georgilis, A., Klotz, S., Hanley, C. J., Herranz, N., Weirich, B., Morancho, B., Leote, A. C., D'Artista, L., Gallage, S., Seehawer, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.06.007 · Cited by 237 · cited 2× · see citing works

Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis

Bennecke, M., Kriegl, L., Bajbouj, M., Retzlaff, K., Robine, S., Jung, A., Arkan, M. C., Kirchner, T., & Greten, F. R. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.06.013 · Cited by 186 · see citing works

HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

Rai, T. S., Cole, J. J., Nelson, D. M., Dikovskaya, D., Faller, W. J., Vizioli, M. G., Hewitt, R. N., Anannya, O., McBryan, T., Manoharan, I., et al. (2014) · Genes & Development · doi:10.1101/gad.247528.114 · Cited by 162 · see citing works

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M. R., Qutob, N., van Rooijen, E., Werner-Klein, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.01.002 · Cited by 156 · see citing works

Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax

Leverson, J. D., Sampath, D., Souers, A. J., Rosenberg, S. H., Fairbrother, W. J., Amiot, M., Konopleva, M. Y., & Letai, A. G. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0797 · Cited by 126 · see citing works

Senescence-Associated Oxidative DNA Damage Promotes the Generation of Neoplastic Cells

Gosselin, K., Martien, S., Pourtier, A., Vercamer, C., Ostoich, P. V., Morat, L., Sabatier, L., Duprez, L., de Roodenbeke, C. T., Gilson, É., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2510 · Cited by 109 · see citing works

A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer

Kaur, S., ELKAHLOUN, A. G., SINGH, S. P., Chen, Q., Meerzaman, D. M., Song, T., Manu, N., Wu, W., Mannan, P., Garfield, S. H., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7100 · Cited by 108 · see citing works

STAT1

Thomas, M., Finnegan, C. E., Rogers, K., Purcell, J. W., Trimble, A., Johnston, P. G., & Boland, M. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1864 · Cited by 99 · see citing works

Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment

Guillon, J., Petit, C., Moreau, M., Toutain, B., Henry, C., Roché, H., Bonichon-Lamichhane, N., Salmon, J. P., Lemonnier, J., Campone, M., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1406-7 · Cited by 90 · see citing works

The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition

Courapied, S., Sellier, H., de Carné Trécesson, S., Vigneron, A., Bernard, A.-C., Gamelin, E., Barré, B., & Coqueret, O. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.092304 · Cited by 76 · see citing works

Blockade of CD47 increases survival of mice exposed to lethal total body irradiation

Soto‐Pantoja, D. R., Ridnour, L. A., Wink, D. A., & Roberts, D. D. (2013) · Scientific Reports · doi:10.1038/srep01038 · Cited by 72 · see citing works

Regulation of senescence escape by the cdk4–EZH2–AP2M1 pathway in response to chemotherapy

Duff, M. L., Gouju, J., Jonchère, B., Guillon, J., Toutain, B., Boissard, A., Henry, C., Guette, C., Lelièvre, E., & Coqueret, O. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0209-y · Cited by 65 · see citing works

The EGFR-STAT3 Oncogenic Pathway Up-regulates the Eme1 Endonuclease to Reduce DNA Damage after Topoisomerase I Inhibition

Vigneron, A. M., Gamelin, E. C., & Coqueret, O. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5115 · Cited by 64 · see citing works

Src Inhibits Adriamycin-Induced Senescence and G2 Checkpoint Arrest by Blocking the Induction of p21waf1

Vigneron, A. M., Roninson, I. B., Gamelin, E. C., & Coqueret, O. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0461 · Cited by 61 · see citing works

Escape from p21-mediated Oncogene-induced Senescence Leads to Cell Dedifferentiation and Dependence on Anti-apoptotic Bcl-xL and MCL1 Proteins

Trécesson, S. D. C., Guillemin, Y., Bélanger, A., Bernard, A.-C., Preisser, L., Ravon, E., Gamelin, E. C., Juin, P. P., Barré, B., & Coqueret, O. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.186437 · Cited by 58 · see citing works

Thrombospondin-1 mediates oncogenic Ras–induced senescence in premalignant lung tumors

Baek, K., Bhang, D., Zaslavsky, A., Wang, L.-C., Vachani, A., Kim, C. F., Albelda, S. Μ., Evan, G. I., & Ryeom, S. W. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67465 · Cited by 56 · see citing works

Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1

Jonchère, B., Vétillard, A., Toutain, B., Lam, D., Bernard, A.-C., Henry, C., Trécesson, S. D. C., Gamelin, E. C., Juin, P. P., Guette, C., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2774 · Cited by 54 · see citing works

