LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
Shackelford, David B., Abt, Evan, Gerken, Laurie, Vasquez, Debbie S., Seki, Atsuko, Leblanc, Mathias, Wei, Liu, Fishbein, Michael C. +3 more·2013·Cancer Cell
Cited by (586)
Items 101–200 of 586
- Targeting KRAS Mutant Non-Small-Cell Lung Cancer: Past, Present and FutureIris Z. Uras, Herwig Peter Moll, Emilio Casanova · 2020 · International Journal of Molecular Sciences
- Cross-talk between protein synthesis, energy metabolism and autophagy in cancerLisa Lindqvist, Kristofferson V. Tandoc, Ivan Topisirović, Luc Furic · 2017 · Current Opinion in Genetics & Development
- Caloric restriction and cancer: molecular mechanisms and clinical implicationsOphélie Meynet, Jean‐Ehrland Ricci · 2014 · Trends in Molecular Medicine
- Phosphorylation of BRAF by AMPK Impairs BRAF-KSR1 Association and Cell ProliferationChe‐Hung Shen, Ping Yuan, Rolando Pérez‐Lorenzo, Yaqing Zhang, Sze Xian Lee, Yang Ou, John M. Asara, Lewis C. Cantley, Bin Zheng · 2013 · Molecular Cell
- Variant classification in precision oncologyJonas Leichsenring, Peter Horak, Simon Kreutzfeldt, Christoph Heining, Petros Christopoulos, Anna‐Lena Volckmar, Olaf Neumann, Martina Kirchner, Carolin Ploeger, Jan Budczies et al. · 2019 · International Journal of Cancer
- Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumorsMatilda Lee, Jayshree L. Hirpara, Jie Qing Eu, Gautam Sethi, Lingzhi Wang, Boon-Cher Goh, Andrea L.A. Wong · 2018 · Redox Biology
- An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic PotentialJonathan M. Goodwin, Robert U. Svensson, Hua Jane Lou, Monte M. Winslow, Benjamin E. Turk, Reuben J. Shaw · 2014 · Molecular Cell
- KRAS G12C in advanced NSCLC: Prevalence, co-mutations, and testingTony Kiat Hon Lim, Ferdinandos Skoulidis, Keith M. Kerr, Myung‐Ju Ahn, Joshua R. Kapp, Fernando Augusto Soares, Yasushi Yatabe · 2023 · Lung Cancer
- Evolving Lessons on the Complex Role of AMPK in Normal Physiology and CancerBiplab Dasgupta, Rishi Raj Chhipa · 2015 · Trends in Pharmacological Sciences
- Mitochondrial Complex I Activity Is Required for Maximal AutophagyHala Elnakat Thomas, Yu Zhang, Jonathan A. Stefely, Sónia R. Veiga, George Thomas, Sara C. Kozma, Carol A. Mercer · 2018 · Cell Reports
- Phenformin as an Anticancer Agent: Challenges and ProspectsMaría Eugenia García Rubiño, Esmeralda Carrillo, Gloria Ruiz-Alcalá, Alicia Domínguez‐Martín, Juan Antonio Marchal, Houría Boulaiz · 2019 · International Journal of Molecular Sciences
- Role of Mitochondria in Cancer Immune Evasion and Potential Therapeutic ApproachesKatherine Klein, Kewen He, Ahmed I. A. Younes, Hampartsoum B. Barsoumian, Dawei Chen, Tugce Ozgen, Sara Mosaffa, Roshal R. Patel, Meidi Gu, Jose A. Monteiro de Oliveira Novaes et al. · 2020 · Frontiers in Immunology
- Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatmentMichaël Pollak · 2014 · Nature Medicine
- Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1 -deficient Kras -driven lung tumorigenesisVrushank Dharmesh Bhatt, Khoosheh Khayati, Zhixian Sherrie Hu, Amy Shiu Lee, Wali Kamran, Xiaoyang Su, Jessie Yanxiang Guo · 2019 · Genes & Development
