The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

Rodríguez-Rodríguez, Cristina, Telpoukhovskaia, Maria, Orvig, Chris·2012·Coordination Chemistry Reviews

Cites (325)

Items 201–324 of 324

  1. Alzheimer's disease: new approaches to drug discovery
    María Laura Bolognesi, Riccardo Matera, Anna Minarini, Michela Rosini, Carlo Melchiorre · 2009 · Current Opinion in Chemical Biology
  2. Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease
    Andrés Binolfi, Liliana Quintanar, Carlos W. Bertoncini, Christian Griesinger, Claudio O. Fernández · 2012 · Coordination Chemistry Reviews
  3. Nutritional Approaches to Modulate Oxidative Stress in Alzheimers Disease
    Chava B. Pocernich, Miranda L. Bader Lange, Rukhsana Sultana A, David Allan Butterfield · 2011 · Current Alzheimer Research
  4. Preparation and Study of New Poly‐8‐Hydroxyquinoline Chelators for an anti‐Alzheimer Strategy
    Céline Deraeve, Christophe Boldron, Alexandrine Maraval, Honoré Mazarguil, Heinz Gornitzka, Laure Vendier, Marguerite Pitié, Bernard Meunier · 2007 · Chemistry - A European Journal
  5. Copper, β-amyloid, and Alzheimer's disease: Tapping a sensitive connection
    Ashley Ian Bush, Colin Louis Masters, Rudolph E. Tanzi · 2003 · Proceedings of the National Academy of Sciences
  6. Antioxidant Vitamin Supplement Use and Risk of Dementia or Alzheimer's Disease in Older Adults
    Gray, Shelly L., Anderson, Melissa L., Crane, Paul K., Breitner, John C. S., McCormick, Wayne, Bowen, James D., Teri, Linda, Larson, Eric · 2008 · Journal of the American Geriatrics Society
  7. Multifunction of myricetin on Aβ: Neuroprotection via a conformational change of Aβ and reduction of Aβ via the interference of secretases
    Yoshiari Shimmyo, Takeshi Kihara, Akinori Akaike, Tetsuhiro Niidome, Hachiro Sugimoto · 2007 · Journal of Neuroscience Research
  8. The toxicology of Clioquinol☆
    Xinliang Mao, Aaron David Schimmer · 2008 · Toxicology Letters
  9. 6-Hydroxydopamine releases iron from ferritin and promotes ferritin-dependent lipid peroxidation
    Monteiro, Hugo P., Winterbourn, Christine C. · 1989 · Biochemical Pharmacology
  10. Sequestration of Copper from β-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents
    Wei‐Hui Wu, Peng Lei, Qian Rong Liu, Jia Hu, Adam P. Gunn, Mei‐Sha Chen, Yanfang Rui, Xiaoyang Su, Zuoping Xie, Yufen Zhao et al. · 2008 · Journal of Biological Chemistry
  11. Dopaminergic system and monoamine oxidase-B Activity in Alzheimer's disease
    Kari Juha Reinikainen, Leo Paljärvi, Toivo Halonen, Outi Malminen, Veli-Matti Kosma, Markku Laakso, Paavo Johannes Riekkinen · 1988 · Neurobiology of Aging
  12. Cleavage Agents for Soluble Oligomers of Amyloid β Peptides
    Junghun Suh, Sang‐Ho Yoo, Min Gyum Kim, Keunhong Jeong, Jae Young Ahn, Myoung‐soon Kim, Pil Seok Chae, Tae Yeon Lee, Jae-Hwa Lee, Jeongkuk Lee et al. · 2007 · Angewandte Chemie International Edition
  13. In Silico Predictions of Blood-Brain Barrier Penetration: Considerations to “Keep in Mind”
    Jay T. Goodwin, David E. Clark · 2005 · Journal of Pharmacology and Experimental Therapeutics
  14. Combating Alzheimer's Disease With Multifunctional Molecules Designed for Metal Passivation