SCAMP4 enhances the senescent cell secretomePreprint

Kim, K. M., Noh, J. H., Bodogai, M., Martindale, J. L., Pandey, P. R., Yang, X., Biragyn, A., Abdelmohsen, K., & Gorospe, M. (2018) · Genes & Development · doi:10.1101/gad.313270.118 · Cited by 53 · see citing works

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M. R., Qutob, N., van Rooijen, E., Werner-Klein, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.009 · Cited by 46 · see citing works

Signaling Regulatory Protein (SIRP)α-CD47 Blockade Joins the Ranks of Immune Checkpoint Inhibition

Veillette, A., & Tang, Z.-H. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.19.00121 · Cited by 39 · see citing works

Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion

Deruy, E., Nassour, J., Martin, N., Vercamer, C., Malaquin, N., Bertout, J., Chelli, F., Pourtier, A., Pluquet, O., & Abbadie, C. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.533 · Cited by 38 · see citing works

Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis

Vétillard, A., Jonchère, B., Moreau, M., Toutain, B., Henry, C., Fontanel, S., Bernard, A.-C., Campone, M., Guette, C., & Coqueret, O. (2015) · Oncotarget · doi:10.18632/oncotarget.6126 · Cited by 34 · see citing works

Proteomics Approaches to Define Senescence Heterogeneity and Chemotherapy Response

Petit, C., Guillon, J., Toutain, B., Boissard, A., Patsouris, A., Lelièvre, E., Guette, C., & Coqueret, O. (2019) · PROTEOMICS · doi:10.1002/pmic.201800447 · Cited by 5 · see citing works

Unveiling the mechanisms and challenges of cancer drug resistance

Khan, S. U., Fatima, K., Aisha, S., & Malik, F. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01302-1 · Cited by 417 · see citing works

Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology

Thorel, L., Perréard, M., Florent, R., Divoux, J., Coffy, S., Vincent, A., Gaggioli, C., Guasch, G., Gidrol, X., Weiswald, L., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01272-5 · Cited by 228 · see citing works

The redox-senescence axis and its therapeutic targeting

Ngoi, N. Y. L., Liew, A. Q. X., Chong, S. J. F., Davids, M. S., Clement, M., & Pervaiz, S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102032 · Cited by 90 · see citing works

Senescence-Associated Pro-inflammatory Cytokines and Tumor Cell Plasticity

Vernot, J. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00063 · Cited by 83 · see citing works

Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells

Colucci, M., Zumerle, S., Bressan, S., Gianfanti, F., Troiani, M., Valdata, A., D’Ambrosio, M., Pasquini, E., Varesi, A., Cogo, F., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.02.004 · Cited by 85 · see citing works

Strategies for senolytic drug discovery

Power, H., Valtchev, P., Dehghani, F., & Schindeler, A. (2023) · Aging Cell · doi:10.1111/acel.13948 · Cited by 81 · see citing works

Stress-Induced Polyploid Giant Cancer Cells: Unique Way of Formation and Non-Negligible Characteristics

Song, Y.-W., Zhao, Y., Deng, Z., Zhao, R.-Y., & Huang, Q. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.724781 · Cited by 57 · see citing works

Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models

Krenács, T., Meggyesházi, N., Forika, G., Kiss, E., Hamar, P., Székely, T., & Vancsik, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176270 · Cited by 61 · see citing works

Polyploid giant cancer cells: origin, possible pathways of formation, characteristics, and mechanisms of regulation

Liu, P., Wang, L., & Yu, H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1410637 · Cited by 56 · see citing works

Chemotherapy as a regulator of extracellular matrix-cell communication: Implications in therapy resistance

Gonzalez‐Molina, J., Moyano‐Galceran, L., Single, A., Gultekin, O., Alsalhi, S., & Lehti, K. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.03.012 · Cited by 53 · see citing works

MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence

Lettieri-Barbato, D., Aquilano, K., Punziano, C., Minopoli, G., & Faraonio, R. (2022) · Antioxidants · doi:10.3390/antiox11030480 · Cited by 51 · see citing works

Cellular senescence and hematological malignancies: From pathogenesis to therapeutics

Hu, D., Yuan, S., Zhong, J., Liu, Z., Wang, Y., Liu, L., Li, J., Wen, F., Liu, J., & Zhang, J. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107817 · Cited by 45 · see citing works

Curcumin and its anti‐colorectal cancer potential: From mechanisms of action to autophagy

Brockmueller, A., de Porras, V. R., & Shakibaei, M. (2024) · Phytotherapy Research · doi:10.1002/ptr.8220 · Cited by 43 · see citing works

tRNA biogenesis and specific aminoacyl-tRNA synthetases regulate senescence stability under the control of mTOR

Guillon, J., Coquelet, H., Leman, G., Toutain, B., Petit, C., Henry, C., Boissard, A., Guette, C., & Coqueret, O. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009953 · Cited by 36 · see citing works

