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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Somatic mutations affect key pathways in lung adenocarcinoma

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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Metformin and reduced risk of cancer in diabetic patients

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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Metabolic Phenotypes, Dependencies, and Adaptation in Lung CancerPreprint

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Metabolic barriers in non-small cell lung cancer with LKB1 and/or KEAP1 mutations for immunotherapeutic strategies

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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

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Beyond LKB1 Mutations in Non-Small Cell Lung Cancer: Defining LKB1less Phenotype to Optimize Patient Selection and Treatment

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A phase II study of metformin plus pemetrexed and carboplatin in patients with non-squamous non-small cell lung cancer (METALUNG)

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LKB1 deficiency promotes proliferation and invasion of glioblastoma through activation of mTOR and focal adhesion kinase signaling pathways.

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Combinatorial Therapeutic Effect of Inhibitors of Aldehyde Dehydrogenase and Mitochondrial Complex I, and the Chemotherapeutic Drug, Temozolomide against Glioblastoma Tumorspheres

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Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado

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Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC

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AMP-activated protein kinase mediates adaptation of glioblastoma cells to conditions of the tumor microenvironment

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14-3-3zeta is involved in the anticancer effect of metformin in colorectal carcinoma

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Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma

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A new mechanism for LKB1 activation

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Kinase signalling adaptation supports dysfunctional mitochondria in disease

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Screening of patient-derived organoids identifies mitophagy as a cell-intrinsic vulnerability in colorectal cancer during statin treatment

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Precision immune regulation in KRAS-mutated cancers: the final piece of the puzzle?

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Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179

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Nutrient sensing lost in cancer

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Phosphorylation of CREB-Specific Coactivator CRTC2 at Ser238 Promotes Proliferation, Migration, and Invasion of Colorectal Cancer Cells

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Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer?

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Epithelial–Mesenchymal Transition Suppresses AMPK and Sensitizes Cancer Cells to Pyroptosis under Energy Stress

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Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells

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A critical appraisal of the role of metabolomics in breast cancer research and diagnostics

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Activators of AMPK: Not Just for Type II Diabetes

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LKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions

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Metabolic reprograming of antioxidant defense: a precision medicine perspective for radiotherapy of lung cancer?

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Identification of a novel mitochondria-localized LKB1 variant required for the regulation of the oxidative stress response

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Effect of metformin use on the risk and prognosis of ovarian cancer: an updated systematic review and meta-analysis

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LKB1 mutations are not associated with the efficacy of first-line and second-line chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC): a post hoc analysis of the TAILOR trial

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Bioenergetic modulators hamper cancer cell viability and enhance response to chemotherapy

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Comparison of the effects of metformin on MDA-MB-231 breast cancer cells in a monolayer culture and in tumor spheroids as a function of nutrient concentrations

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Energy metabolism modulation by biguanides in comparison with rotenone in rat liver and heart

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The role of mTOR signaling pathway on cognitive functions in cerebral ischemia-reperfusion

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Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness

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A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer

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The role and therapeutic potential of glucose metabolism in multidrug resistance of cancer

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Contact Normalization or Escape from the Matrix

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Novel putative drivers revealed by targeted exome sequencing of advanced solid tumors

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Molecular Targets Beyond the Big 3

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Phenformin and ataxia‐telangiectasia mutated inhibitors synergistically co‐suppress liver cancer cell growth by damaging mitochondria

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Non-small cell lung cancer molecular characterization of advanced disease with focus on sex differences: a narrative review

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Redox-dependent AMPK inactivation disrupts metabolic adaptation to glucose starvation in xCT-overexpressing cancer cells

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Metabolic targeting of malignant tumors: a need for systemic approach

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Metabolic targeting, immunotherapy and radiation in locally advanced non-small cell lung cancer: Where do we go from here?