    Harvey J. Schugar, David E. Green, Meryn L. Bowen, Lauren E. Scott, Tim Storr, Karin Böhmerle, Fancy C. Thomas, David D. Allen, Paul R. Lockman, Michael Merkel et al. · 2007 · Angewandte Chemie International Edition
  15. Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPVSIPQ prevention of ethanol-induced developmental toxicity
    Michael F. Wilkemeyer, Shao-yu Chen, Carrie E. Menkari, Douglas E. Brenneman, Kathleen K. Sulik, Michael E. Charness · 2003 · Proceedings of the National Academy of Sciences
  16. Effects of Cyclen and Cyclam on Zinc(II)- and Copper(II)-Induced Amyloid β-Peptide Aggregation and Neurotoxicity
    Tingting Chen, Xiaoyong Wang, Yafeng He, Changli Zhang, Ziyi Wu, Kuo Liao, Jianjun Wang, Zijian Guo · 2009 · Inorganic Chemistry
  17. Stabilities of 1,2-dimethyl-3-hydroxy-4-pyridinone chelates of divalent and trivalent metal ions
    Clarke, Eric T., Martell, Arthur E. · 1992 · Inorganica Chimica Acta
  18. Metal–Salen‐Base‐Pair Complexes Inside DNA: Complexation Overrides Sequence Information
    Guido H. Clever, Yvonne Söltl, Heather E. Burks, Werner Spahl, Thomas Carell · 2006 · Chemistry - A European Journal
  19. Tacrine-induced Reactive Oxygen Species in a Human Liver Cell Line: The Role of Anethole Dithiolethione as a Scavenger
    R. Osseni, CAROLINE DEBBASCH, M.O. Christen, Patrice Rat, Jean‐Michel Warnet · 1999 · Toxicology in Vitro
  20. Pittsburgh Compound B (11C-PIB) and Fluorodeoxyglucose (18 F-FDG) PET in Patients With Alzheimer Disease, Mild Cognitive Impairment, and Healthy Controls
    Davangere P. Devanand, Arthur Mikhno, Gregory H. Pelton, Katrina Cuasay, Gnanavalli Pradhaban, J.S. Dileep Kumar, Neil Upton, Robert Y. K. Lai, Roger N. Gunn, Vincenzo Libri et al. · 2010 · Journal of Geriatric Psychiatry and Neurology
  21. Novel Benzofuran Derivatives for PET Imaging of β-Amyloid Plaques in Alzheimer's Disease Brains
    Masahiro Ono, Hidekazu Kawashima, Akemi Nonaka, Tomoki Kawai, Mamoru Haratake, Hiroshi Mori, Mei‐Ping Kung, Hank F. Kung, Hideo Saji, Morio Nakayama · 2006 · Journal of Medicinal Chemistry
  22. Drug delivery strategies for Alzheimer's disease treatment
    Antonio Di Stefano, Antonio Iannitelli, Sara Laserra, Piera Sozio · 2011 · Expert Opinion on Drug Delivery
  23. IBOX(2-(4′-dimethylaminophenyl)-6-iodobenzoxazole): a ligand for imaging amyloid plaques in the brain
    Zhi‐Ping Zhuang, Mei‐Ping Kung, Catherine Hou, Karl Plöessl, Daniel Skovronsky, Tamar Gur, John Q. Trojanowski, Virginia M.‐Y. Lee, Hank F. Kung · 2001 · Nuclear Medicine and Biology
  24. Effects of Clioquinol on Metal-Triggered Amyloid-β Aggregation Revisited
    Mancino, Allana M., Hindo, Sarmad S., Kochi, Akiko, Lim, Mi Hee · 2009 · Inorganic Chemistry
  25. Site-Activated Chelators Targeting Acetylcholinesterase and Monoamine Oxidase for Alzheimer’s Therapy
    Hailin Zheng, Moussa B. H. Youdim, Mati Fridkin · 2010 · ACS Chemical Biology
  26. Myricetin: A Naturally Occurring Regulator of Metal‐Induced Amyloid‐β Aggregation and Neurotoxicity
    Alaina S. DeToma, Jung‐Suk Choi, Joseph J. Braymer, Mi Hee Lim · 2011 · ChemBioChem
  27. Alzheimer's disease and the amyloid cascade hypothesis: ten years on
    Bernd Sommer · 2002 · Current Opinion in Pharmacology