On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm

Conod, A., Silvano, M., & Altaba, A. R. I. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110490 · Cited by 34 · see citing works

Promising new drugs and therapeutic approaches for treatment of ovarian cancer—targeting the hallmarks of cancer

Hillmann, J. S., Maass, N., Bauerschlag, D., & Flörkemeier, I. (2025) · BMC Medicine · doi:10.1186/s12916-024-03826-w · Cited by 35 · see citing works

Identification of a novel gene signature predicting response to first-line chemotherapy in BRCA wild-type high-grade serous ovarian cancer patients

Buttarelli, M., Ciucci, A., Palluzzi, F., Raspaglio, G., Marchetti, C., Perrone, E., Minucci, A., Giacò, L., Fagotti, A., Scambia, G., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02265-w · Cited by 32 · see citing works

Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy

Jaber, S., Warnier, M., Leers, C., Vernier, M., Goehrig, D., Médard, J., Vindrieux, D., Ziegler, D. V., & Bernard, D. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00116-4 · Cited by 29 · see citing works

Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer

Kujundžić, R. N., Prpić, M., Đaković, N., Dabelić, N., Tomljanović, M., Mojzeš, A., Fröbe, A., & Gall‐Tros̆elj, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115681 · Cited by 28 · see citing works

Cisplatin Induces Senescent Lung Cancer Cell-Mediated Stemness Induction via GRP78/Akt-Dependent Mechanism

Sriratanasak, N., Chunhacha, P., Zin, Z., & Pithi Chanvorachote, B. (2022) · Biomedicines · doi:10.3390/biomedicines10112703 · Cited by 28 · see citing works

The post-chemotherapy changes of tumor physical microenvironment: Targeting extracellular matrix to address chemoresistance

Li, Y., Jin, G., Liu, N., Guo, H., & Xu, F. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216583 · Cited by 28 · see citing works

State-of-the-Art Liver Cancer Organoids: Modeling Cancer Stem Cell Heterogeneity for Personalized Treatment

Giron‐Michel, J., Padelli, M., Oberlin, E., Guénou, H., & Duclos‐Vallée, J. (2025) · BioDrugs · doi:10.1007/s40259-024-00702-0 · Cited by 30 · see citing works

Cancer extracellular vesicles as novel regulators of NK cell response

Soriani, A., Vulpis, E., Cuollo, L., Santoni, A., & Zingoni, A. (2019) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.11.007 · Cited by 21 · see citing works

STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells

Mikyšková, R., Sapeg, O., Psotka, M., Novotny, O., Hodný, Z., Balintova, S., Maliňák, D., Svobodová, J., Andrýs, R., Rysanek, D., et al. (2023) · Molecular Medicine Reports · doi:10.3892/mmr.2023.12968 · Cited by 19 · see citing works

Zinc Oxide Nanoparticles Can Intervene in Radiation-Induced Senescence and Eradicate Residual Tumor Cells

Wiesmann, N., Gieringer, R., Viel, M., Eckrich, J., Tremel, W., & Brieger, J. (2021) · Cancers · doi:10.3390/cancers13122989 · Cited by 19 · see citing works

Selenylated Imidazo[1,2-a]pyridine Induces Cell Senescence and Oxidative Stress in Chronic Myeloid Leukemia Cells

Burkner, G. T., Dias, D. A., de Souza, K. F. S., de Araújo, A. J. P., Basilio, D. C. L. S., Jacobsen, F. T., de Moraes, A. C. R., Silva-Filho, S. E., Cavalcante, M. F. D. O., Moraes, C. A. O., et al. (2023) · Molecules · doi:10.3390/molecules28020893 · Cited by 19 · see citing works

Therapeutic Implications of the Drug Resistance Conferred by Extracellular Vesicles Derived from Triple-Negative Breast Cancer Cells

Yi, Y. W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043704 · Cited by 19 · see citing works

Modeling of senescence-related chemoresistance in ovarian cancer using data analysis and patient-derived organoids

Cai, X., Li, Y., Zheng, J., Liu, L., Jiao, Z., Lin, J., Jiang, S., Lin, X., & Sun, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2023.1291559 · Cited by 19 · see citing works

Apoptosis in the Pancreatic Cancer Tumor Microenvironment—The Double-Edged Sword of Cancer-Associated Fibroblasts

Pfeifer, E., Burchell, J., Dazzi, F., Sarker, D., & Beatson, R. (2021) · Cells · doi:10.3390/cells10071653 · Cited by 20 · see citing works

Inhibition of glutaminase elicits senolysis in therapy-induced senescent melanoma cells

Kim, J., Brunetti, B., Kumar, A., Mangla, A., Honda, K. S., & Yoshida, A. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07284-3 · Cited by 17 · see citing works

