Cited by 413Cell Adhesion Molecules ResearchCancer Cells and MetastasisCellular Mechanics and Interactions

Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction

Open access
White, Donald E., Kurpios, Natasza A., Zuo, Dongmei, Hassell, John A., Blaess, Sandra, Mueller, Ulrich, Muller, William J.·2004·Cancer Cell

Abstract

Despite evidence demonstrating the role of beta1-integrin in the regulation of cancer cell proliferation in vitro, the importance of this cell adhesion receptor during the initiation and progression of epithelial tumors in vivo remains unclear. Here we have used the Cre/LoxP1 recombination system to disrupt beta1-integrin function in the mammary epithelium of a transgenic mouse model of human breast cancer. Using this approach, we show that beta1-integrin expression is critical for the initiation of mammary tumorigenesis in vivo, and for maintaining the proliferative capacity of late-stage tumor cells. These observations provide a direct demonstration that beta1-integrin plays a critical role in both the initiation and maintenance of mammary tumor growth in vivo.

Integrity signals

Registry

Crossref · 10.1016/j.ccr.2004.06.025

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • ITGB1 and CD151 are pro-tumorigenic by enhancing cell migration and stromal invasion.

    “ITGB1 and CD151 are known to be pro-tumorigenic by enhancing cell migration and stromal invasion (Reuter et al., 2009, White et al., 2004, Yang et al., 2008, Zijlstra et al., 2008).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
White, D. E., Kurpios, N. A., Zuo, D., Hassell, J. A., Blaess, S., Mueller, U., & Muller, W. J.
Affiliations
  • Royal Victoria Hospital (CA)
  • McMaster University (CA)
  • Howard Hughes Medical Institute (US)
  • Scripps Research Institute (US)
Corresponding author
Muller, William J.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2004-08
Volume
6
Issue
2
Pages
159-170
ISSN
1535-6108 (ISSN-L)
OpenAlex
W2156581417
Cited by
413
References
52
Citations by year
2026: 8 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 13 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 10 · 2017: 9 · 2016: 14 · 2015: 16 · 2014: 23 · 2013: 34 · 2012: 32
FWCI
11.32
Type
journal article
Language
en
Open access
Locations
  • Cancer Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
beta1 integrin, mammary tumor progression, cell adhesion receptors, tumor cell proliferation, transgenic mouse model, Cre-loxP recombination, epithelial tumors, breast cancer
MeSH terms
Animals, Breast Neoplasms, Cell Division, Cell Transformation, Neoplastic, Female, Humans, Mammary Glands, Animal, Mice, Transgenic, Neoplasm Transplantation, Protein-Tyrosine Kinases, Tumor Cells, Cultured, Gene Targeting, Integrin beta1, Mice, Focal Adhesion Protein-Tyrosine Kinases, Focal Adhesion Kinase 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review