  28. Effect of metal ions on de novo aggregation of full-length prion protein
    Armin Giese, Johannes Levin, Uwe Bertsch, Hans A. Kretzschmar · 2004 · Biochemical and Biophysical Research Communications
  29. From Vasoactive Intestinal Peptide (VIP) Through Activity-Dependent Neuroprotective Protein (ADNP) to NAP: A View of Neuroprotection and Cell Division
    Illana Gozes, Inna Divinski, Inbar Pilzer, Mati Fridkin, Douglas E. Brenneman, Avron D. Spier · 2003 · Journal of Molecular Neuroscience
  30. Kinetics of interaction of metal ions with two tetraazatetraacetate macrocycles
    Stanisław P. Kasprzyk, Ralph G. Wilkins · 1982 · Inorganic Chemistry
  31. Glucose transport to the brain: A systems model
    Amina Ann Qutub, C. Anthony Hunt · 2005 · Brain Research Reviews
  32. Operative Strategy for Pheochromocytomas Localized by [i-131]-M-Iodobenzylguanidine Scintigraphy
    NW Thompson, I R Gough · 1984 · The Lancet
  33. Tocopherol (Vitamin E) in Alzheimer???s Disease and Other Neurodegenerative Disorders
    Karen Berman, Henry Brodaty · 2004 · CNS Drugs
  34. Development of Bifunctional Stilbene Derivatives for Targeting and Modulating Metal-Amyloid-β Species
    Joseph J. Braymer, Jung-Suk Choi, Alaina S. DeToma, Chen Wang, Kisoo Nam, Jeffrey W. Kampf, Ayyalusamy Ramamoorthy, Mi Hee Lim · 2011 · Inorganic Chemistry
  35. Inhibition of inducible nitric oxide synthase expression and cell death by (−)-epigallocatechin-3-gallate, a green tea catechin, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease
    Ji‐Seon Kim, Jong-Min Kim, O Jeong-Ja, Beom S. Jeon · 2010 · Journal of Clinical Neuroscience
  36. Effect of dietary quercetin on brain quercetin levels and the expression of antioxidant and Alzheimer's disease relevant genes in mice
    Patricia Huebbe, Anika Eva Wagner, Christine Boesch, Frederike Sellmer, Siegfried Wolffram, Gerald H Rimbach · 2009 · Pharmacological Research
  37. A Prochelator Activated by Hydrogen Peroxide Prevents Metal‐Induced Amyloid β Aggregation
    Marina G. Dickens, Katherine J. Franz · 2009 · ChemBioChem
  38. A Prochelator Activated by β-Secretase Inhibits Aβ Aggregation and Suppresses Copper-Induced Reactive Oxygen Species Formation
    Drew S. Folk, Katherine J. Franz · 2010 · Journal of the American Chemical Society
  39. Monoamine oxidase B (MAO B) inhibitor therapy in Parkinson's disease
    Joanna S. Fowler, Nora D. Volkow, Jean Logan, David J. Schlyer, Robert R MacGregor, G-J. Wang, A. P. Wolf, Naomi R. Pappas, David Alexoff, Colleen E. Shea et al. · 1993 · Neurology
  40. The Path from Anti Parkinson Drug Selegiline and Rasagiline to Multifunctional Neuroprotective Anti Alzheimer Drugs Ladostigil and M30
    Moussa B. H. Youdim · 2006 · Current Alzheimer Research
  41. Short-Term Supplementation with Plant Extracts Rich in Flavonoids Protect Nigrostriatal Dopaminergic Neurons in a Rat Model of Parkinson's Disease
    Krishna P. Datla, Virginia Zbarsky, Deepal Rai, Shabnam Parkar, Naomi Osakabe, Okezie I. Aruoma, David Trevor Dexter · 2007 · Journal of the American College of Nutrition
  42. The neuroprotective peptide NAP inhibits the aggregation of the beta-amyloid peptide
    Osnat Ashur‐Fabian, Yael Segal-Ruder, Ehud Skutelsky, Douglas E. Brenneman, Ruth A. Steingart, Eliezer Giladi, Illana Gozes · 2003 · Peptides