MicroRNA‑7 modulates cellular senescence to relieve gemcitabine resistance by targeting PARP1/NF‑κB signaling in pancreatic cancer cells

Ye, Z., Che, H.-B., Zhang, T.-Y., Chen, Z., Tian, L., & Gu, D.-N. (2020) · Oncology Letters · doi:10.3892/ol.2020.12400 · Cited by 16 · see citing works

A Dual-Payload Bispecific ADC Improved Potency and Efficacy over Single-Payload Bispecific ADCs

Wilski, N. A., Haytko, P., Zha, Z., Wu, S., Jin, Y., Chen, P., Han, C., & Chiu, M. L. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17080967 · Cited by 15 · see citing works

Detection of Cellular Senescence in Human Primary Melanocytes and Malignant Melanoma Cells In Vitro

Zimmermann, T., Pommer, M., Kluge, V., Chiheb, C., Muehlich, S., & Bosserhoff, A. (2022) · Cells · doi:10.3390/cells11091489 · Cited by 15 · see citing works

The Role of Aging and Senescence in Immune Checkpoint Inhibitor Response and Toxicity

Jain, S. S., Sojo, G. B., Sun, H., Friedland, B. N., McNamara, M. E., Schmidt, M. O., & Wellstein, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137013 · Cited by 16 · see citing works

Removal of gemcitabine‐induced senescent cancer cells by targeting glutaminase1 improves the therapeutic effect in pancreatic ductal adenocarcinoma

Oyama, K., Iwagami, Y., Kobayashi, S., Sasaki, K., Yamada, D., Tomimaru, Y., Noda, T., Asaoka, T., Takahashi, H., Tanemura, M., et al. (2023) · International Journal of Cancer · doi:10.1002/ijc.34725 · Cited by 14 · see citing works

Blockade of integrin signaling reduces chemotherapy-induced premature senescence in collagen cultured bladder cancer cells

Deng, L., Jin, K., Zhou, X., Zhang, Z., Ge, L., Xiong, X., Su, X., Jin, D., Yuan, Q., Zhang, C., et al. (2022) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbac007 · Cited by 13 · see citing works

Cellular uptake and retention studies of silica nanoparticles utilizing senescent fibroblasts

Perrigue, P. M., Henschke, A., Grześkowiak, B. F., Przysiecka, Ł., Jaskot, K., Mielcarek, A., Coy, E. L., & Moya, S. E. (2023) · Scientific Reports · doi:10.1038/s41598-022-26979-1 · Cited by 14 · see citing works

The role of host response to chemotherapy: resistance, metastasis and clinical implications

Deo, A., Sleeman, J. P., & Shaked, Y. (2023) · Clinical & Experimental Metastasis · doi:10.1007/s10585-023-10243-5 · Cited by 14 · see citing works

The senescent mesothelial matrix accentuates colonization by ovarian cancer cells

Thapa, B. V., Banerjee, M., Glimm, T., Saini, D. K., & Bhat, R. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05017-x · Cited by 12 · see citing works

Autophagy and senescence facilitate the development of antiestrogen resistance in ER positive breast cancer

McGrath, M. K., Abolhassani, A., Guy, L., Elshazly, A. M., Barrett, J. T., Mivechi, N. F., Gewirtz, D. A., & Schoenlein, P. V. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1298423 · Cited by 13 · see citing works

SEZ6L2 Is an Important Regulator of Drug-Resistant Cells and Tumor Spheroid Cells in Lung Adenocarcinoma

Lee, J.-S., Kim, H. Y., Won, B., Kang, S. W., Kim, Y.-N., & Jang, H. (2020) · Biomedicines · doi:10.3390/biomedicines8110500 · Cited by 12 · see citing works

TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanisms

Calistri, N. L., Liby, T. A., Hu, Z., Zhang, H., Dane, M. A., Gross, S. M., & Heiser, L. M. (2025) · Scientific Reports · doi:10.1038/s41598-024-82218-9 · Cited by 9 · see citing works

Navigating the paradox of senescence and chemoresistance in pancreatic cancer

Jeiroshi, A., Deng, J., Xu, Z., Comandatore, A., Xu, G., Glaviano, A., Morelli, L., Garajová, I., & Giovannetti, E. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.06.007 · Cited by 10 · see citing works

Glutaminase-1 inhibition alleviates senescence of Wharton’s jelly-derived mesenchymal stem cells via senolysis

Lee, E. J., Kim, S. J., Jeon, S. Y., Chung, S., Park, S. E., Kim, J., Choi, S., Oh, S., Ryu, G. H., Jeon, H. B., et al. (2024) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szae053 · Cited by 8 · see citing works

Epigenomic reprogramming of therapy-resistant circulating tumor cells in colon cancer