- AMP-activated protein kinase: A target for old drugs against diabetes and cancerGian Luigi Russo, Maria Russo, Paola Ungaro · 2013 · Biochemical Pharmacology
- The double-edged sword of AMPK signaling in cancer and its therapeutic implicationsSang‐Min Jeon, Nissim Hay · 2015 · Archives of Pharmacal Research
- Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid LeukemiaPierre Sujobert, Laury Poulain, Étienne Paubelle, Florence Zylbersztejn, Adrien Grenier, M. Lambert, Elizabeth C. Townsend, Jean-Marie G. Brusq, Edwige Nicodème, Justine Decrooqc et al. · 2015 · Cell Reports
- A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid LeukemiaTimothy S. Pardee, Rebecca G. Anderson, Kristin M. Pladna, Scott P. Isom, Lais P. Ghiraldeli, Lance David Miller, Jeff W. Chou, Guangxu Jin, Wei Zhang, Leslie Renee Ellis et al. · 2018 · Clinical Cancer Research
- Role of CPS1 in Cell Growth, Metabolism, and Prognosis in LKB1-Inactivated Lung AdenocarcinomaMüge Çeliktaş, Ichidai Tanaka, S. C. Tripathi, Johannes Francois Fahrmann, Clemente Aguilar-Bonavides, Pamela Andrea Villalobos, Oliver Delgado, Dilsher S. Dhillon, Jennifer B. Dennison, Edwin Justin Ostrin et al. · 2016 · JNCI Journal of the National Cancer Institute
- Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy StressSzu-Wei Lee, Chien‐Feng Li, Guoxiang Jin, Zhen Cai, Fei Han, Chia‐Hsin Chan, Wei‐Lei Yang, Binkui Li, Abdol Hossein Rezaeian, Hongyu Li et al. · 2015 · Molecular Cell
- Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapyAlba Luengo, Lucas B. Sullivan, Matthew G. Vander Heiden · 2014 · BMC Biology
- STK11/LKB1 Modulation of the Immune Response in Lung Cancer: From Biology to Therapeutic ImpactElvire Pons Tostivint, Alexandre Lugat, Jean-François Fontenau, Marc Guillaume Denis, Jaafar Bennouna · 2021 · Cells
- Antidiabetic Drugs: Mechanisms of Action and Potential Outcomes on Cellular MetabolismMaria João Meneses, Branca Maria Silva, Mário Sousa, Rosália Sá, Pedro Fontes Oliveira, Marco Gouveia Alves · 2015 · Current Pharmaceutical Design
- Metformin Enhances Cisplatin-Induced Apoptosis and Prevents Resistance to Cisplatin in Co-mutated KRAS/LKB1 NSCLCMassimo Moro, Elisa Caiola, Monica Ganzinelli, Elisabetta Zulato, Eliana Rulli, Mirko Marabese, Giovanni Centonze, Adele Busico, Ugo Pastorino, Filippo de Braud et al. · 2018 · Journal of Thoracic Oncology
- Body Mass Index and Its Association with Clinical Outcomes for Advanced Non–Small-Cell Lung Cancer Patients Enrolled on Eastern Cooperative Oncology Group Clinical TrialsSuzanne Eleanor Dahlberg, Joan H. Schiller, Philip Bonomi, Alan B. Sandler, Julie Renee Brahmer, Suresh S. Ramalingam, David H. Johnson · 2013 · Journal of Thoracic Oncology
- AMPK and CancerZhiyu Wang, Neng Wang, Pengxi Liu, Xiaoming Xie · 2016 · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions
- Metformin: A Novel Biological Modifier of Tumor Response to Radiation TherapyMarianne Koritzinsky · 2015 · International Journal of Radiation Oncology*Biology*Physics
