The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Cancer Genetics and Epigenetics: Two Sides of the Same Coin?
Open accessAbstract
Summary Epigenetic and genetic alterations have long been thought of as two separate mechanisms participating in carcinogenesis. A recent outcome of whole exome sequencing of thousands of human cancers has been the unexpected discovery of many inactivating mutations in genes that control the epigenome. These mutations have the potential to disrupt DNA methylation patterns, histone modifications and nucleosome positioning and hence, gene expression. Genetic alteration of the epigenome therefore contributes to cancer just as epigenetic process can cause point mutations and disable DNA repair functions. This crosstalk between the genome and the epigenome offers new possibilities for therapy.
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Cites
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Cited by
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.036 · Cited by 2,961
Epigenetic plasticity and the hallmarks of cancer
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“A major, unanticipated outcome of large-scale cancer genome sequencing projects is the finding that roughly 50% of human cancers harbor mutations in chromatin proteins (7, 8).”
BackgroundEpigenetic Determinants of Cancer
Baylin, S. B., & Jones, P. A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019505 · Cited by 1,226
Self-citationCancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance
Easwaran, H., Tsai, H.-C., & Baylin, S. B. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.015 · Cited by 915
DNA methylation dynamics in health and disease
Bergman, Y., & Cedar, H. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2518 · Cited by 592
Metadata
- Authors
- You, J. S., & Jones, P. A.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 22
- Issue
- 1
- Pages
- 9-20
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1980937575
- Cited by
- 1,167
- References
- 19
- FWCI
- 35.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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