Bao‐Caamano, A., Costa‐Fraga, N., Cayrefourcq, L., Rodríguez‐Casanova, A., Muinelo‐Romay, L., López‐López, R., Alix‐Panabières, C., & Díaz‐Lagares, Á. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1291179 · Cited by 8 · see citing works

Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10

Alhallak, I., Wolter, K. G., Munoz, A. C., Simmen, F. A., Ward, R. J., Petty, S. A., Li, L., & Simmen, R. C. M. (2021) · Journal of Molecular Endocrinology · doi:10.1530/jme-21-0100 · Cited by 8 · see citing works

Melatonin Protects K15+ Human Hair Follicle Stem Cells and Hair Matrix Keratinocytes against Paclitaxel-Induced Damage Ex Vivo

Samra, T., Chéret, J., Gherardini, J., Verling, S. D., Kassir, R., & Paus, R. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.09.004 · Cited by 7 · see citing works

Pyridazinone Derivatives Limit Osteosarcoma-Cells Growth In Vitro and In Vivo

Moniot, A., Braux, J., Bour, C., Guillaume, C., Lamret, F., Allart‐Simon, I., Audonnet, S., Renault, S., Rédiní, F., Laronze‐Cochard, M., et al. (2021) · Cancers · doi:10.3390/cancers13235992 · Cited by 7 · see citing works

DNMT3A governs tyrosine kinase inhibitors responses through IAPs and in a cell senescence-dependent manner in non-small cell lung cancer.

Deng, Q., Li, C., Liu, J., Ji, X., Wan, X., Wang, C., Sun, H., Fang, Q., Gu, W.-Q., Ma, C., et al. (2023) · PubMed Central · Cited by 7 · see citing works

The botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, sensitizes alveolar and embryonal rhabdomyosarcoma to radiotherapy in vitro and in vivo

Vaccaro, S., Rossetti, A., Porrazzo, A., Camero, S., Cassandri, M., Pomella, S., Tomaciello, M., Macioce, G., Pedini, F., Barillari, G., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1071176 · Cited by 6 · see citing works

ITGA1, the alpha 1 subunit of integrin receptor, is a novel marker of drug-resistant senescent melanoma cells in vitro

Słaby, J., Wnuk, M., Błoniarz, D., Stec, P., Szmatoła, T., Kaznowska, E. B., Reich, A., Moros, M., & Lewińska, A. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04028-w · Cited by 6 · see citing works

Increased Expression of the RBPMS Splice Variants Inhibits Cell Proliferation in Ovarian Cancer Cells

Rabelo-Fernández, R. J., Rivera, R. A. N., Santana‐Rivera, Y., Tous-Beveraggi, J., Valiyeva, F., & Vivas‐Mejía, P. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314742 · Cited by 6 · see citing works

Primary Sclerosing Cholangitis–Associated Cholangiocarcinoma Demonstrates High Intertumor and Intratumor Heterogeneity

Kamp, E. J. C. A., Peppelenbosch, M. P., Doukas, M., Verheij, J., Ponsioen, C. Y., van Marion, R., Bruno, M. J., Koerkamp, B. G., Dinjens, W. N. M., & de Vries, A. C. (2021) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000410 · Cited by 6 · see citing works

Advanced glycation end product (AGE) targeting antibody SIWA318H is efficacious in preclinical models for pancreatic cancer

Rossi, G. R., Jensen, A., Ng, S., Yin, Z., Li, A., Misra, A., Hoff, D. D. V., Gruber, L., Gruber, M., & Han, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-44211-6 · Cited by 5 · see citing works

The Importance of Marital Status in the Morbidity and Prognosis of Lung Metastasis in Newly Diagnosed Ovarian Cancer

Qian, L., Chen, Y., Peng, M., Xia, Y., Zhou, T., Hong, J., & Ding, S. (2023) · Journal of Cancer · doi:10.7150/jca.83017 · Cited by 5 · see citing works

The impact of Charcot-Leyden Crystal protein on mesothelioma chemotherapy: targeting eosinophils for enhanced chemosensitivity

Willems, M., Hamaïdia, M., Fontaine, A., Grégoire, M., Halkin, L., Mañá, L. V., Terres, R., Jamakhani, M., Deshayes, S., Brostaux, Y., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105418 · Cited by 5 · see citing works

A non‐canonical role for the tyrosyl tRNA synthetase: YARS regulates senescence induction and escape and controls the transcription of LIN9

Coquelet, H., Leman, G., Maarouf, A., Petit, C., Toutain, B., Henry, C., Boissard, A., Guette, C., Lelièvre, E., Vidi, P., et al. (2025) · FEBS Journal · doi:10.1111/febs.17381 · Cited by 4 · see citing works

Identification the Cellular Senescence Associated lncRNA LINC01579 in Gastric Cancer

He, J., Fu, Z., Zou, B., Lei, X., Lei, L., Yang, Q., & Li, G. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70360 · Cited by 4 · see citing works

Tumor heterogeneity: how could we use it to achieve better clinical outcomes?