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The Impact of Genomic Profiling for Novel Cancer Therapy – Recent Progress in Non-Small Cell Lung Cancer

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Calcium-Dependent Enhancement by Extracellular Acidity of the Cytotoxicity of Mitochondrial Inhibitors against Melanoma

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Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients

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Synthetic Lethality in Lung Cancer—From the Perspective of Cancer Genomics

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HDAC3 regulates senescence and lineage specificity in non-small cell lung cancerPreprint

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Metformin-Induced Apoptosis Is Mediated Through Mitochondrial VDAC1

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Progress in antitumor mechanisms and applications of phenformin (Review)

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Serum levels of lipocalin-2 are elevated at early times in African American relapsing remitting multiple sclerosis patients.

Kalinin, S., Boullerne, A., & Feinstein, D. (2022) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2022.577810 · Cited by 5

Synergistic Effects of Metformin and Trastuzumab on HER2 Positive Gastroesophageal Adenocarcinoma Cells In Vitro and In Vivo

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Influence of body mass index on the therapeutic efficacy of gemcitabine plus cisplatin and overall survival in lung squamous cell carcinoma

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NBR2-GLUT1 axis regulates cancer cell sensitivity to biguanides

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Metformin promotes anti-tumor immunity in STK11 mutant NSCLC through AXIN1-dependent upregulation of multiple nucleotide metabolites

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Metformin resistant MDA-MB-468 cells exhibit EMT-like phenotype and increased migration capacity

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LKB1 cooperates with Sox17 to drive metastasis

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Клинический случай легочной формы мукормикоза у ребенка с острым лимфобластным лейкозом

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Oncogenic mutation profiling in new lung cancer and mesothelioma cell lines

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Advances in Research on the Anticancer Properties and Mechanisms of Metformin in Lung Cancer

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C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer

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AI-derived body composition analysis reveals muscle volume and metformin-associated adipose effects and the obesity paradox in non-small cell lung cancer

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Anti-diabetic Drugs and Cancer: Integrated Mechanisms of Tumor Suppression and Clinical Translation

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Metabolism, autophagy, and cell death: The triangular axis in tumor survival and therapeutic resistance

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Lymph node metastasis in early invasive lung adenocarcinoma: Prediction model establishment and validation based on genomic profiling and clinicopathologic characteristics

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Oxidative phosphorylation related gene COA6 is a novel indicator for the prognosis and immune response in lung adenocarcinoma

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The Renaissance of KRAS Targeting in Advanced Non-Small-Cell Lung Cancer: New Opportunities Following Old Failures

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Promising novel biomarkers and candidate small-molecule drugs for lung adenocarcinoma: Evidence from bioinformatics analysis of high-throughput data

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Role ofSTK11inALK‑positive non‑small cell lung cancer (Review)

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Cancer metabolism in breadth and depth

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LKB1 inactivation occurs in a subset of esophageal adenocarcinomas and is sufficient to drive tumor cell proliferation

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Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significancePreprint

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AMP-kinase mediates adaptation of glioblastoma cells to conditions of the tumour microenvironmentPreprint

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Pulmonary Solid and Granular Adenocarcinomas Expressing HepPar1/CPS1: Highly Aggressive Tumors Exhibiting Mitochondrial Adaptation to STK11 Mutations Rather Than Hepatoid Differentiation

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Chemoprevention of 4-NQO-Induced Oral Cancer by the Combination of Resveratrol and EGCG: In Vivo, In Silico and In Vitro Studies

Adeluola, A. A., Raji, L. M., Sigdel, S., Anisuzzaman, A. S. M., Hossain, M. S., & Amin, A. R. M. R. (2026) · Cancers · doi:10.3390/cancers18071098 · Cited by 3

Targeting Energy Metabolism to Overcome Therapeutic Resistance of Glioblastoma and Tumor-associated Edema

Dasgupta, B., Hirota, Y., Fujii, Y., Osaka, N., Ito, D., Plas, D. R., & Sasaki, A. T. (2021) · Exon Publications eBooks · doi:10.36255/exonpublications.gliomas.2021.chapter7 · Cited by 3

Current status and trend of mitochondrial research in lung cancer: A bibliometric and visualization analysis