- Hierarchical targeted hepatocyte mitochondrial multifunctional chitosan nanoparticles for anticancer drug deliveryZhipeng Chen, Liujie Zhang, Yang Song, Jiayu He, Li Wu, Can Zhao, Yanyu Xiao, Wei Li, Baochang Cai, Haibo Cheng et al. · 2015 · Biomaterials
- Molecular Pathways: BRAF Induces Bioenergetic Adaptation by Attenuating Oxidative PhosphorylationRizwan Haq, David E. Fisher, Hans R. Widlund · 2014 · Clinical Cancer Research
- Non-Small-Cell Lung Cancer Signaling Pathways, Metabolism, and PD-1/PD-L1 AntibodiesMariacarmela Santarpía, Andrés Aguilar, Imane CHAIB-OUKADOUR, Andrés Felipe Cardona, Sara Fancelli, Fernando Laguía, Jillian Wilhelmina Paulina Bracht, Peng Cao, Miguel Ángel Molina‐Vila, Niki Karachaliou et al. · 2020 · Cancers
- The Anti-Proliferative Effect of Metformin in Triple-Negative MDA-MB-231 Breast Cancer Cells Is Highly Dependent on Glucose Concentration: Implications for Cancer Therapy and PreventionZordoky, Beshay N.M., Bark, Diana, Soltys, Carrie L., Sung, Miranda M., Dyck, Jason R.B. · 2014 · Biochimica et Biophysica Acta (BBA) - General Subjects
- Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastomaWei Jiang, Susan Finniss, Simona Cazacu, Cunli Xiang, Ziv Brodie, Tom Mikkelsen, Laila Poisson, David B. Shackelford, Chaya Brodie · 2016 · Oncotarget
- Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non–Small Cell Lung CancerRui Li, Ramin Salehi‐Rad, William P. Crosson, Milica Momcilovic, Raymond J. Lim, Stephanie L. Ong, Zi Ling Huang, Tian-hao Zhang, Jensen W. Abascal, Camelia Dumitras et al. · 2021 · Cancer Research
- Targeting LKB1 in Cancer – Exposing and Exploiting VulnerabilitiesMomcilovic, M, Shackelford, D B · 2015 · British Journal of Cancer
- Regulation of bioenergetics through dual inhibition of aldehyde dehydrogenase and mitochondrial complex I suppresses glioblastoma tumorspheresJunseong Park, Jin‐Kyoung Shim, Joon Hee Kang, Junjeong Choi, Jong Hee Chang, Soo‐Youl Kim, Seok‐Gu Kang · 2017 · Neuro-Oncology
- Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicityIan P. Winters, Shin‐Heng Chiou, Nicole K. Paulk, Christopher D. McFarland, Pranav V. Lalgudi, Rosanna K. Ma, Leszek Lisowski, Andrew J. Connolly, Dmitri A. Petrov, Mark A. Kay et al. · 2017 · Nature Communications
- YAP Promotes Malignant Progression of Lkb1 -Deficient Lung Adenocarcinoma through Downstream Regulation of SurvivinWenjing Zhang, Yijun Gao, Fuming Li, Xinyuan Tong, Yan Ren, Xiangkun Han, Shun Yao, Fei Long, Zhongzhou Yang, Heng‐Yu Fan et al. · 2015 · Cancer Research
- Metformin: A Novel but Controversial Drug in Cancer Prevention and TreatmentXinbing Sui, Yinghua Xu, Xian Wang, Weidong Han, Hongming Pan, Mang Xiao · 2015 · Molecular Pharmaceutics
- LKB1 Loss Induces Characteristic Patterns of Gene Expression in Human Tumors Associated with NRF2 Activation and Attenuation of PI3K-AKTKaufman, Jacob M., Amann, Joseph M., Park, Kyungho, Arasada, Rajeswara Rao, Li, Haotian, Shyr, Yu, Carbone, David P. · 2014 · Journal of Thoracic Oncology
- Metformin: current clinical applications in nondiabetic patients with cancerKailin Chen, Yajun Li, Zhen Guo, Yong Zeng, Wei Zhang, Hui Wang · 2020 · Aging
- LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseasesYanghe Zhang, Qingfei Meng, Qianhui Sun, Zhixiang Xu, Honglan Zhou, Yishu Wang · 2020 · Molecular Metabolism
- Dissecting the role of AMP-activated protein kinase in human diseasesJin Li, Liping Zhong, Fengzhong Wang, Haibo Zhu · 2017 · Acta Pharmaceutica Sinica B
- Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic InflammationShenghong Yang, Yu Imamura, Russell William Jenkins, Israel Cañadas, Shunsuke Kitajima, Amir Reza Aref, Arthur Brannon, Eiji Oki, Adam B. Castoreno, Zehua Zhu et al. · 2016 · Cancer Immunology Research
- Evidence of cancer‐promoting roles for AMPK and related kinasesTiziana Monteverde, Nathiya Muthalagu, Jennifer Port, Daniel J. Murphy · 2015 · FEBS Journal
- A reappraisal on metforminTuğba Adak, Afshin Samadi, Ayşe Zeynep Ünal, Suna Sabuncuoğlu · 2017 · Regulatory Toxicology and Pharmacology
- Different prognostic impact ofSTK11mutations in non-squamous non-small-cell lung cancerNicolas Pécuchet, Pierre Laurent‐Puig, Audrey Mansuet‐Lupo, Antoine Legras, Marco Alifano, Karine Pallier, Audrey Didelot, Laure Gibault, Claire J. Danel, Pierre‐Alexandre Just et al. · 2015 · Oncotarget
- Metabolic reprogramming of carcinoma-associated fibroblasts and its impact on metabolic heterogeneity of tumorsDuojiao Wu, Leying Zhuo, Xiangdong Wang · 2016 · Seminars in Cell and Developmental Biology
- Inflammation as a driver and vulnerability of KRAS mediated oncogenesisShunsuke Kitajima, Rohit Thummalapalli, David Allen Barbie · 2016 · Seminars in Cell and Developmental Biology
- Oncogene-Driven Metabolic Alterations in CancerHye‐Young Min, Ho‐Young Lee · 2017 · Biomolecules & Therapeutics
- Syrosingopine sensitizes cancer cells to killing by metforminDon Benjamin, Marco Colombi, Sravanth Kumar Hindupur, Charles Betz, Heidi A. Lane, Mahmoud El‐Shemerly, Min Lu, Luca Quagliata, Luigi Terracciano, Suzette Moes et al. · 2016 · Science Advances
- Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancersBetty Yuen Kwan Law, Simon Wing Fai Mok, Wai Kit Chan, Su Xu, Anguo Wu, Xiao Yao, Jing Rong Wang, Liang Liu, Vincent Kam Wai Wong · 2016 · Oncotarget
- lncRNA NEAT1 competes against let-7a to contribute to non-small cell lung cancer proliferation and metastasisQi Li, Fang Liu, Feng Zhang, Shuai Zhang, Liyan Lv, Yi Bi, Yan Yu · 2018 · Biomedicine & Pharmacotherapy
- CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased LipogenesisLucy Penfold, Angela Woods, Phillip J. Muckett, Alexander Yu. Nikitin, Tera R. Kent, Shuai Zhang, Rebecca Graham, Alice Pollard, David Carling · 2018 · Cancer Research
- Pyruvate kinase M knockdown–induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survivalGopinath Prakasam, Rajnish Kumar Singh, Mohammad Askandar Iqbal, Sunil Kumar Saini, Ashu Bhan Tiku, Ramesh N K Bamezai · 2017 · Journal of Biological Chemistry
- Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinaseHannah R. Bridges, Ville A. Sirviö, Ahmed-Noor Adam Agip, Judy Hirst · 2016 · BMC Biology
- Effects of metformin and phenformin on apoptosis and epithelial‐mesenchymal transition in chemoresistant rectal cancerJi‐Hye Park, Young‐Heon Kim, Eun Hyeh Park, Sun‐Joo Lee, Hye Won Kim, Areumnuri Kim, Seung Bum Lee, Sehwan Shim, Hyosun Jang, Jae Kyung Myung et al. · 2019 · Cancer Science