Yousef, A. G., Ghobrial, L., & Diamandis, E. P. (2023) · Diagnosis · doi:10.1515/dx-2023-0108 · Cited by 4 · see citing works

The Amelioration of Side Effects Associated with Chemotherapy

Agrawal, P., & Jain, M. (2024) · Current Cancer Therapy Reviews · doi:10.2174/0115733947274568231121173724 · Cited by 4 · see citing works

PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation

Palanivel, C., Madduri, L. S. V., Hein, A. L., Jenkins, C. B., Graff, B. T., Camero, A. L., Zhou, S., Enke, C. A., Ouellette, M. M., & Yan, Y. (2024) · Aging · doi:10.18632/aging.205619 · Cited by 4 · see citing works

Defining melanoma combination therapies that provide senolytic sensitivity in human melanoma cells

Tchelougou, D., Malaquin, N., Cardin, G. B., Desmul, J., Turcotte, S., & Rodier, F. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1368711 · Cited by 4 · see citing works

Serum IL‐6 and MCP‐1 concentrations in dogs with lymphoma before and after doxorubicin treatment as a potential marker of cellular senescence

Evans, B. L., Fenger, J. M., Ballash, G., & Brown, M. E. (2021) · Veterinary Medicine and Science · doi:10.1002/vms3.633 · Cited by 4 · see citing works

Nucleobindin 2 inhibits senescence in gastric carcinoma

Ishibashi, Y., Itoh, T., Oguri, Y., Hashimura, M., Yokoi, A., Matsumoto, T., Harada, Y., Fukagawa, N., Hayashi, M., Ono, M., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-61111-5 · Cited by 4 · see citing works

Mapping the Progression of Therapy-Induced Senescence to Therapy Tolerance: An Evolutionarily Conserved Mechanism for Optimizing Cancer Treatment with Senotherapeutics

Mukherjee, G., Dutta, N., Ramanathan, M., Bhattacharyya, K., Das, A., Haider, S., Chowdhury, G., & Chakrabarty, A. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00374 · Cited by 3 · see citing works

Crosstalk between TGF-β and Wnt/β-catenin signaling drives fibrogenic and stem-like phenotypes in senescent MDA-MB-231 breast cancer cells

Samarji, M. E., Alam, E., Dakramanji, M., Bassam, M., Santina, J., Ayoub, M., Aprahamian, A., & Rima, M. (2026) · npj Aging · doi:10.1038/s41514-025-00322-0 · Cited by 3 · see citing works

Les tumoroïdes, modèles precliniques en plein essor pour l’oncologie

Thorel, L., Florent, R., Perréard, M., Vincent, A., Poulain, L., & Weiswald, L. (2022) · médecine/sciences · doi:10.1051/medsci/2022148 · Cited by 3 · see citing works

Unlocking the Potential of Therapy-Induced Cytokine Responses: Illuminating New Pathways in Cancer Precision Medicine

Gunturu, D. R., Hassan, M. I., Bedi, D., Datta, P. K., Manne, U., & Samuel, T. (2024) · Current Oncology · doi:10.3390/curroncol31030089 · Cited by 3 · see citing works

Discovery of drug transporter inhibitors tied to long noncoding RNA in resistant cancer cells; a computational model -in silico- study

Diab, M., Hamdi, A., Al-Obeidat, F. N., Hafez, W., Cherrez-Ojeda, I., Gador, M., Rashid, G., Elkhazin, S. F., Ibrahim, M. A., Ismail, T., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1511029 · Cited by 2 · see citing works

The challenge of disappearing colorectal liver metastasis: balancing considerations between tumor biology and clinical consequence for liver surgery

Ansari, D., Rystedt, J. L., Søreide, K., Lindberg, M., & Andersson, R. (2025) · Clinical & Experimental Metastasis · doi:10.1007/s10585-025-10357-y · Cited by 2 · see citing works

Targeting hexokinase 2 to induce breast cancer cell senescence

Bischof, H., Cisarova, K. V., Burgstaller, S., Schwerer, M., Absenger‐Novak, M., Jost, P. J., Malli, R., Graier, W. F., & Łukowski, R. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70282 · Cited by 2 · see citing works

Chemotherapy-induced chemobrain and cognitive decline: A pharmacological perspective on neurovascular injury as a therapeutic target

Nagy, D., Chandragiri, S. S., Kordestan, K. V., Ekambaram, S., Nagykaldi, M., Patai, R., Gulej, R., Nagaraja, R. Y., Brunner, E., Kristóf, R., et al. (2026) · Advances in Translational Research · doi:10.1556/1661.2026.00111 · Cited by 3 · see citing works

MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER+ Breast Cancer

Wörthmüller, J., Disler, S., Pradervand, S., Richard, F., Haerri, L., Buendía, G. A. R., Fournier, N., Desmedt, C., & Rüegg, C. (2023) · Cells · doi:10.3390/cells12151929 · Cited by 2 · see citing works

Modulation of tumor plasticity by senescent cells: Deciphering basic mechanisms and survival pathways to unravel therapeutic options

Silva, A. O., Bitencourt, T. C., Vargas, J. E., Fraga, L. R., & Filippi‐Chiela, E. C. (2024) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2023-0311 · Cited by 2 · see citing works

Impacts of Senolytic Phytochemicals on Gut Microbiota: A Comprehensive Review

Kim, H. S., & Jung, C. H. (2024) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2408.08032 · Cited by 1 · see citing works

Exploring the uncharted role of cell senescence in rare diseases

Selvaggio, P., Taci, E., Barassi, A., Massa, V., Gervasini, C., Lesma, E. A., Bernardelli, C., & Fede, E. D. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-025-03778-1 · Cited by 1 · see citing works

HSP90 inhibition potentiates oxidant-based antimelanoma action of novel thioquercetin derivatives by compromising AhR/CYP1A1 pathway

Witkowski, W., Słaby, J., Wnuk, M., Stec, P., Piotrowski, P., Żebrowski, M., Cybularczyk‐Cecotka, M., Deręgowska, A., Romanchikova, N., Zayakin, P., et al. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02311-4 · Cited by 1 · see citing works

Cellular senescence and aging at the crossroad between immunity and cancer

Kepp, O., Galluzzi, L., & Petroni, G. (2024) · Methods in cell biology · doi:10.1016/s0091-679x(24)00009-8 · Cited by 1 · see citing works

Establishment of a chemoresistant laryngeal cancer cell model to study chemoresistance and chemosensitization responses via transcriptomic analysis and a tumor‐on‐a‐chip platform

Moya‐Garcia, C. R., Munipalle, M., Pacis, A., Sadeghi, N., Tabrizian, M., & Li‐Jessen, N. Y. K. (2025) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10741 · Cited by 2 · see citing works

Personalised Medicine in Cervical Cancer: Evaluating Therapy Resistance Through Multi‐Model Approaches

Meyer, M., Eksteen, C., de Sousa, C., Chellan, N., van Aarde, R., Bhaga, M., Riedemann, J., Botha, M. H., der Merwe, F. H. V., & Engelbrecht, A. (2025) · Cancer Medicine · doi:10.1002/cam4.70995 · Cited by 1 · see citing works

Synthesis of thioridazine-VLA-4 antagonist hybrids usingN-propargyl northioridazine enantiomers

Martyn, A. P., Willis, A. C., & Kelso, M. J. (2020) · Synthetic Communications · doi:10.1080/00397911.2020.1785503 · Cited by 1 · see citing works

An integrated RNA-proteomic landscape of drug induced senescence in a cancer cell linePreprint

Stevenson, T., Al-Roshdi, M., Görtler, F., & Grellscheid, S. N. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.21.533605 · Cited by 1 · see citing works

Effect of Blood-Derived Products on Senescence Associated Se-Cretory Phenotype in an Etoposide Induced Senescence Human Dermal Fibroblast ModelPreprint

Kuehnel, H., Pasztorek, M., Kuten-Pella, O., Kramer, K., Bauer, C., Lacza, Z., & Nehrer, S. (2023) · Preprints.org · doi:10.20944/preprints202312.0304.v1 · Cited by 1 · see citing works

Molecular Characterization, Via Next-Generation Sequencing, of Refractory or Resistant Invasive Breast Carcinoma

Lapausa, P. P., Soria-Comes, T., Calabria, I., & Maestu, I. (2021) · Cureus · doi:10.7759/cureus.19528

Elimination of Senescent Cells by Polyphenols and Flavonoids

Harald, A. K. (2021) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_1-1

Elimination of Senescent Cells by Polyphenols and Flavonoids

Harald, A. K. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-5422-0_1

An integrated RNA-proteomic landscape of drug induced senescence in a cancer cell line

Al-Roshdi, M., Stevenson, T., Görtler, F., & Grellscheid, S. N. (2023) · F1000Research · doi:10.12688/f1000research.133203.1

TRAIL pathway suppression of cancer cell growth and immune cell-mediated tumor cell-killing in a senescent fibroblast-constructed tumor microenvironmentPreprint

Zhang, S., Huntington, K. E., Zhou, L., Seyhan, A. A., Kun, B., Carneiro, B. A., Kreiling, J. A., Sedivy, J. M., & El‐Deiry, W. S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.30.569479

The YARS Tyrosyl tRNA Synthetase Regulates Senescence Induction and Escape Through the Transcriptional Control of LIN9, a Member of the DREAM ComplexPreprint