  43. Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload
    Haozhou Jiang, Zhuo Luan, Jun Wang, J XIE · 2006 · Neurochemistry International
  44. Development of a PET/SPECT Agent for Amyloid Imaging in Alzheimer's Disease
    Yanming Wang, William Edward Klunk, Manik L. Debnath, Guo-Feng Huang, Daniel P. Holt, Li Shao, Chester A. Mathis · 2004 · Journal of Molecular Neuroscience
  45. Systemically administered d-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents
    Giuseppe Battaglia, Mauro Francesco La Russa, Valeria Bruno, Loredana Arenare, R. Ippolito, Agata Copani, Francesco Paolo Bonina, Ferdinando Nicoletti · 2000 · Brain Research
  46. Synthesis of glycosyl derivatives as dopamine prodrugs: interaction with glucose carrier GLUT-1Electronic supplementary information (ESI) available: experimental details for the preparation of all derivatives and biological assays. See http://www.rsc.org/suppdata/ob/b2/b212066f/
    Caridad I Fernández, Ofelia Nieto, José Angel Fontenla, Emilia Rivas, Maria L. DE CEBALLOS, Alfonso Fernández‐Mayoralas · 2003 · Organic & Biomolecular Chemistry
  47. NUTRITIONAL PROPERTIES AND SIGNIFICANCE OF VITAMIN GLYCOSIDES
    Jesse F. Gregory · 1998 · Annual Review of Nutrition
  48. Thioflavin Derivatives as Markers for Amyloid‐β Fibrils: Insights into Structural Features Important for High‐Affinity Binding
    Leuma Yona, Rodrigue, Mazères, Serge, Faller, Peter, Gras, Emmanuel · 2008 · ChemMedChem
  49. Toward a Rational Design of Multitarget-Directed Antioxidants: Merging Memoquin and Lipoic Acid Molecular Frameworks
    María Laura Bolognesi, Andrea Cavalli, Christian Bergamini, Romana Fato, Giorgio Lenaz, Michela Rosini, Manuela Bartolini, Vincenza Andrisano, Carlo Melchiorre · 2009 · Journal of Medicinal Chemistry
  50. The Environment of the Lipoxygenase Iron Binding Site Explored with Novel Hydroxypyridinone Iron Chelators
    Abeysinghe, Rajeewa D., Roberts, Pamela J., Cooper, Chris E., MacLean, Kirsteen H., Hider, Robert C., Porter, John B. · 1996 · Journal of Biological Chemistry
  51. Design, Synthesis, and Evaluation of Novel 2-Substituted 3-Hydroxypyridin-4-ones: Structure−Activity Investigation of Metalloenzyme Inhibition by Iron Chelators
    Zu Dong Liu, Reem Kayyali, Robert C. Hider, John B. Porter, Anthony E. Theobald · 2002 · Journal of Medicinal Chemistry
  52. The origin of the prion agent of kuru: molecular and biological strain typing
    Jonathan D. F. Wadsworth, Susan Joiner, Jacqueline M. Linehan, Emmanuel A. Asante, Sebastian Brandner, John Collinge · 2008 · Philosophical Transactions of the Royal Society B Biological Sciences
  53. Green tea polyphenol (−)-epigallocatechin-3-gallate protects rat PC12 cells from apoptosis induced by serum withdrawal
    Silvia A. Mandel, Lydia Reznichenko, Tamar Amit, Moussa B. H. Youdim · 2003 · Neurotoxicity Research
  54. N-Aryl-substituted 3-(β-D-glucopyranosyloxy)-2-methyl-4(1H)-pyridinones as agents for Alzheimer's therapy
    Scott, Lauren E., Telpoukhovskaia, Maria, Rodríguez-Rodríguez, Cristina, Merkel, Michael, Bowen, Meryn L., Page, Brent D. G., Green, David E., Storr, Tim, Thomas, Fancy, Allen, David D. et al. · 2011 · Chem. Sci.