- The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killingValentina Tesori, Anna Chiara Piscaglia, Daniela Samengo, Marta Barba, Camilla Bernardini, Roberto Scatena, Alessandro Pontoglio, Laura Castellini, Johannes N. Spelbrink, Giuseppe Maulucci et al. · 2015 · Scientific Reports
- Sorafenib synergizes with metformin in NSCLC through AMPK pathway activationFloris H. Groenendijk, Wouter Willem Mellema, Eline van der Burg, Eva Schut, Michael Hauptmann, Hugo M. Horlings, Stefan M. Willems, Michel M. van den Heuvel, Jos Jonkers, Egbert Frederik Smit et al. · 2014 · International Journal of Cancer
- HDAC3 is critical in tumor development and therapeutic resistance in Kras -mutant non–small cell lung cancerLillian J. Eichner, Stephanie D. Curtis, Sonja N. Brun, Caroline K. McGuire, Irena Gushterova, Joshua T. Baumgart, Elijah Trefts, Debbie S. Ross, Tammy J. Rymoff, Reuben J. Shaw · 2023 · Science Advances
- lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1Xiaowen Liu, Boyi Gan · 2016 · Cell Cycle
- Controlling the master—upstream regulation of the tumor suppressor LKB1Kullmann, Lars, Krahn, Michael P. · 2018 · Oncogene
- Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancerRay Pillai, Sarah E. LeBoeuf, Yuan Hao, Connie New, Jenna L. E. Blum, Ali Rashidfarrokhi, Shih Ming Huang, Christian Bahamon, Warren Wu, Burcu Karadal-Ferrena et al. · 2024 · Science Advances
- A story of metformin-butyrate synergism to control various pathological conditions as a consequence of gut microbiome modification: Genesis of a wonder drug?Kunal Maniar, Amal Moideen, Ankur Mittal, Amol Patil, Amitava Chakrabarti, Dibyajyoti Banerjee · 2016 · Pharmacological Research
- The LKB1-AMPK Pathway—Friend or Foe in Cancer?David Grahame Hardie · 2013 · Cancer Cell
- Metabolic rewiring in mutant Kras lung cancerEmma M. Kerr, Carla P. Martins · 2017 · FEBS Journal
- Dihydroartemisinin Inhibits Glucose Uptake and Cooperates with Glycolysis Inhibitor to Induce Apoptosis in Non-Small Cell Lung Carcinoma CellsYanjun Mi, Guojun Geng, Zhengzhi Zou, Jing Gao, Xianyang Luo, Yu Liu, Ning Li, Chunlei Li, Yuqiang Chen, Xiuyi Yu et al. · 2015 · PLoS ONE
- Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancerAlba Luengo, Keene L. Abbott, Shawn M. Davidson, Aaron M. Hosios, Brandon Faubert, Sze Ham Chan, Elizaveta Freinkman, Lauren G. Zacharias, Thomas P. Mathews, Clary B. Clish et al. · 2019 · Nature Communications
- Recent Progress on Liver Kinase B1 (LKB1): Expression, Regulation, Downstream Signaling and Cancer Suppressive FunctionRen‐You Gan, Hua‐Bin Li · 2014 · International Journal of Molecular Sciences
- Snail acetylation by autophagy‐derived acetyl‐coenzyme A promotes invasion and metastasis of KRAS ‐ LKB1 co‐mutated lung cancer cellsJang Hee Han, Yong Keon Kim, Hakhyun Kim, Jooyoung Lee, Myung Joon Oh, Minjee Kim, Kook Hwan Kim, Kook Hwan Kim, Hyun Ju Yoon, Myung‐Shik Lee et al. · 2022 · 癌症:英文版
- LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolismQinghua Zeng, J Chen, Yong Li, Kaitlin D. Werle, R-X Zhao, C-S Quan, Y-S Wang, Y-X Zhai, Wang Jw, Mariam Youssef et al. · 2016 · Oncogene
