The chelation targeting metal–Aβ40 aggregates may lead to formation of Aβ40 oligomers

Zhang, Yong; Chen, Li-Yuan; Yin, Wen-Xing; Yin, Jun; Zhang, Shi-Bing; Liu, Chang-Lin

doi:10.1039/c1dt00020a

Cited by 26Alzheimer's disease research and treatmentsMolecular Sensors and Ion DetectionLuminescence and Fluorescent Materials

The chelation targeting metal–Aβ40 aggregates may lead to formation of Aβ40 oligomers

Zhang, Yong, Chen, Li-Yuan, Yin, Wen-Xing, Yin, Jun, Zhang, Shi-Bing, Liu, Chang-Lin·2011·Dalton Transactions

DOI 10.1039/c1dt00020a

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Abstract

The fluorescent chelator (FC-1) was designed by combining a metal-chelating unit and a ThT-based Aβ aggregate-binding fluorescent unit. FC-1 is a cell membrane-penetrable chelator with a moderate chelation ability to Cu(2+) and Zn(2+) and can target metal-Aβ40 aggregates. Treatment with FC-1 led to enhanced cytotoxicity of the aggregates, because the aggregates were converted into a pool of oligomers.

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Two approaches have been pursued in BFC design: direct incorporation of metal-binding atom donors into the structural framework of an Aβ-interacting compound, and linking the metal-chelating and Aβ-binding molecular fragments.
“In this context, two approaches have been pursued in BFC design. 31,49–58 One strategy is based on the direct incorporation of metal-binding atom donors into the structural framework of an Aβ-interacting compoud (Scheme 1, approach A), and the other involves linking the metal-chelating and Aβ-binding molecular fragments (Scheme 1, approach B).”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [53]
Other reported BFCs have employed benzothiazole fragments as amyloid-binding motifs, but no binding affinities for the Aβ species have been measured for those systems.
“While other reported BFCs have employed benzothiazole fragments as amyloid-binding motifs, no binding affinities for the Aβ species have been measured for those systems.49,53,54”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [53]

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Authors: Zhang, Y., Chen, L.-Y., Yin, W.-X., Yin, J., Zhang, S.-B., & Liu, C.-L.
Affiliations: Central China Normal University (CN)
ORCID: Zhang, Yong
Yin, Jun
Zhang, Shi-Bing
Venue: Dalton Transactions
Publisher: Royal Society of Chemistry (RSC)
Published: 2011
Volume: 40
Issue: 18
Pages: 4830
ISSN: 1477-9226 (ISSN-L)
1477-9234
DOI: 10.1039/c1dt00020a
OpenAlex: W2144307327
Semantic Scholar: b8b6c48abe4d3e12937b904e9fee4fe1b75462f4
Cited by: 26
References: 25
Citations by year: 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 5
FWCI: 1.74
Type: journal article
Language: en
Open access: closed
Locations: Dalton Transactions (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Keywords: Aβ40, copper(II) chelation, amyloid aggregates, oligomerization, cytotoxicity, Alzheimer's disease
MeSH terms: Chelating Agents, Copper, HeLa Cells, Humans, Hydrogen-Ion Concentration, Metals, Molecular Conformation, Peptide Fragments, Zinc, Amyloid beta-Peptides, Coordination Complexes

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The chelation targeting metal–Aβ40 aggregates may lead to formation of Aβ40 oligomers

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