  55. Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entity
    María Laura Bolognesi, Manuela Bartolini, Andrea Tarozzi, Fabiana Morroni, Federica Lizzi, Andrea Milelli, Anna Minarini, Michela Rosini, Patrizia Hrelia, Vincenza Andrisano et al. · 2010 · Bioorganic & Medicinal Chemistry Letters
  56. Rational Design of Amyloid Binding Agents Based on the Molecular Rotor Motif
    Jeyanthy Sutharsan, Marianna Dakanali, Christina C. Capule, Mark A. Haidekker, Jerry Yang, Emmanuel A. Theodorakis · 2009 · ChemMedChem
  57. Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, and cholinergic and glutamatergic action for neurodegenerative diseases
    Cornelis J. Van der Schyf, Shunit Gal, Werner J. Geldenhuys, Moussa B. H. Youdim · 2006 · Expert Opinion on Investigational Drugs
  58. Iron Chelators as Potential Therapeutic Agents for Parkinsons Disease
    Carlos Perez, Yong Tong, Maolin Guo · 2008 · Current Bioactive Compounds
  59. Metal-protein attenuating compounds and Alzheimer’s disease
    Craig William Ritchie, Ashley Ian Bush, Colin Louis Masters · 2004 · Expert Opinion on Investigational Drugs
  60. 13- and 14-membered macrocyclic ligands containing methylcarboxylate or methylphosphonate pendant arms: Chemical and biological evaluation of their 153Sm and 166Ho complexes as potential agents for therapy or bone pain palliation
    Fernanda Marques, Lurdes Gano, Maria Paula Cabral Campello, Sara Lacerda, Isabel Santos, Luı́s M. P. Lima, Judite Costa, Patrícia Antunes, Rita Delgado · 2006 · Journal of Inorganic Biochemistry
  61. Parkinson's Disease and Tea: A Quantitative Review
    José Luis Barranco Quintana, Mohamed Farouk Allam, Amparo Serrano del Castillo, Rafael Fernández‐Crehuet Navajas · 2009 · Journal of the American College of Nutrition
  62. The effect of N-alkyl modification on the antimalarial activity of 3- hydroxypyridin-4-one oral iron chelators
    C Hershko, EN Theanacho, Dan T. Spira, HH Peter, Paul S. Dobbin, Robert C. Hider · 1991 · Blood
  63. A Cysteine-Based Tripodal Chelator with a High Affinity and Selectivity for Copper(I)
    Anaïs M. Pujol, Christelle Gateau, Colette Lebrun, Pascale Delangle · 2009 · Journal of the American Chemical Society
  64. Coordination of zinc ions to the key proteins of neurodegenerative diseases: Aβ, APP, α-synuclein and PrP
    Vello Tõugu, Peep Palumaa · 2011 · Coordination Chemistry Reviews
  65. In vitro studies of 3-hydroxy-4-pyridinones and their glycosylated derivatives as potential agents for Alzheimer's disease
    David E. Green, Meryn L. Bowen, Lauren E. Scott, Tim Storr, Michael Merkel, Karin Böhmerle, Katherine H. Thompson, Brian O. Patrick, Harvey J. Schugar, Chris Orvig · 2009 · Dalton Transactions
  66. Intra- and extra-dopamine-synaptosomal localization of monoamine oxidase in striatal homogenates from four species
    Anders Stenström, John Hardy, Lars Oreland · 1987 · Biochemical Pharmacology
  67. Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents
    Céline Deraeve, Marguerite Piti, Honor? Mazarguil, Bernard Meunier · 2007 · New Journal of Chemistry
  68. Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration
    Wen Zhu, Xuping Li, Wenjie Xie, Feifei Luo, Deepinder Kaur, Julie Kay Andersen, Joseph J. Jankovic, Weidong Le · 2009 · Neurobiology of Disease
  69. Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons
    Zheng, Hailin, Youdim, Moussa B.H., Weiner, Lev M., Fridkin, Mati · 2005 · Biochemical Pharmacology
  70. Effect of Zinc (II) on the interactions of bovine serum albumin with flavonols bearing different number of hydroxyl substituent on B-ring
    Shuhong Cao, Xinyu Jiang, Jingwen Chen · 2009 · Journal of Inorganic Biochemistry
  71. Recent Development of Bifunctional Small Molecules to Study Metal‐Amyloid‐<i>β</i> Species in Alzheimer′s Disease
