Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
Open accessAbstract
Despite evidence demonstrating the role of beta1-integrin in the regulation of cancer cell proliferation in vitro, the importance of this cell adhesion receptor during the initiation and progression of epithelial tumors in vivo remains unclear. Here we have used the Cre/LoxP1 recombination system to disrupt beta1-integrin function in the mammary epithelium of a transgenic mouse model of human breast cancer. Using this approach, we show that beta1-integrin expression is critical for the initiation of mammary tumorigenesis in vivo, and for maintaining the proliferative capacity of late-stage tumor cells. These observations provide a direct demonstration that beta1-integrin plays a critical role in both the initiation and maintenance of mammary tumor growth in vivo.
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ITGB1 and CD151 are pro-tumorigenic by enhancing cell migration and stromal invasion.
“ITGB1 and CD151 are known to be pro-tumorigenic by enhancing cell migration and stromal invasion (Reuter et al., 2009, White et al., 2004, Yang et al., 2008, Zijlstra et al., 2008).”
From Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020) · cites this paper as White et al., 2004
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- Authors
- White, D. E., Kurpios, N. A., Zuo, D., Hassell, J. A., Blaess, S., Mueller, U., & Muller, W. J.
- Affiliations
- Royal Victoria Hospital (CA)
- McMaster University (CA)
- Howard Hughes Medical Institute (US)
- Scripps Research Institute (US)
- Corresponding author
- Muller, William J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 6
- Issue
- 2
- Pages
- 159-170
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2156581417
- Cited by
- 413
- References
- 52
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 13 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 10 · 2017: 9 · 2016: 14 · 2015: 16 · 2014: 23 · 2013: 34 · 2012: 32
- FWCI
- 11.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- beta1 integrin, mammary tumor progression, cell adhesion receptors, tumor cell proliferation, transgenic mouse model, Cre-loxP recombination, epithelial tumors, breast cancer
- MeSH terms
- Animals, Breast Neoplasms, Cell Division, Cell Transformation, Neoplastic, Female, Humans, Mammary Glands, Animal, Mice, Transgenic, Neoplasm Transplantation, Protein-Tyrosine Kinases, Tumor Cells, Cultured, Gene Targeting, Integrin beta1, Mice, Focal Adhesion Protein-Tyrosine Kinases, Focal Adhesion Kinase 1
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