- A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and OrgansYumi Konagaya, Kenta Terai, Yusuke Hirao, Kanako Takakura, Masamichi Imajo, Yuji Kamioka, Norio Sasaoka, Akira Kakizuka, Kenta Sumiyama, Tomoichiro Asano et al. · 2017 · Cell Reports
- Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK ActivationDiana Vara‐Ciruelos, Madhumita Dandapani, Fiona M. Russell, Katarzyna M. Grzes, Abdelmadjid Atrih, Marc Foretz, Benoı̂t Viollet, Douglas J. Lamont, Doreen Ann Cantrell, David Grahame Hardie · 2019 · Cell Reports
- The Mechanism of Action of Biguanides: New Answers to a Complex QuestionLaura Di Magno, Fiorella Di Pastena, Rosa Bordone, Sonia Coni, Gianluca Canettieri · 2022 · Cancers
- FBXO22 mediates polyubiquitination and inactivation of LKB1 to promote lung cancer cell growthXiaona Zhu, Ping He, Liang Zhang, Shuo Yang, Huilin Zhang, Di Zhu, Meng-Di Liu, Yun Yu · 2019 · Cell Death and Disease
- Clinical, molecular, and radiomic profile of gliomas with FGFR3-TACC3 fusionsAnna Luisa Di Stefano, Alberto Pïcca, Édouard Saragoussi, Franck Bielle, François Ducray, Chiara Villa, Marica Eoli, Rosina Paterra, Luisa Bellu, Bertrand Mathon et al. · 2020 · Neuro-Oncology
- Therapeutic Repurposing of Biguanides in CancerHongyun Zhao, Kenneth D. Swanson, Bin Zheng · 2021 · Trends in cancer
- Mitochondrial mutations and metabolic adaptation in pancreatic cancerAustralian Pancreatic Cancer Genome Initiative, Rae‐Anne Hardie, Ellen van Dam, Mark J. Cowley, Ting-Li Han, Seher Balaban, Marina Pajic, Mark Pinese, Mary Iconomou, Robert F. Shearer et al. · 2017 · Cancer & Metabolism
- Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 statusSara Granja, Ibtissam Marchiq, Renaud LeFloch, Conceição Souto Moura, Fátima Baltazar, Jacques Pouysségur · 2014 · Oncotarget
- Sensitization of metformin-cytotoxicity by dichloroacetate via reprogramming glucose metabolism in cancer cellsYong Won Choi, In Kyoung Lim · 2014 · Cancer Letters
- Small Molecule KRAS Agonist for Mutant KRAS Cancer TherapyKe Xu, Dongkyoo Park, Andrew T. Magis, Jun Zhang, Wei Zhou, Gabriel Sica, Suresh S. Ramalingam, Walter John Curran, Xingming Deng · 2019 · Molecular Cancer
- Aspirin inhibits the proliferation of hepatoma cells through controlling GLUT1-mediated glucose metabolismYunxia Liu, Jinyan Feng, Mingming Sun, Bowen Liu, Guang Yang, Yanan Bu, Man Zhao, Tianjiao Wang, Weiying Zhang, Hong-Feng Yuan et al. · 2018 · Acta Pharmacologica Sinica
- MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarityMaría José Sandí, Christopher B. Marshall, Marc Balan, Étienne Coyaud, Ming Zhou, Daniel M. Monson, Noboru Ishiyama, Arun A. Chandrakumar, José La Rose, Amber L. Couzens et al. · 2017 · Science Signaling
- Targeting cellular metabolism to reduce head and neck cancer growthJian Yang, Yuqi Guo, Wonkyu Seo, Ruohan Zhang, Cuijie Lu, Yaoyu E. Wang, Liang Luo, Bidisha Paul, Wenbo Yan, Deepak B. Saxena et al. · 2019 · Scientific Reports
- KRAS/LKB1 and KRAS/TP53 co-mutations create divergent immune signatures in lung adenocarcinomasMeichen Gu, Tiankai Xu, Pengyu Chang · 2021 · Therapeutic Advances in Medical Oncology