    Braymer, Joseph J., DeToma, Alaina S., Choi, Jung-Suk, Ko, Kristin S., Lim, Mi Hee · 2011 · International Journal of Alzheimer’s Disease
  72. Dual effects of curcumin on neuronal oxidative stress in the presence of Cu(II)
    Han‐Chang Huang, Changjun Lin, Wenjuan Liu, Rui-Rui Jiang, Zhao-Feng Jiang · 2011 · Food and Chemical Toxicology
  73. Hepatotoxicity of tetrahydroaminoacridine in isolated rat hepatocytes: Effect of glutathione and vitamin E
    Peter Dogterom, J. Fred Nagelkerke, Gerard J. Mulder · 1988 · Biochemical Pharmacology
  74. Two Functions, One Molecule: A Metal‐Binding and a Targeting Moiety to Combat Alzheimer's Disease
    Hureau, Christelle, Sasaki, Isabelle, Gras, Emmanuel, Faller, Peter · 2010 · ChemBioChem
  75. A Novel Iron-Chelating Derivative of the Neuroprotective Peptide NAPVSIPQ Shows Superior Antioxidant and Antineurodegenerative Capabilities
    Dan Blat, Lev M. Weiner, Moussa B. H. Youdim, Mati Fridkin · 2007 · Journal of Medicinal Chemistry
  76. Structure/iron binding activity of 1-hydroxypyrid-2-one chelators intended for clinical use
    George J. Kontoghiorghes · 1987 · Inorganica Chimica Acta
  77. Prion Protein and Metal Interaction: Physiological and Pathological Implications
    Neena Singh, Dola Das, Ajay Vikram Singh, Maradumane L. Mohan · 2010 · Caister Academic Press eBooks
  78. DNA damage in mouse lymphocytes exposed to curcumin and copper
    Patricia Urbina-Cano, Lucina Bobadilla‐Morales, Mario Alberto Ramírez-Herrera, Jorge Román Corona‐Rivera, María Luisa Mendoza-Magaña, Rogelio Troyo‐Sanromán, Alfredo Corona‐Rivera · 2006 · Journal of Applied Genetics
  79. Two pyridine derivatives as potential Cu( ii ) and Zn( ii ) chelators in therapy for Alzheimer's disease
    Andrea Lakatos, Éva Zsigó, Dominik Hollender, Nóra V. May, Lívia Fülöp, Dóra Simon, Zsolt Bozsó, Tamás Kiss · 2009 · Dalton Transactions
  80. Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6‐Hydroxydopamine
    Michael Gassen, Aviva Gross, Moussa B. H. Youdim · 1998 · Movement Disorders
  81. Synthesis, physical–chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer’s disease
    Alessandra Gaeta, Francisco Molina‐Holgado, Xiao Le Kong, Sarah Salvage, Sarah Fakih, Paul T. Francis, Robert J. Williams, Robert C. Hider · 2010 · Bioorganic & Medicinal Chemistry
  82. Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126
    Masahiro Kawahara, H. Koyama, Tetsuya Nagata, Yutaka Sadakane · 2011 · Metallomics
  83. Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer's therapy
    Tim Storr, Lauren E. Scott, Meryn L. Bowen, David E. Green, Katherine H. Thompson, Harvey J. Schugar, Chris Orvig · 2009 · Dalton Transactions
  84. Prions and manganese: A maddening beast
    David Ross Brown · 2010 · Metallomics
  85. Iron(III)-chelating resins. 3. Synthesis, iron(III)-chelating properties, and in vitro antibacterial activity of compounds containing 3-hydroxy-2-methyl-4(1H)-pyridinone ligands
    Min Hua Feng, L. van der Does, Adriaan Bantjes · 1993 · Journal of Medicinal Chemistry
  86. Detection of Amyloid Plaques by Radioligands for Aβ40 and Aβ42: Potential Imaging Agents in Alzheimer's Patients
    Mei‐Ping Kung, Daniel Skovronsky, Catherine Hou, Zhi‐Ping Zhuang, Tamar Gur, Bin Zhang, John Q. Trojanowski, Virginia M.‐Y. Lee, Hank F. Kung · 2003 · Journal of Molecular Neuroscience
  87. Synthesis and characterization of IMPY derivatives that regulate metal-induced amyloid-β aggregation
    Choi, Jung-Suk, Braymer, Joseph J., Park, Se Kyung, Mustafa, Shaik, Chae, Junghyun, Lim, Mi Hee · 2011 · Metallomics
  88. Aging, Amyloid, and Alzheimer's Disease
    Dennis J. Selkoe · 1989 · New England Journal of Medicine
  89. A study on the mimics of Cu–Zn superoxide dismutase with high activity and stability: two copper( ii ) complexes of 1,4,7-triazacyclononane with benzimidazole groups
