Cited by 49Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesMolecular Sensors and Ion Detection

Two Functions, One Molecule: A Metal‐Binding and a Targeting Moiety to Combat Alzheimer's Disease

Hureau, Christelle, Sasaki, Isabelle, Gras, Emmanuel, Faller, Peter·2010·ChemBioChem

Abstract

Merging pharmacophores: Aggregation of the peptide amyloid-β (Aβ) is responsible for the development of Alzheimer's disease. Metal ions bound to Aβ can promote aggregation and oxidative stress, and can thus have a detrimental effect. Disruption of these processes with chelators, as well as targeting these chelators towards Aβ aggregates is therefore a promising strategy.

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Crossref · 10.1002/cbic.201000102

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23 of 23 references verified0 citation errors · 0 not checkable

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  • Two approaches have been pursued in BFC design: direct incorporation of metal-binding atom donors into the structural framework of an Aβ-interacting compound, and linking the metal-chelating and Aβ-binding molecular fragments.

    “In this context, two approaches have been pursued in BFC design. 31,49–58 One strategy is based on the direct incorporation of metal-binding atom donors into the structural framework of an Aβ-interacting compoud (Scheme 1, approach A), and the other involves linking the metal-chelating and Aβ-binding molecular fragments (Scheme 1, approach B).”

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Authors
Hureau, C., Sasaki, I., Gras, E., & Faller, P.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Faller, Peter
Venue
ChemBioChem
Publisher
Wiley
Published
2010-04-27
Volume
11
Issue
7
Pages
950-953
ISSN
  • 1439-4227 (ISSN-L)
  • 1439-7633
OpenAlex
W2100621472
Cited by
49
References
23
Citations by year
2023: 2 · 2021: 2 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 10
FWCI
5.63
Type
journal article
Language
en
Open access
closed
Locations
  • ChemBioChem (publishedVersion)
  • PubMed (publishedVersion)
Funders
Agence Nationale de la Recherche
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Keywords
Alzheimer's disease, amyloid-beta aggregation, metal ions, metal chelators, metal-binding peptides, targeting moieties, oxidative stress
MeSH terms
Alzheimer Disease, Chelating Agents, Metals, Amyloid beta-Peptides, Oxidative Stress, Amyloid Precursor Protein Secretases

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