A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

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Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

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Nucleotide deficiency promotes genomic instability in early stages of cancer development

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Advanced pancreatic carcinoma: current treatment and future challenges

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Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

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How the Fanconi Anemia Pathway Guards the Genome

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Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

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The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

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Characterization of the recombination activities of the Entamoeba histolytica Rad51 recombinase

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Unscheduled MRE11 activity triggers cell death but not chromosome instability in polymerase eta-depleted cells subjected to UV irradiation

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APLF facilitates interstrand DNA crosslink repair and replication fork protection to confer cisplatin resistance

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RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes

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Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers

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RNF20-mediated H2B monoubiquitination protects stalled forks from degradation and promotes fork restart

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What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses

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MT1-MMP-dependent ECM processing regulates laminB1 stability and mediates replication fork restart

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Moving beyond PARP Inhibition: Current State and Future Perspectives in Breast Cancer

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RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair

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Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells

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Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia

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FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine

Peña-Gómez, M. J., Moreno-Gordillo, P., Narmontė, M., García-Calderón, C. B., Rukšėnaitė, A., Klimašauskas, S., & Rosado, I. V. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04952-0 · Cited by 12

Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells

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SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability

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Caffeine Has a Synergistic Anticancer Effect with Cisplatin via Inhibiting Fanconi Anemia Group D2 Protein Monoubiquitination in Hepatocellular Carcinoma Cells

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A new road to cancer-drug resistance

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Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway

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Homologous recombination defects and how they affect replication fork maintenance

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RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease

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Role of HP1β during spermatogenesis and DNA replication

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The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery

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Deficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination

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Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex

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Safeguarding genome stability: RASSF1A tumor suppressor regulates BRCA2 at stalled forks

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DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfaces

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CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection

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Deregulated protein homeostasis constrains fetal hematopoietic stem cell pool expansion in Fanconi anemia

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RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication

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A RAD18–UBC13–PALB2–RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells

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The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links

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Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress

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Regulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3

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Mitomycin C reduces abundance of replication forks but not rates of fork progression in primary and transformed human cells

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TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A

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PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair

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Impact of Chromatin Dynamics and DNA Repair on Genomic Stability and Treatment Resistance in Pediatric High-Grade Gliomas

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Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinomaPreprint

Caeiro, L. D., Nakata, Y., Borges, R. L., Zha, M., Garcia-Martinez, L., Bañuelos, C. P., Stransky, S., Liu, T., Chan, H. L., Brabson, J., et al. (2024) · Genes & Development · doi:10.1101/gad.351408.123 · Cited by 11

Emerging strategies to overcome PARP inhibitors' resistance in ovarian cancer

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HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells

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DNA repair pathways in ovarian cancer: Implications for therapy and resistance

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Clinical application of PARP inhibitors and emerging strategies to overcome resistance: a pan-cancer perspective

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UBE2T resolves transcription-replication conflicts and protects common fragile sites in primordial germ cells

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Degradation of Mrc1 promotes recombination-mediated restart of stalled replication forks

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Never tear us a-PARP: Dealing with DNA lesions during mitosis

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Expression, Purification, and Biochemical Evaluation of Human RAD51 Protein

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Prostate cancer in the era of “Omic” medicine: recognizing the importance of DNA damage repair pathways

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BRCA1 identified as a modulator of temozolomide resistance in P53 wild-type GBM using a high-throughput shRNA-based synthetic lethality screening.

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The RECQL helicase prevents replication fork collapse during replication stress

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Poly-ADP-ribosyl-polymerase inhibitor resistance mechanisms and their therapeutic implications

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DNA Damage Response during Replication Correlates with CIN70 Score and Determines Survival in HNSCC Patients

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Spatial separation of replisome arrest sites influences homologous recombination quality at a Tus/Ter-mediated replication fork barrier

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How to sensitize glioblastomas to temozolomide chemotherapy: a gap-centered view

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Bioactivated Glucoraphanin Improves Cell Survival, Upregulating Phospho-AKT, and Modulates Genes Involved in DNA Repair in an In Vitro Alzheimer’s Disease Model: A Network-Transcriptomic Analysis

Minuti, A., Mazzon, E., Iori, R., Chiricosta, L., & Artimagnella, O. (2024) · Nutrients · doi:10.3390/nu16234202 · Cited by 9

A medicinal chemistry perspective on ATR: Current status and future directions

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Regulatory processes that maintain or alter ribosomal DNA stability during the repair of programmed DNA double-strand breaks

Sasaki, M., & Kobayashi, T. (2022) · Genes & Genetic Systems · doi:10.1266/ggs.22-00046 · Cited by 9

The linker histone H1–BRCA1 axis is a crucial mediator of replication fork stability

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Human HELQ regulates DNA end resection at DNA double-strand breaks and stalled replication forks

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R-loop functions in Brca1 -associated mammary tumorigenesis

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Biochemical Activities and Genetic Functions of the Drosophila melanogaster Fancm Helicase in DNA Repair

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Genetic and biochemical evidences reveal novel insights into the mechanism underlying Saccharomyces cerevisiae Sae2-mediated abrogation of DNA replication stress

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Relevance of poly (ADP-ribose) polymerase inhibitors in prostate cancer

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Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function

Špı́rek, M., Taylor, M. R. G., Beláň, O., Boulton, S. J., & Krejčí, L. (2021) · Nature Communications · doi:10.1038/s41467-021-25830-x · Cited by 10

Identification of Nanog as a novel inhibitor of Rad51

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Pre-Existing and Acquired Resistance to PARP Inhibitor-Induced Synthetic Lethality

Le, B. V., Podszywalow‐Bartnicka, P., Piwocka, K., & Skórski, T. (2022) · Cancers · doi:10.3390/cancers14235795 · Cited by 9

Do p53 stress responses impact organismal aging?

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Nucleases and Co-Factors in DNA Replication Stress Responses

Nickoloff, J. A., Sharma, N., Taylor, L. E., Allen, S. J., & Hromas, R. (2022) · DNA · doi:10.3390/dna2010006 · Cited by 9

FANCD2 Alleviates Physiologic Replication Stress in Fetal Liver HSCPreprint

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A clickable melphalan for monitoring DNA interstrand crosslink accumulation and detecting ICL repair defects in Fanconi anemia patient cells

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CSB and SMARCAL1 compete for RPA32 at stalled forks and differentially control the fate of stalled forks in BRCA2-deficient cells

Batenburg, N. L., Sowa, D. J., Walker, J. R., Andres, S. N., & Zhu, X. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae154 · Cited by 8

The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway

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Mechanism of Action of PARP Inhibitors

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Homologous recombination deficiency (HRD) diagnostics: underlying mechanisms and new perspectives

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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

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FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells

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Transcriptome analysis during 4-vinylcyclohexene diepoxide exposure-induced premature ovarian insufficiency in mice

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Clinical relevance of double heterozygosity revealed by next-generation sequencing of homologous recombination repair pathway genes in South African breast cancer patients

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