    Qingxiang Li, Qin‐Hui Luo, Yizhi Li, Meng‐Chang Shen · 2004 · Dalton Transactions
  90. The rich electrochemistry and redox reactions of the copper sites in the cellular prion protein
    Feimeng Zhou, Glenn L. Millhauser · 2012 · Coordination Chemistry Reviews
  91. Multifunctional Antioxidants for the Treatment of Age-Related Diseases
    Hong‐Xia Jin, James Randazzo, Peng Zhang, Peter F. Kador · 2010 · Journal of Medicinal Chemistry
  92. Orally Active Multi-Functional Antioxidants Delay Cataract Formation in Streptozotocin (Type 1) Diabetic and Gamma-Irradiated Rats
    James Randazzo, Peng Zhang, Jun Makita, Karen Blessing, Peter F. Kador · 2011 · PLoS ONE
  93. New analgesic and antiinflammatory agents 4(1H)-pyridinone derivatives
    Gülcan Öztürk, DİLEK DEMİR EROL, Mutlu Dilsiz Aytemir, Tayfun I. Uzbay · 2002 · European Journal of Medicinal Chemistry
  94. Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease
    Lauren E. Scott, Brent D. G. Page, Brian O. Patrick, Chris Orvig · 2008 · Dalton Transactions
  95. Manganese chelation therapy extends survival in a mouse model of M1000 prion disease
    Marcus W. Brazier, Irene Volitakis, Magda Kvasnicka, Anthony Robert White, John R. Underwood, Jason E. Green, Sen Han, Andrew Francis Hill, Colin Louis Masters, Steven John Collins · 2010 · Journal of Neurochemistry
  96. 3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl- 4(1H)-pyridinone: Potent Inhibitors of Lipid Peroxidation and Cell Toxicity
    David Bebbington, Nathaniel J. T. Monck, Suneel Gaur, Alan M. Palmer, Karen R. Benwell, Victoria L. Harvey, Craig S. Malcolm, Richard H. P. Porter · 2000 · Journal of Medicinal Chemistry
  97. Neuroprotection by propargylamines in Parkinson’s disease: intracellular mechanism underlying the anti-apoptotic function and search for clinical markers
    Makoto Naoi, W. Maruyama, Hong Liang Yi, Yukihiro Akao, Y. Yamaoka, Masayo Shamoto‐Nagai · 2007 · Springer eBooks
  98. Fragmentation and dimerization of copper-loaded prion protein by copper-catalysed oxidation
    Noriyuki Shiraishi, Yoko Inai, Wenxiang Bi, Morimitsu Nishikimi · 2005 · Biochemical Journal
  99. Effect of Copper and Manganese on the de Novo Generation of Protease-Resistant Prion Protein in Yeast Cells
    Carina Treiber, Andreas Simons, Gerd Multhaup · 2006 · Biochemistry
  100. The copper chelator, D-penicillamine, does not attenuate MPTP induced dopamine depletion in mice
    Moussa B. H. Youdim, Edna Grünblatt, Silvia A. Mandel · 2006 · Journal of Neural Transmission
  101. Coordination Compounds as Synthetic Building Blocks
    Yitzhak Tor · 2002 · Synlett
  102. 1,1′-Xylyl bis-1,4,8,11-tetraaza cyclotetradecane: A new potential copper chelator agent for neuroprotection in Alzheimer’s disease. Its comparative effects with clioquinol on rat brain copper distribution
    Vincent Moret, Younès Laras, Nicolas Pietrancosta, Cédrik Garino, Gilles Quéléver, Amandine Rolland, B. Mallet, Jean-Chrétien Norreel, Jean‐Louis Kraus · 2006 · Bioorganic & Medicinal Chemistry Letters
  103. Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers
    Mingzhang Gao, Min Wang, Kathy D. Miller, George W. Sledge, Gary D. Hutchins, Qi‐Huang Zheng · 2006 · Bioorganic & Medicinal Chemistry Letters
  104. Synthesis and iron(III) binding properties of 3-hydroxypyrid-4-ones derived from kojic acid
    John Josef Molenda, Mark A. Basinger, Timothy P. Hanusa, Mark Martin Jones · 1994 · Journal of Inorganic Biochemistry
  105. Beyond symptomatic therapy: a re-examination of acetylcholinesterase inhibitors in Alzheimer’s disease
    Norman R. Relkin · 2007 · Expert Review of Neurotherapeutics
  106. Synthesis and evaluation of peptidic metal chelators for neuroprotection in neurodegenerative diseases
    Hailin Zheng, Moussa B. H. Youdim, Lev M. Weiner, Mati Fridkin · 2005 · Journal of Peptide Research
