Effects of Clioquinol on Metal-Triggered Amyloid-β Aggregation Revisited
Abstract
Amyloid-beta (Abeta) plaques are largely associated with the neuropathogenesis of Alzheimer's disease (AD). Metal ions such as Cu(II) and Zn(II) have been implicated as contributors to their formation and deposition. Metal chelators have been used to modulate metal-induced Abeta aggregation. The bidentate ligand clioquinol (CQ) presents an effective influence on metal-involved Abeta aggregation, which has been explained through its metal chelation and is generally monitored by fluorescence and turbidity assays in vitro. The studies herein, however, suggest that the effects of CQ on metal-driven Abeta aggregation may not be visualized accurately by both assays. Subsequently, the present work demonstrates that CQ is able to chelate metal ions from metal-Abeta species and to assist, in part, in the disaggregation of Abeta aggregates, but it could not completely hinder the progression of Abeta aggregation.
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Addition of CQ to Aβ42 fibrils in presence of Cu2+ leads to marked cell toxicity, likely due to the ability of CQ to disaggregate Aβ fibrils.
“As expected, addition of CQ to Aβ42 fibrils in presence of Cu2+ leads to marked cell toxicity (Figure 11, lane 12), likely due to the ability of CQ to disaggregate Aβ fibrils.96”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ<sub>42</sub>Peptide (2012) · cites this paper as [96]
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- Authors
- Mancino, A. M., Hindo, S. S., Kochi, A., & Lim, M. H.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Lim, Mi Hee
- ORCID
- Lim, Mi Hee
- Venue
- Inorganic Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-09-23
- Volume
- 48
- Issue
- 20
- Pages
- 9596-9598
- ISSN
- 0020-1669 (ISSN-L)
- 1520-510X
- OpenAlex
- W2002754698
- Cited by
- 102
- References
- 13
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 9 · 2016: 5 · 2015: 6 · 2014: 9 · 2013: 9 · 2012: 11
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Inorganic Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- clioquinol, amyloid-beta aggregation, Alzheimer's disease, metal chelation, copper(II), zinc(II), amyloid plaques, aggregation and disaggregation
- MeSH terms
- Alzheimer Disease, Chelating Agents, Copper, Humans, Clioquinol, Metals, Solubility, Zinc, Amyloid beta-Peptides
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