- LKB1 reduces ROS-mediated cell damage via activation of p38H-G Xu, Y-X Zhai, Jianfeng Chen, Yan Lu, J-W Wang, C-S Quan, R-X Zhao, Xiao Xiao, Qiongqiong He, Kaitlin D. Werle et al. · 2014 · Oncogene
- Targeting the LKB1 Tumor SuppressorRui–Xun Zhao, Zhi‐Xiang Xu · 2014 · Current Drug Targets
- LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cellsYoung Mi Whang, Serk In Park, Irina A. Trenary, Robert A. Egnatchik, Joshua P. Fessel, Jennifer Kaufman, David Paul Carbone, Jamey D. Young · 2015 · Oncogene
- Mechanisms of metformin inhibiting cancer invasion and migration.Yong Chang Chen, He Li, Jing Wang · 2020 · PubMed Central
- The Metabolic Heterogeneity and Flexibility of Cancer Stem CellsAtsushi Tanabe, Hiroeki Sahara · 2020 · Cancers
- Energy metabolism in cancer stem cellsXuan Zhu, Huihui Chen, Chenyi Gao, Xinxin Zhang, Jingxin Jiang, Yi Zhang, Jun Fang, Feng Zhao, Zhigang Chen · 2020 · World Journal of Stem Cells
- AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?Fiona M. Russell, David Grahame Hardie · 2020 · International Journal of Molecular Sciences
- Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinomaMelissa Gilbert‐Ross, Jessica Marie Konen, Junghui Koo, John A. Shupe, Brian Scott Robinson, Walter Guy Wiles, Chunzi Huang, W. David Martin, Madhusmita Behera, Geoffrey Hughes Smith et al. · 2017 · JCI Insight
- Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon CancerYongliang Wang, Ali R. Nasiri, William Damsky, Curtis J. Perry, Xian‐Man Zhang, Aviva Rabin-Court, Michaël Pollak, Gerald I. Shulman, Rachel J. Perry · 2018 · Cell Reports
- Metformin as a repurposed therapy in advanced non-small cell lung cancer (NSCLC): results of a phase II trialAnish B. Parikh, Peter S. Kozuch, Nicholas Cole Rohs, Daniel Jacob Becker, Benjamin Philip Levy · 2017 · Investigational New Drugs
- A nanoparticle vaccine that targets neoantigen peptides to lymphoid tissues elicits robust antitumor T cell responsesCarlos A. Arbelaez, Juan Estrada, Melissa A. Gessner, Charles Glaus, Agnieszka B. Morales, Deanna Mohn, Hyewon Phee, James Russell Lipford, James A. Johnston · 2020 · npj Vaccines
- Metformin, an Old Drug, Brings a New Era to Cancer TherapyHuan He, Rong Ke, Hui Lin, Ying Ying, Dan Liu, Zhijun Luo · 2015 · The Cancer Journal
- Multispectral ImagingJames Robert Mansfield · 2013 · Veterinary Pathology
- LKB1 promotes metabolic flexibility in response to energy stressSeth J. Parker, Robert U. Svensson, Ajit S. Divakaruni, Austin E.Y.T. Lefebvre, Anne N. Murphy, Reuben J. Shaw, Christian M. Metallo · 2016 · Metabolic Engineering
- Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapyMelin Janardan Khandekar, Alexander S. Banks, Dina Laznik-Bogoslavski, James P. White, Jang Hyun Choi, Lawrence Kazak, James C. Lo, Paul Cohen, Kwok‐Kin Wong, Theodore M. Kamenecka et al. · 2018 · Proceedings of the National Academy of Sciences
- Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killingYong Wu, Marianna Sarkissyan, Eva M. McGhee, Sangkyu Lee, Jaydutt V. Vadgama · 2015 · Breast Cancer Research and Treatment