  107. The chelation targeting metal–Aβ40 aggregates may lead to formation of Aβ40 oligomers
    Zhang, Yong, Chen, Li-Yuan, Yin, Wen-Xing, Yin, Jun, Zhang, Shi-Bing, Liu, Chang-Lin · 2011 · Dalton Transactions
  108. The Parkinson's disease market
    Trung Huynh · 2011 · Nature Reviews Drug Discovery
  109. Stilbene derivatives that are colchicine site microtubule inhibitors have antileukemic activity and minimal systemic toxicity
    Thai M. Cao, David Durrant, Ashutosh Tripathi, Jihua Liu, Schickwann Tsai, Glen E. Kellogg, Daniele Simoni, Ray M. Lee · 2008 · American Journal of Hematology
  110. Neuropeptides and Neuronal Survival: Neuroprotective Strategy for Alzheimer's Diseasea
    Illana Gozes, Amos Bardea, Mordechai Bechar, O. PEARL, Ayelet Reshef, Rachel Zamostiano, Ariane Davidson, Sarah Rubinraut, Eliezer Giladi, Mati Fridkin et al. · 1997 · Annals of the New York Academy of Sciences
  111. Complexation of Iron with the Orally Active Decorporation Drug L1 (3-Hydroxy-1,2-Dimethyl-4-Pyridinone)
    Martha A. Kline, Chris Orvig · 1992 · Clinical Chemistry
  112. Novel neuroprotective neurotrophic NAP analogs targeting metal toxicity and oxidative stress: potential candidates for the control of neurodegenerative diseases
    Hailin Zheng, Dan Blat, Mati Fridkin · 2006 · Springer eBooks
  113. Preparation of Cyclo‐Phen‐Type Ligands: Chelators of Metal Ions as Potential Therapeutic Agents in the Treatment of Neurodegenerative Diseases
    Christophe Boldron, Ingrid Van der Auwera, Céline Deraeve, Heinz Gornitzka, Stefaan Wera, Marguerite Pitié, Fred VAN LEUVEN, Bernard Meunier · 2005 · ChemBioChem
  114. Injections of the neuroprotective peptide NAP to newborn mice attenuate head-injury-related dysfunction in adults
    Roy Zaltzman, Sara M. Beni, Eliezer Giladi, Albert Pinhasov, Ruth A. Steingart, Jacob Romano, Esther Shohami, Illana Gozes · 2003 · Neuroreport
  115. Prodrug and covalent linker strategies for the solubilization of dual-Action antioxidants/Iron chelators
    David Bebbington, Claire E. Dawson, Suneel Gaur, John Spencer · 2002 · Bioorganic & Medicinal Chemistry Letters
  116. Identification of multifunctional small molecule-based reversible monoamine oxidase inhibitors
    Werner J. Geldenhuys, Kristin S. Ko, Hilary Stinnett, Cornelis J. Van der Schyf, Mi Hee Lim · 2011 · MedChemComm
  117. Competition between iron(III)-selective chelators and zinc-finger domains for zinc(II)
    Robert C. Hider, Doug Bittel, Glen K. Andrews · 1999 · Biochemical Pharmacology
  118. Therapeutic targets in the biology of Alzheimerʼs disease
    Ashley Ian Bush · 2001 · Current Opinion in Psychiatry
  119. In silico strategies for the selection of chelating compounds with potential application in metal-promoted neurodegenerative diseases
    Cristina Rodríguez‐Rodríguez, Albert Rimola, Jorge Alí‐Torres, Mariona Sodupe, Pilar Gonzalez-Duarte · 2010 · Journal of Computer-Aided Molecular Design
  120. Effect of desferrioxamine and hydroxypyridones on hemopoietic progenitors and neuroectodermal tumor cells
    Fabio Stefano Timeus, Paola Valle, Nicoletta Crescenzio, Luciano Ruggieri, Paolo Rosso, Giovanni Luca Pagliardi, Luca Cordero di Montezemolo, Vilma Gabutti, Ugo Ramenghi · 1994 · American Journal of Hematology
  121. The Olivieri Case
    G Constantinou, Stavros Melides, B. Modell · 2003 · New England Journal of Medicine
  122. Corrigendum to “A new strategy to combat Alzheimer’s disease. Combining radical-scavenging potential with metal-protein-attenuating ability in one molecule”
    Hong‐Fang Ji, Hong‐Yu Zhang · 2004 · Bioorganic & Medicinal Chemistry Letters
  123. What makes the best medical ethics journal? A North American perspective
    Julian Savulescu, Adrian M. Viens · 2005 · Journal of Medical Ethics
  124. Untitled work
    2001 · 10.1002/1521-3773(20010618)40:12