The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
Open accessAbstract
ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined by differential expression of ASCL1 , NEUROD1 , and POU2F3 (SCLC-A, -N, and -P, respectively), which are associated with distinct therapeutic vulnerabilities. To define the heterogeneity of tumors and their associated microenvironments across subtypes, we sequenced 54,523 cellular transcriptomes from 21 human biospecimens. Our single-cell SCLC atlas reveals tumor diversity exceeding lung adenocarcinoma, driven by canonical, intermediate, and admixed subtypes. We discovered a PLCG2 -high tumor cell population with stem-like, pro-metastatic features that recurs across subtypes and predicts worse overall survival, and manipulation of PLCG2 expression in cells confirms correlation with key metastatic markers. Treatment and subtype are associated with substantial phenotypic changes in the SCLC immune microenvironment, with greater T-cell dysfunction in SCLC-N than SCLC-A. Moreover, the recurrent, PLCG2- high subclone is associated with exhausted CD8+ T-cells and a pro-fibrotic, immunosuppressive monocyte/macrophage population, suggesting possible tumor-immune coordination to promote metastasis.
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Metadata
- Authors
- Chan, J. M., Quintanal-Villalonga, Á., Gao, V. R., Xie, Y., Allaj, V., Chaudhary, O., Masilionis, I., Egger, J., Chow, A., Walle, T., Mattar, M., Yarlagadda, D. V. K., Wang, J. L., Uddin, F., Offin, M., Ciampricotti, M., Qeriqi, B., Bahr, A., de Stanchina, E., Bhanot, U. K., Lai, W. V., Bott, M. J., Jones, D. R., Ruiz, A., Baine, M. K., Li, Y., Rekhtman, N., Poirier, J. T., Nawy, T., Sen, T., Mazutis, L., Hollmann, T. J., Pe'er, D., & Rudin, C. M.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 39
- Issue
- 11
- Pages
- 1479-1496.e18
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W3206940911
- Cited by
- 434
- References
- 155
- FWCI
- 21.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Chan, J. M., Quintanal-Villalonga, Á., Gao, V. R., Xie, Y., Allaj, V., Chaudhary, O., Masilionis, I., Egger, J., Chow, A., Walle, T., Mattar, M., Yarlagadda, D. V. K., Wang, J. L., Uddin, F., Offin, M., Ciampricotti, M., Qeriqi, B., Bahr, A., de Stanchina, E., . . . Rudin, C. M. (2021). Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer. Cancer Cell. https://doi.org/10.1016/j.ccell.2021.09.008
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