Kong, Q., Zhu, Q., Yang, Y., Wang, W. J., Qian, J., & Chen, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34442 · Cited by 3

Mitochondria in Lung Cancer Progression

Noguchi, M., Iwata, K., Shintani, N., & Kasahara, A. (2024) · Current Pharmacology Reports · doi:10.1007/s40495-024-00361-3 · Cited by 4

Autophagy in cholangiocarcinoma: a comprehensive review about roles and regulatory mechanisms

Yang, Y., Li, Q., Chu, L. T., Lin, X., Chen, H., Chen, L., Tang, J. Y., & Zeng, T. (2024) · Clinical & Translational Oncology · doi:10.1007/s12094-024-03797-7 · Cited by 3

New Targets for Therapy in Lung Cancer

Mansfield, A. S., Dy, G. K., Ahn, M.-J., & Adjei, A. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-52357-8.00048-2 · Cited by 2

Metabolic classification of non-small cell lung cancer patient-derived xenografts by a digital pathology approach: A pilot study

Ferrarini, F., Zulato, E., Moro, M., Bianco, P. D., Borzi, C., Esposito, G., Zanin, T., Sozzi, G., & Indraccolo, S. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1070505 · Cited by 3

Genetic and Epigenetic Host–Virus Network to Investigate Pathogenesis and Identify Biomarkers for Drug Repurposing of Human Respiratory Syncytial Virus via Real-World Two-Side RNA-Seq Data: Systems Biology and Deep-Learning Approach

Hsu, B., & Chen, B. (2023) · Biomedicines · doi:10.3390/biomedicines11061531 · Cited by 3

Downregulation of GFPT2 enhances cisplatin chemotherapy sensitivity in STK11/KRAS mutant non-small cell lung cancer by regulating the hexosamine biosynthesis pathway, resisting tumor growth

Zhang, C., Yin, X., Jiang, J. H., Wang, P., & Wang, Y. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156943 · Cited by 3

Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers

Huffman, K. E., Li, L. S., Carstens, R. M., Park, H., Girard, L., Avila, K., Wei, S., Kollipara, R. K., Timmons, B. C., Sudderth, J., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1025443 · Cited by 4

Potential and real ‘antineoplastic’ and metabolic effect of metformin in diabetic and nondiabetic postmenopausal females

Berstein, L. M., Vasilyev, D. A., Iyevleva, A. G., Boyarkina, M. P., Евгеньевна, П. Т., Khadzhimba, A. S., & Имянитов, Е. Н. (2015) · Future Oncology · doi:10.2217/fon.14.317 · Cited by 3

HL271, a novel chemical compound derived from metformin, differs from metformin in its effects on the circadian clock and metabolism

Row, H., Jeong, J., Cho, S., Kim, S., & Kim, K. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.11.069 · Cited by 3

Mesothelioma Interactome with 367 Novel Protein-Protein InteractionsPreprint

Karunakaran, K. B., Yanamala, N. V. K., Boyce, G., & Ganapathiraju, M. K. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/459065 · Cited by 3

Synthetic lethality targeting LKB1 mutant and EGFR wild type human non-small cell lung cancer cells by glucose starvation and SGLT2 inhibitionPreprint

Ren, Y., Chen, J., Mo, X., Yang, Q., Chen, P., Lu, G. X., Tan, H. W. S., Yi, J., Yu, Q., Kim, Y., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/622126 · Cited by 3

The hexosamine biosynthesis pathway is a targetable liability in lung cancers with concurrent KRAS and LKB1 mutationsPreprint

Kim, J., Cai, F., Ko, B., Yang, C., Lee, H. M., Muhammad, N., Li, K., Haloul, M., Gu, W., Faubert, B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.13.039669 · Cited by 3

Inhibition of ULK1/2 and KRAS G12C controls tumor growth in preclinical models of lung cancerPreprint

Ghazi, P. C., O’Toole, K. T., Boggaram, S. S., Scherzer, M. T., Silvis, M. R., Zhang, Y., Jagannathan‐Bogdan, M., Smith, B. D., Lozano, G., Flynn, D. L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.06.579200 · Cited by 3