Coquelet, H., Leman, G., Maarouf, A., Petit, C., Toutain, B., Henry, C., Boissard, A., Guette, C., Lelièvre, E., Vidi, P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.19.571263

Oncogene-induced senescence and senescence-associated secretory phenotype (SASP) determine the efficacy of palbociclib in PIK3CA mutated colorectal cancerPreprint

Cao, P., Zhou, X., Yang, S., Shen, T., Wang, S., Yu, H., Liu, X., Gong, Y., Wang, W., Wang, H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.15.623304

Tamoxifen and regulation of stress-induced senescence in breast cancer cells

Mikhaevich, E. I., Andreeva, O. E., Sorokin, D. V., Scherbakov, A. M., Kopnin, P., Gudkova, M. V., & Ma, K. (2025) · Advances in molecular oncology · doi:10.17650/2313-805x-2025-12-3-46-56

Alterations in mitochondrial and lysosomal compartments under chemotherapy-induced senescence

Shatalova, R. O., & Sheverev, D. (2025) · Bulletin of Russian State Medical University · doi:10.24075/brsmu.2025.045

Metabolic profiling of therapy-induced senescent cancer cells via TPEF, MALDI-MS, and RNA-sequencing

Ghislanzoni, S., Padelli, F., Niero, M., Bertolotti, A., Belfiore, A., Torelli, S., Bresci, A., Masella, A., Betti, S., Polli, D., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-32573-y

Validation in silico de la valeur prédictive du gène codant la protéine DDB2 (Damaged-DNA Binding 2) et caractérisation in vitro des effets de complexes organométalliques dans des modèles de cancers du sein

Cornu, F. (2020) · theses.fr (ABES) · doi:10.70675/baf8b2dcz8797z462ezb8f6zc22cdeaef32f

Rôles de très longs ARNs non codants intergéniques dans la réorganisation 3D du génome au cours de la sénescence

Ouvrard, J. (2023) · theses.fr (ABES) · doi:10.70675/f1618134z102ez441cz9ff8zade45dc23aa9

Thérapies du cancer de nouvelle génération et fonctions cognitives : Nouveaux concepts, nouveaux mécanismes, biomarqueurs originaux.

Coppola, N. (2023) · theses.fr (ABES) · doi:10.70675/0eaeed03z4d50z4014z947czedd9a2ec2c91

Thymoquinone and pentoxifylline modulate 5-fluorouracil-induced senescence and apoptosis in colorectal cancer spheroids

Makalani, F., Ghanbari, A., Tabandeh, M. R., Nasta, T. Z., Souq, A. J., & Jalili, C. (2026) · Research in Pharmaceutical Sciences · doi:10.4103/rps.rps_175_25

Cancer's nano-messengers: The mechanistic universe and therapeutic rewriting of tumor-derived exosomes

Anil, A. V., & Rajendran, K. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108440

Spontaneous cellular senescence and stress response heterogeneity in human vestibular schwannomas

Franco-Caspueñas, S., Ruiz-García, C., Contreras, J., Iturrate, A., la Rosa, L. R., Lassaletta, L., Varela‐Nieto, I., & Jimenez-Lara, A. M. (2026) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdag190

The thiocarbonyl analog of chrysin induces apoptosis and oxidative stress-mediated unfolded protein response in breast cancer cells

Witkowski, W., Deręgowska, A., Kapavarapu, R., Stec, P., Pieszko, W., Kołodziej, O., Żebrowski, M., Boruc, M., Łętowski, P., Łukaszyk, M., et al. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119201

Backup Plan: Senescence fights tumors when apoptosis fails (Cancer; Senescence)

Aschwanden, C. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.19.nw60 · Cited by 4 · see citing works

Therapy-Induced Senescence in Cancer Treatment Resistance: Mechanisms, Evidence, and Translational Opportunities

Blanco, J. R., & Carnero, A. (2026) · Cancers · doi:10.3390/cancers18193084

Cellular senescence and cancer chemotherapy resistance

Gordon, R. R., & Nelson, P. S. (2012) · Drug Resistance Updates · doi:10.1016/j.drup.2012.01.002 · Cited by 134 · see citing works

Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

Saleh, T., Bloukh, S., Carpenter, V. J., Alwohoush, E., Bakeer, J., Darwish, S., Azab, B., & Gewirtz, D. A. (2020) · Cancers · doi:10.3390/cancers12040822 · Cited by 289 · see citing works

Abstract P17: Escape From Therapy-Induced Senescence Drives ABCB1-Mediated Drug Resistance And Evades Aneuploidy Surveillance

Robert, M., Jakhar, R., Gonzalez-Trueba, L., & Crasta, K. (2026) · Cancer Research · doi:10.1158/1538-7445.fcs2025-p17