The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals
Open accessAbstract
Metastasis may arise years after removal of a primary tumor. The mechanisms allowing latent disseminated cancer cells to survive are unknown. We report that a gene-expression signature of c-Src activation is associated with late-onset bone metastasis in breast cancer. This link is independent of hormone receptor status or breast cancer subtype. In breast cancer cells, c-Src is dispensable for homing to the bones or lungs critical for the survival and outgrowth of these cells in the bone marrow. c-Src mediates AKT regulation and cancer cell survival responses to CXCL12 and TRAIL, factors which are distinctively expressed in the bone metastasis microenvironment. Breast cancer cells that lodge in the bone marrow succumb in this environment when deprived of c-Src activity.
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Self-citationGene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
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Self-citation
Cited by
Tumor Metastasis: Molecular Insights and Evolving Paradigms
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Emerging Biological Principles of Metastasis
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Metastatic colonization by circulating tumour cells
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Cancer to bone: a fatal attraction
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Metadata
- Authors
- Zhang, X. H.-F., Wang, Q., Gerald, W., Hudis, C. A., Norton, L., Smid, M., Foekens, J. A., & Massagué, J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 16
- Issue
- 1
- Pages
- 67-78
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2023720844
- Cited by
- 663
- References
- 54
- FWCI
- 25.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, X. H.-F., Wang, Q., Gerald, W., Hudis, C. A., Norton, L., Smid, M., Foekens, J. A., & Massagué, J. (2009). Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals. Cancer Cell. https://doi.org/10.1016/j.ccr.2009.05.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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