The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Basal Cell Carcinomas Arise from Hair Follicle Stem Cells in Ptch1+/− Mice
Open accessAbstract
SUMMARY Basal cell carcinomas (BCCs) are hedgehog-driven tumors that resemble follicular and interfollicular epidermal basal keratinocytes and hence long have been thought to arise from these cells. However, the actual cell of origin is unknown. Using cell fate tracking of X-ray induced BCCs in Ptch1+/− mice, we found their essentially exclusive origin to be keratin 15-expressing stem cells of the follicular bulge. However, conditional loss of p53 not only enhanced BCC carcinogenesis from the bulge but also produced BCCs from the interfollicular epidermis, at least in part by enhancing Smo expression. This latter finding is consistent with the lack of visible tumors on ears and tail, sites lacking Smo expression, in Ptch1+/− mice.
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The Hedgehog's tale: developing strategies for targeting cancer
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Understanding the Molecular Genetics of Basal Cell Carcinoma
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A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition
Biehs, B., Dijkgraaf, G. J. P., Piskol, R., Alicke, B., Boumahdi, S., Peale, F., Gould, S. E., & de Sauvage, F. J. (2018) · Nature · doi:10.1038/s41586-018-0596-y · Cited by 137
Metadata
- Authors
- Wang, G. Y., Wang, J., Mancianti, M.-L., & Epstein, E. H.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 19
- Issue
- 1
- Pages
- 114-124
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1970960957
- Cited by
- 226
- References
- 14
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, G. Y., Wang, J., Mancianti, M.-L., & Epstein, E. H. (2011). Basal Cell Carcinomas Arise from Hair Follicle Stem Cells in Ptch1+/− Mice. Cancer Cell. https://doi.org/10.1016/j.ccr.2010.11.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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