Sialin2 Functions as a Mammalian Nitrate Sensor to Sustain Mitochondrial HomeostasisPreprint

Li, X., Wu, S., Cao, Z., Jiang, O., Li, S., Chen, X., Feng, Y., Zhou, B., Zhang, C., Xiao, G., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.04.652104 · Cited by 5

Isoguanosine-Induced ER Stress via AMPK Enhances Chemosensitivity in OSCC

Yao, J. J., Song, S., Liu, T., Wang, J., Li, C., Liu, J., Yao Zong, Y. U. A. N., & Zhao, H. (2025) · Journal of Dental Research · doi:10.1177/00220345241303168 · Cited by 2

Phenforminium fenbufenate as the first dual-drug molecular salt of phenformin with NSAIDs towards tuning dissolution behavior and enhancing synergic anticancer activity in vitro

Song, Y., Wang, M.-Q., Yu, L.-N., Gao, Y., Bi, J., Wang, L., Bu, F.-Z., Wu, Z., & Li, Y. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.143252 · Cited by 2

Oxidative stress and cancer metabolism: From pathogenesis to therapeutic opportunities

Agnihotri, T. G., Gomte, S. S., Rout, B., Peddinti, V., Maharana, S. K., Yallappa, D., & Jain, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33459-7.00006-5 · Cited by 3

Modeling lipid homeostasis using stable isotope tracing and flux analysis

Wessendorf-Rodriguez, K. A., Ruchhoeft, M. L., Murray, C. W., Huang, Y., Ashley, E. L., Galvez, H. M., McGregor, G. H., Kambhampati, S., Shaw, R. J., & Metallo, C. M. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.01.020 · Cited by 4

AMPK signaling in cancer: dual roles, molecular mechanisms, and therapeutic potential

Dërmaku‐Sopjani, M., Morina, R., Sermaxhaj, F., Kurti, F., Latifi, J., & Sopjani, M. (2026) · Advances in Medical Sciences · doi:10.1016/j.advms.2026.05.001 · Cited by 3

Energizing the Search to Target LKB1-Mutant Tumors

Marcus, A. I., & Khuri, F. R. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0296 · Cited by 2

Metformine et cancer : passé, présent, avenir

Loubière, C., Dirat, B., Tanti, J., & Bost, F. (2014) · Obésité · doi:10.1007/s11690-014-0418-9 · Cited by 3

Abstract 2449: Identifying therapy responsive and resistant LKB1 mutant non-small cell lung tumor populations

Abt, E. R., Momcilovic, M., Seki, A., McMickle, R., Stout, D., Fishbein, M. C., & Shackelford, D. B. (2014) · Cancer Research · doi:10.1158/1538-7445.am2014-2449

LKB1 Mutation Sensitizes NSCLC Cells to Phenformin

(2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2013-023 · Cited by 1

Abstract C114: The role of LKB1 and TP53 mutation status in determining sensitivity of non-small cell lung cancer cells to the metabolic inhibitors; metformin, phenformin and 2-DG

Cahill, F. F., Bokobza, S., Devery, A., Drobnitzky, N., Jiang, Y., Lourenço, L. M., Mumin, N. H., Weber, A. M., Ashton, T. M., & Ryan, A. J. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-15-c114

MA17.02 Identify Vulnerable Pathways and Improve Treatment Outcomes in LKB1-Deficient Lung Tumors

Welliver, M. X., Jin, F., Amann, J. M., Koenig, M. J., Mo, X. M., & Carbone, D. P. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2019.08.638

Heightening Energetic Stress Selectively Targets LKB1-Deficient Non–Small Cell Lung Cancers

Momcilovic, M., McMickle, R., Abt, E., Seki, A., Simko, S. A., Magyar, C., Stout, D. B., Fishbein, M. C., Walser, T. C., Dubinett, S. M., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0797 · Cited by 46